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A kind of multifunctional nanocomposite material and its preparation method and application

A nanocomposite material and a multifunctional technology, applied in the field of multifunctional nanocomposite materials and their preparation, can solve the problems of easy quenching of near-infrared fluorescent dyes, poor tissue penetration, low sensitivity, etc., and achieve a significant heating effect. , good imaging contrast, simple synthesis process

Active Publication Date: 2019-05-07
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Optical imaging is easy to operate and low in cost. It can be combined with a simple, non-destructive, real-time and portable operating system to better serve the clinic. However, it has low sensitivity, poor tissue penetration, and near-infrared fluorescent dyes are prone to quenching
MRI has the advantages of high spatial and temporal resolution, good contrast, good soft tissue imaging, and simultaneous acquisition of anatomical and physiological information, but it also has the disadvantage of low sensitivity.
Although photoacoustic imaging combines the advantages of high contrast characteristics of pure optical imaging and high penetration depth characteristics of pure ultrasound imaging, its resolution is not as high as that of MRI.

Method used

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  • A kind of multifunctional nanocomposite material and its preparation method and application
  • A kind of multifunctional nanocomposite material and its preparation method and application
  • A kind of multifunctional nanocomposite material and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0043] (1), Synthesis of Ag nanocube

[0044] Prepare the following solutions respectively:

[0045] 0.36mmol / L PVP solution (molecular weight 55000, take 125mg, dissolve in 6.25mL diethylene glycol);

[0046] 3mmol / L Na 2 S solution (take 10mg, dissolve in 1mL diethylene glycol, take out 0.1mL, dilute to 1mL with diethylene glycol);

[0047] 30mmol / L HCl solution (take 25μL 38% concentrated HCl, dissolve in 10mL diethylene glycol, take out 0.25mL before use, dilute to 0.5mL with diethylene glycol); 0.28mol / L CF 3 COOAg solution (take 125mg, dissolve in 2mL diethylene glycol).

[0048] In a 100mL round bottom flask, add 25mL of diethylene glycol, and heat to 150°C under magnetic stirring. Add 300 μL Na to diethylene glycol at 150 °C 2 S solution. After 4 min, 0.5 mL of HCl solution and 3 mL of PVP solution were added. After 2min, add 2mL CF 3 COOAg solution, react for 3h. After cooling, centrifuge and wash to obtain Ag nanocube of 20-30nm, its scanning electron micros...

Embodiment 2

[0053] Weigh 3.5mg of iridium 2-phenylquinoline-3,3'-bipyridinedicarboxylate and dissolve in 5mL DMSO to prepare iridium 2-phenylquinoline-3,3'-bipyridinedicarboxylate solution ; Weigh 2.1mg dysprosium acetate and dissolve in 2mL DMSO to prepare dysprosium acetate solution.

[0054] Add 5mL of iridium 2-phenylquinoline-3,3'-bipyridinedicarboxylate solution to the single-necked flask, then add PVP (50mg, m.w.=55000), heat to 110°C and keep for 20min. Quickly add 2mL dysprosium acetate solution and react for 7h. After the reaction solution is cooled to room temperature, get the SH-PEG-NH obtained in Example 1 2 1mL of the wrapped Au nanocage was mixed with 2mL of the reaction solution, transferred to a dialysis bag, dialyzed for 5h, and centrifuged to obtain a multifunctional nanocomposite material, which was characterized by scanning electron microscopy as follows: image 3 , the particle size is 80-100nm.

[0055] Figure 4 It is a transmission electron microscope image of...

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Abstract

The invention belongs to the technical field of inorganic nano materials and molecular imaging and in particular relates to a multifunctional nanocomposite as well as a preparation method and application thereof. The preparation method comprises the following steps: adding SH-PEG-NH2 into a gold nanocage wrapped by PVP on the surface, stirring for 8-20 hours, centrifuging, and washing, so that the gold nanocage wrapped by SH-PEG-NH2 on the surface is obtained; adding PVP into iridium 2-phenylquinoline-3,3'-bipyridine dicarboxylic acid solution, heating to 100-120 DEG C, and maintaining for 10-40 minutes; quickly dropwise adding dysprosium acetate solution, and reacting, so that reaction liquid is obtained; mixing the gold nanocage wrapped by SH-PEG-NH2 with the reaction liquid, carrying out dialysis reaction, centrifuging, and washing. The multifunctional nanocomposite provided by the invention can serve as a photoacoustic imaging / optical imaging / magnetic resonance imaging contrast agent and also has the function of carrying out photothermal therapy and photodynamic therapy, so that the multifunctional nanocomposite provided by the invention is a nano material which realizes integration of tumour diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of inorganic nanometer materials and molecular imaging, and specifically relates to a multifunctional nanocomposite material and its preparation method and application. Background technique [0002] In recent years, gold nanomaterials have shown great potential and advantages in the diagnosis and treatment of cancer due to their superior physical and chemical properties. The application of gold nanomaterials in the field of biomedicine is based on its attractive optical properties, especially the specific scattering and absorption of excitation light resonance wavelengths caused by plasmon resonance. Gold nanomaterials provide a versatile and multilayered platform for a variety of biomedical applications. Recent studies have also confirmed that gold nanomaterials can indeed be used in the diagnosis and treatment of cancer. For example, gold nanomaterials can be used as a substrate for optical detection of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/69A61K9/14A61K47/10A61K49/00A61K49/18A61K49/22A61P35/00
CPCA61K41/0052A61K49/0002A61K49/189A61K49/228
Inventor 杨仕平阎聪洋崔丽丽杨琪张晓芬潘立星杨红
Owner SHANGHAI NORMAL UNIVERSITY
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