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Component with liver protection effect and application thereof to prevention and control of non-alcoholic fatty liver

A liver-protecting, non-alcoholic technology, applied in the field of black wolfberry extract, can solve problems such as unclear effects and potential mechanisms, achieve significant social and economic benefits, promote intensive processing and utilization, and achieve high-value transformation.

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For consumers, a variety of foods from different origins, species, or processing methods are widely available, but the effects of these substances on hepatic fat accumulation and the underlying mechanisms are not clear

Method used

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  • Component with liver protection effect and application thereof to prevention and control of non-alcoholic fatty liver
  • Component with liver protection effect and application thereof to prevention and control of non-alcoholic fatty liver
  • Component with liver protection effect and application thereof to prevention and control of non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1 An extract with liver protection function, the main raw material is natural food source black wolfberry.

[0056] The preparation method is as follows: weigh black wolfberry, extract with ethanol with a volume fraction of 50-70% at a solid-liquid ratio of 1:1-1:20, extract at a temperature of 30-100°C, and extract for more than 15 minutes , after filtering, take the filtrate, extract 1-5 times, combine all the filtrates and carry out low-temperature vacuum concentration to a gelatinous paste, remove all ethanol and almost all water, and then dilute with water to obtain an aqueous solution of the extract. The extract is diluted with 1.5-2.0 ml of water.

[0057] figure 1 It is the technological process for the preparation of black wolfberry extract, which summarizes the above-mentioned preparation methods.

Embodiment 2

[0059] The effect of embodiment 2 black wolfberry extract on mouse body weight and food intake

[0060] Male mice aged 6-8 weeks were randomly divided into 4 groups: normal control group, model control group, black wolfberry group, and simvastatin group. 10 mice per group. Except for the blank control group fed with common feed, the other three groups were fed with high-fat nutritious feed. The black wolfberry group and the simvastatin group were fed with high-fat feed at the same time with concentrated black wolfberry extract and simvastatin aqueous solution. Mouse body weight and diet.

[0061] Measuring method of mouse body weight and food intake: monitor with electronic balance and calculate the difference.

[0062] figure 2 It is a comparison of the changes in the weight gain of mice after feeding them with black wolfberry extract. image 3 It is the change of food intake of mice after feeding with black wolfberry extract. Depend on figure 2 and image 3 It can b...

Embodiment 3

[0063] Example 3 Effect of black wolfberry on mouse liver morphology, liver-to-body ratio and fat-to-body ratio

[0064] Obesity is closely related to fatty liver. It has been reported that mild fatty infiltration in the liver can be found in about half of obese patients, and the incidence of fatty liver in severely obese patients can reach 61% to 94%. The accumulation of fat in the liver is positively correlated with the degree of excessive body weight. The body shape characteristics of obese patients also have a certain impact on the formation of fatty liver. The invention calculates the liver-to-body ratio and the fat-to-body ratio by weighing the liver weight, epididymis fat weight and body weight, and takes pictures of the tissue morphology of mice.

[0065] Figure 4 It is the morphology of the tissue after the treatment of mice with black wolfberry. It can be seen that the change of body weight is not consistent with the phase of liver lesions and the change of liver ...

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Abstract

The invention relates to lycium ruthenicum extract with a liver protection function and evaluation of an inhibition effect of the lycium ruthenicum extract to non-alcoholic fatty liver and belongs to the field of biomedicines. A main raw material is natural food-borne lycium ruthenicum; a preparation method comprises: weighing the lycium ruthenicum; extracting the lycium ruthenicum with ethanol with the concentration of 50 percent to 70 percent according to the material-liquid ratio ranging from (1 to 1) to (1 to 20), wherein the extracting temperature is 30 DEG C to 100 DEG C and the extracting time is more than 15 minutes; after filtering, taking filtrate and repeating for 1 to 5 times; combining the obtained filtrate and concentrating at low temperature and in vacuum to obtain the extract. Mice which are fed by high fat are fed with the extract by gavage and an inhibition effect on the non-alcoholic fatty liver is evaluated; the extract can obviously inhibit the non-alcoholic fatty liver caused by high fat diet and complicated metabolic diseases is proved; the lycium ruthenicum extract has a remarkable liver function protection effect.

Description

technical field [0001] The invention relates to a black wolfberry extract capable of protecting the liver and its application in the inhibition of non-alcoholic fatty liver, belonging to the fields of biomedicine and food. Background technique [0002] With the continuous improvement of people's living standards and the transformation of working methods, fatty liver has become a common metabolic disease. Fatty liver refers to the lesion of excessive accumulation of fat in liver cells due to various reasons, and is accompanied by various complications, such as diabetes, cardiovascular disease, hormone disorders, and certain types of tumors. Fatty liver disease is a serious threat to the health of Chinese people, and lipogenesis is an important cause of non-alcoholic fatty liver. The promotion or inhibition of lipogenesis has a very significant impact on individual physiological functions. Drugs have different side effects on the human body. Therefore, finding functional ing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P1/16A23L33/105
CPCA61K36/815A23V2002/00A61K2236/333A61K2236/39A61K2236/51A61K2236/53A23V2200/32A23V2250/21
Inventor 何钊于月媛吴海兰臧瑾
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