High-stability diclazuril suspension and preparation method thereof

A diclazuril and high-stability technology, which is applied in the fields of pharmaceutical formula, liquid transportation, emulsion transportation, etc., can solve the problems of affecting appetite and growth rate, poor suspension stability, and susceptibility to temperature influence, etc., to achieve The effect of reducing animal gastrointestinal irritation, stable performance, and good low temperature stability

Inactive Publication Date: 2017-01-04
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Diclazuril suspension is convenient to take, but the existing suspension has poor stability and is easily affected by temperature. In addition, it significantly stimulates the gastrointestinal tract of animals, affecting their appetite and growth rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) 12g of chitosan was added to 100g of 3wt% acetic acid aqueous solution, after mixing evenly, 20g of diclazuril was added thereto, and 31.2g of diclazuril slow-release granules were obtained by spray drying.

[0023] (2) Add 15g of diclazuril sustained-release granules, 4g of polyethylene glycol 1000, 2g of polyoxyethylene sorbitan monooleate and 74g of water into the reaction vessel, and stir for 9 minutes at a stirring speed of 1000 rpm Mix evenly, then add 1g of polyoxyethylene polyoxypropanolamine ether, 3g of sodium chloride and 1g of vitamin E, and stir for 15 minutes at a stirring speed of 500 rpm.

[0024] The resulting diclazuril suspension has good stability without precipitation after being stored at room temperature for one year.

Embodiment 2

[0026] (1) Add 10 g of chitosan to 100 g of 3 wt % acetic acid aqueous solution, mix well, then add 22 g of diclazuril therein, and spray dry to obtain 31.4 g of diclazuril slow-release granules.

[0027] (2) Add 10g of diclazuril sustained-release granules, 3g of polypyrrolidone, 1g of Span 80 and 82.7g of water into the reaction vessel, stir for 10 minutes at a stirring speed of 800 rpm and mix well, then add 1.5g of polyoxygen Allyl glyceryl ether, 1 g of sodium chloride and 0.8 g of gallic acid were stirred at a stirring speed of 400 rpm for 20 minutes.

[0028] The resulting diclazuril suspension has good stability without precipitation after being stored at room temperature for one year.

Embodiment 3

[0030] (1) Add 15 g of chitosan to 100 g of 3 wt % acetic acid aqueous solution, mix well, then add 25 g of diclazuril therein, and spray dry to obtain 38.6 g of diclazuril slow-release granules.

[0031] (2) Add 20g diclazuril sustained-release granules, 5g sodium hydroxymethylcellulose, 3g polyoxyethylene sorbitan monooleate and 66.8g water into the reaction vessel, and stir at a stirring speed of 1200 rpm Mix evenly for 8 minutes, then add 2g of polydimethylsiloxane, 2g of sodium chloride and 1.2g of tea polyphenols and stir for 18 minutes at a stirring speed of 600 rpm.

[0032] The resulting diclazuril suspension has good stability without precipitation after being stored at room temperature for one year.

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PUM

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Abstract

The invention provides a high-stability diclazuril suspension and a preparation method thereof. The high-stability diclazuril suspension is prepared from, by weight, 10-20 parts of diclazuril slow-release particles, 3-5 parts of suspending agent, 1-3 parts of dispersing agent, 1-2 parts of defoamer, 1-3 parts of sodium chloride, 0.8-1.2 parts of antioxidant and 66.8-82.7 parts of water. The preparation method of the diclazuril slow-release particles includes the following steps that chitosan is dissolved in a 3wt% acetic acid water solution, a solution A is prepared, diclazuril is added into the solution A, and after the materials are stirred and mixed to be uniform, the diclazuril slow-release particles are prepared through spray drying. The high-stability diclazuril suspension has good low-temperature stability, is stable in performance after being stored for a year, and is conveniently put into use; the slow release effect is achieved, and irritation of medicine to animal stomachs and intestines is reduced.

Description

technical field [0001] The invention relates to a veterinary drug preparation, in particular to a highly stable diclazuril suspension and a preparation method thereof. Background technique [0002] Diclazuril is a triazine benzyl nitrile compound, also known as Diclazuril, Saccharin, and Keliqin. It is a new generation of anticoccidial drugs developed by the Belgian Janssen Pharmaceutical Factory in the 1980s. The chemical name is 2,6-dichloro-2-(4-chlorobenzene)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazine-2(3H) -base) phenylacetonitrile, also known as chlorazine acetonitrile. Molecular formula is C 17 h 9 C l3 N 4 o 2 , the molecular weight is 407.64. The drug is off-white or light yellow powder, almost odorless, slightly soluble in N,N-dimethylformamide (DMF), slightly soluble in tetrahydrofuran (THF), almost insoluble in water and ethanol, with a melting point of 291 -297°C. [0003] Diclazuril is a new type, high-efficiency, low-toxic anticoccidial drug, widely used...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/53A61K47/36A61K47/02A61P33/02
CPCA61K9/10A61K9/0002A61K9/0053A61K31/53A61K47/02A61K47/36
Inventor 聂月美王贤玉张丽佳邱洪左纯子
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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