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Chinese herbal medicine compound cream agent for treating fever in children and preparing method thereof

A compound cream, a technology for children's fever, applied in antipyretics, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of kidney and central system damage, children's unwillingness to cooperate with medicines, and children's digestive enzymes damage, etc. To achieve the effect of non-toxic side effects, stable texture and fast onset

Inactive Publication Date: 2017-01-04
QIQIHAR MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral administration of western medicines such as paracetamol and ibuprofen has certain curative effects, but it is unsafe for pediatrics. It will cause damage to the kidneys and central system, especially fever caused by diarrhea, if it is caused by dehydration Kidney damage is more serious, even irreversible
Traditional Chinese medicine has a certain curative effect in treating children with cold and fever, but most of them are oral or injection preparations. Due to the disadvantages of bitter taste, pain, and inconvenient administration, children are often unwilling to cooperate with medication, and oral medication can easily cause the destruction of digestive enzymes in children and Stimulation, and the first-pass effect of the liver, both affect the efficacy of the drug and have certain side effects
At present, traditional Chinese medicine preparations that use external therapy to treat high fever in children include enemas, patches, film coatings, and rectal instillations, etc., but often due to the limitation of excipients and unknown drug ingredients, the drug dosage is too large, resulting in inaccurate curative effect

Method used

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  • Chinese herbal medicine compound cream agent for treating fever in children and preparing method thereof
  • Chinese herbal medicine compound cream agent for treating fever in children and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The raw materials of a traditional Chinese medicine compound cream for treating fever are: Bupleurum 50 g, Guizhi 15 g, Nepeta 15 g, Artemisia annua 15 g, Asarum 15 g, Honeysuckle 15 g, and Scutellaria baicalensis 50 g.

[0030] (1) First, weigh the above-mentioned raw materials of traditional Chinese medicine and extract them according to the following method:

[0031] ① Put the above-mentioned medicinal materials through a 30-mesh sieve and place them in a flask, add 12 times the amount of 30% ethanol aqueous solution, and extract by steam distillation for 6 hours, and collect the volatile oil and water decoction respectively;

[0032] ② Concentrate the water decoction to 400 mL under reduced pressure;

[0033] ③ Add the above-mentioned volatile oil, 0.1 g of menthol, and 0.1 g of borneol to the concentrated 400 mL decoction;

[0034] (2) Preparation of oil phase: put 30 g of cetyl alcohol, 20 g of white petrolatum, 30 g of glyceryl monostearate, and 20 mL of PEG-8 b...

Embodiment 2

[0039] A traditional Chinese medicine compound cream for the treatment of mammary gland hyperplasia consists of the following raw materials: Bupleurum 35g, Guizhi 10g, Nepeta 10g, Artemisia annua 10g, Asarum 10g, Honeysuckle 10g, and Scutellaria baicalensis 35g.

[0040] (1) First, weigh the above-mentioned raw materials of traditional Chinese medicine and extract them according to the following method:

[0041] ① Put the above-mentioned medicinal materials through a 30-mesh sieve and place them in a flask, add 12 times the amount of 30% ethanol aqueous solution, steam distillation for 6 hours, and collect the volatile oil and water decoction respectively;

[0042] ② Concentrate the water decoction to 400 mL under reduced pressure;

[0043]③ Add the above-mentioned volatile oil, 0.1 g of menthol, and 0.1 g of borneol to the concentrated 400 mL decoction;

[0044] (2) Preparation of oil phase: put 30 g of cetyl alcohol, 20 g of white petrolatum, 30 g of glyceryl monostearate, ...

Embodiment 3

[0049] A traditional Chinese medicine compound cream for the treatment of mammary gland hyperplasia consists of 42 g Bupleurum, 12 g Guizhi, 12 g Schizonepetae, 12 g Artemisia annua, 12 g Asarum, 12 g Honeysuckle, and 42 g Scutellaria baicalensis.

[0050] (1) First, weigh the above-mentioned raw materials of traditional Chinese medicine and extract them according to the following method:

[0051] ① Put the above-mentioned Chinese medicinal materials through a 30-mesh sieve and place them in a flask, add 12 times the amount of 30% ethanol aqueous solution, steam distillation for 6 hours, and collect the volatile oil and water decoction respectively;

[0052] ② Concentrate the water decoction to 400 mL under reduced pressure;

[0053] ③ Add the above-mentioned volatile oil, 0.1 g of menthol, and 0.1 g of borneol to the concentrated 400 mL decoction;

[0054] (2) Preparation of oil phase: put 30 g of cetyl alcohol, 20 g of white petrolatum, 30 g of glyceryl monostearate, and 20...

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PUM

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Abstract

The invention discloses a Chinese herbal medicine compound cream agent for treating fever in children and a preparing method thereof. The Chinese herbal medicine compound cream agent for treating fever in children is an oil-in-water type of cream agent, which is prepared from the following procedures: preparing the following medicinal materials, by weight, 35-50 g of Chinese thorowax root, 10-15 g of cassia twig, 10-15 g of ching-chieh, 10-15 g of sweet wormwood herb, 10-15 g of asarum, 10-15 g of honeysuckle and 35-50 g of scutellaria baicalensis, and adding 30% ethanol water 12 times the amount of the medicinal materials in the medicinal materials; distilling and extracting the mixture for 6 h and collecting the volatile oil and the water decoction; decompressing and enriching the water decoction to 400 mL, and adding the extracted volatile oil, 0.1 g of menthol and 0.1 g of borneol into the enriched water decoction. The oil-phase raw materials include cetanol, albolene, glycerin monostearate and PEG-8 beewax; and the water-phase raw materials include Sodium Lauryl Sulfgot, glycerinum and distilled water. Through a test, the Chinese herbal medicine compound cream agent for treating fever in children has the functions of clearing heat and relieving exterior syndrome, and receives a remarkable curative effect when being used clinically for treating fever caused by upper respiratory inflection and the like. The Chinese herbal medicine compound cream agent for treating fever in children is simple in preparing technology, exquisite and lubricant, good in transdermal effect, has no stimulation to skin, and avoids skin allergy phenomena and toxic and side effects of oral drugs.

Description

technical field [0001] The invention relates to a traditional Chinese medicine cream, in particular to a traditional Chinese medicine compound cream for treating fever in children, and also relates to a preparation method of the compound cream. Background technique [0002] Fever is the most common symptom of colds, inflammations and other diseases, especially upper respiratory tract infections in children. Due to the physiological and pathological characteristics of children, fever can easily lead to convulsions and aggravate the condition. At the same time, it is easy to be accompanied by lung inflammation. If the treatment is not timely, it is easy to cause acute nephritis, myocarditis and other difficult and serious diseases. Oral administration of western medicines such as paracetamol and ibuprofen has certain curative effects, but it is unsafe for pediatrics. It will cause damage to the kidneys and central system, especially fever caused by diarrhea, if it is caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/107A61P29/00A61K31/045
CPCA61K9/107A61K31/045A61K36/233A61K36/268A61K36/282A61K36/355A61K36/538A61K36/539A61K36/54A61K2236/333A61K2236/51A61K2300/00
Inventor 洪博李文静
Owner QIQIHAR MEDICAL UNIVERSITY
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