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Biodegradable medical Zn-Li-X series alloy material and preparation method and application

An alloy material and biological technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of poor comprehensive mechanical properties of pure zinc, low strength of zinc alloy materials, slow corrosion rate, etc., to prevent schizophrenia, improve Strength and plasticity, the effect of optimizing the structure

Inactive Publication Date: 2017-01-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the comprehensive mechanical properties of pure zinc are poor, and the corrosion rate is also slow, so it is difficult to meet the needs of clinical medicine. Alloying pure zinc is the main method to improve its mechanical properties and corrosion rate. Fe, Li and trace elements Mg, Ca, Sr, Si, Mn and rare earth elements are added to zinc at the same time, but the strength of the zinc alloy material prepared by this application is low. We found that zinc-lithium alloy has higher strength and Plasticity, while adding at least one element of low microalloying elements Cu, Ag, Mn, Mg, Si, Ca, and Sr can further regulate the strength, plasticity and corrosion rate of zinc alloys, making up for the zinc-lithium binary alloys in regulation Insufficient in mechanical properties and corrosion rate, it has more advantages as a degradable medical material

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment relates to a degradable medical Zn-Li-X alloy material, which includes the following alloy components in weight percentage: Li is 0.1%, Cu is 4%, and the rest is Zn.

[0037] The preparation method of the alloy material comprises the following steps:

[0038] S1. Weigh each raw material according to the above alloy ratio;

[0039]S2. Put pure zinc (purity ≥ 99.995%) into a crucible with a coating on the inner wall, raise the temperature to 420°C and wait for the pure zinc to completely melt, then add Cu-containing raw materials when the zinc melt is heated to 520°C, and wait for the Cu-containing After the raw materials are completely melted, add LiCl and LiF mixed flux (mass ratio: 1:3) when the melt temperature rises to 590°C, and after the above mixed solvent completely covers the melt surface, then lower the melt temperature to 550°C, At this time, pure lithium (purity ≥ 99.999%) is added under the protection of Ar gas, and after the pure lithium is...

Embodiment 2

[0043] This embodiment relates to a degradable medical Zn-Li-X alloy material, which includes the following alloy components in weight percentage: Li is 10%, Mg is 0.1%, and the rest is Zn.

[0044] The preparation method of this alloy material is the same as embodiment 1, and difference is:

[0045] S2. Add Mg-containing raw materials when the zinc melt is heated to 500°C. After the Mg-containing raw materials are completely melted, add LiCl and LiF mixed flux (mass ratio is 1:3) when the melt temperature rises to 580°C. After the mixed solvent completely covers the surface of the melt, then lower the temperature of the melt to 540°C, and then add pure lithium under the protection of Ar gas;

[0046] S3. The refining temperature is 530±10°C, and the amount of hexachloroethane is 0.2% of the total weight of the alloy melt; after refining, stand still at 530±10°C for 30 minutes;

[0047] S4. The homogenization treatment temperature is 320°C, and the treatment time is 10 hours;...

Embodiment 3

[0049] This embodiment relates to a degradable medical Zn-Li-X alloy material, which includes the following alloy components in weight percent: Li is 2%, Cu is 1%, Mn is 0.05%, and the rest is Zn.

[0050] The preparation method of this alloy material is the same as embodiment 1, and difference is:

[0051] S2. Add Cu and Mn-containing raw materials when the zinc melt is heated to 580°C. After the Cu and Mn-containing raw materials are completely melted, add LiCl and LiF mixed flux (mass ratio is 1:3) when the melt temperature rises to 620°C. ), after the above-mentioned mixed solvent completely covers the surface of the melt, the temperature of the melt is lowered to 560°C, and pure lithium is added under the protection of Ar gas at this time;

[0052] S3. The refining temperature is 550±10°C, and the amount of hexachloroethane is 0.3% of the total weight of the alloy melt; after refining, stand still at 550±10°C for 10 minutes;

[0053] S4. The homogenization treatment temp...

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Abstract

The invention discloses a biodegradable medical Zn-Li-X series alloy material and a preparation method and application. The alloy material comprises 0.1-10 wt.% of Li, 0.01-4 wt.% of X and the balance Zn. X refers to at least one element of Cu, Ag, Mn, Mg, Si, Ca and Sr. Thermoplastic deformation processing is further required before smelted alloy is used, the alloy structure is refined, and thus alloy performance is improved. The zinc alloy has the advantages of excellent comprehensive mechanical property, good biocompatibility, regulatory degradation rate and the like and thus can be used as a material for preparing biodegradable medical implantation instruments to be applied to preparation of intravascular stents, bone implants, maxillofacial surgery and craniocerebral surgery implantation instruments, surgical sutures, various sorts of surgical patches, anastomats, vascular clamps or neural restoration catheters and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a biodegradable medical Zn-Li-X alloy material and its preparation method and application. Background technique [0002] At present, the medical materials implanted into the human body are generally made of non-degradable metal materials, such as (1) austenitic stainless steel (316LSS); (2) cobalt-chromium alloy; (3) medical tantalum; (4) titanium and Its alloy; (5) nickel-titanium shape memory alloy; (6) platinum-iridium alloy. The application of these permanent implant materials has the following disadvantages, for example (1) after the permanent metal vascular stent is implanted into the human body, due to its non-degradability, there is a shortcoming of easily forming thrombus to cause restenosis and intimal fibrosis in the stent, and the stent It remains permanently in the body and cannot be taken out again. Once the blood vessel is blocked again at the same position, it...

Claims

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Application Information

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IPC IPC(8): C22C18/00C22C18/02C22C1/02C22C1/06C22F1/16A61L17/06A61L27/04A61L27/58A61L31/02A61L31/14
CPCC22C18/00A61L17/06A61L27/047A61L27/58A61L31/022A61L31/148A61L2430/02A61L2430/32C22C1/02C22C1/06C22C18/02C22F1/165
Inventor 袁广银岳锐黄华
Owner SHANGHAI JIAO TONG UNIV
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