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Temperature sensitive material preparation method

A temperature-sensitive material, lactic acid technology, applied in the field of temperature-sensitive materials, can solve the problems of achieving the best, reducing the temperature-sensitive properties of materials, and not being able to have both biocompatibility and temperature-sensitive properties.

Inactive Publication Date: 2016-12-21
HEBEI UNIVERSITY
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Problems solved by technology

Through the modification methods in the prior art, the biocompatibility of thermosensitive polymer materials can be improved or enhanced to a certain extent, but it brings two difficult technical problems: first, due to the carbon chain type thermosensitive In the presence of polymers, the modified material itself still does not have the best biocompatibility; second, because of the introduction of non-temperature-sensitive natural polymers, the temperature-sensitive properties of the modified materials will also vary with the natural polymers. decrease, or even disappear completely
[0004] Therefore, it is impossible to combine good biocompatibility and temperature-sensitive properties at the same time through the modification method of carbon-chain thermosensitive polymers and natural polymers.
In other words, the modified polymer material cannot have excellent biocompatibility and temperature-sensitive properties at the same time, that is, it cannot achieve the best of both properties.

Method used

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preparation example Construction

[0028] The invention provides a method for preparing a temperature-sensitive material, comprising the following steps:

[0029] Dehydrating lactic acid to obtain dehydrated lactic acid;

[0030] The anhydrous lactic acid and alanine are subjected to a copolymerization reaction under the condition of a catalyst to obtain a temperature-sensitive material.

[0031] In the present invention, lactic acid is dehydrated to obtain dehydrated lactic acid. The present invention has no special requirements on the source of the lactic acid, and lactic acid well known to those skilled in the art can be used, specifically, a commercially available product of lactic acid. In the present invention, the lactic acid contains 10-15% water. The present invention has no special requirements on the configuration of the lactic acid, specifically, it can be one, two or three of L-type lactic acid, D-type lactic acid and DL-type lactic acid.

[0032] In the present invention, the dehydration temper...

Embodiment 1

[0064] (1) Dehydration and pre-polymerization stage

[0065] In a microwave reactor (CEM microwave synthesizer, DISCOVER SP, power 150w, stirring rate High), 5.04g of lactic acid was placed in a 100mL long-necked flask, and a magnetic stirrer was placed. After 30 minutes of treatment at a vacuum of 0.065MPa and a temperature of 120°C, impurities such as water in the system can be removed. Then, add 4.2036g of alanine, 0.056g of stannous chloride and 0.047g of p-toluenesulfonic acid into the reaction flask, and react for 45 minutes at a vacuum degree of 0.083MPa and a temperature of 160°C.

[0066] (2) Polymerization stage

[0067] The reaction was continued at a vacuum of 0.088 MPa and a temperature of 170° C. for 30 minutes.

[0068] (3) Insulation stage

[0069] The reaction was maintained for 60 minutes at a vacuum of 0.085 MPa and a temperature of 160°C. When the reaction temperature drops below 50°C, fully dissolve it with 8mL of anhydrous methanol, then add it dropwi...

Embodiment 2

[0076] (1) Dehydration and pre-polymerization stage

[0077] In a microwave reactor (CEM microwave synthesizer, DISCOVER SP, power 150w, stirring rate High), 5.18g of lactic acid was placed in a 100mL long-necked flask, and a magnetic stirrer was placed. React for 40 minutes at a vacuum of 0.076 MPa and a temperature of 125° C. to remove free water in the reaction solution. Then, add 3.82g of alanine, 0.06g of stannous chloride and 0.05g of p-toluenesulfonic acid into the reaction flask, and react for 50 minutes at a vacuum degree of 0.092MPa and a temperature of 165°C.

[0078] (2) Polymerization stage

[0079] The reaction was continued at a vacuum of 0.089 MPa and a temperature of 175° C. for 40 minutes.

[0080] (3) Insulation stage

[0081] The reaction was maintained for 65 minutes at a vacuum of 0.090 MPa and a temperature of 170°C. When the reaction temperature drops below 50°C, fully dissolve it with 12mL of anhydrous methanol, then dropwise add it into 180mL of die...

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Abstract

The present invention provides a temperature sensitive material preparation method, which comprises: dehydrating lactic acid to obtain dehydrated lactic acid; and carrying out a copolymerization reaction on the dehydrated lactic acid and alanine under a catalyst condition to obtain the temperature sensitive material. Compared to the existing temperature sensitive polymer material, the temperature sensitive material of the present invention has the following characteristic that the natural bio-friendly alanine and the lactic acid are adopted as the polymerization monomers to directly copolymerize to prepare the polymer material having the temperature sensitive property. The temperature sensitive material of the present invention has excellent temperature sensitivity and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of temperature-sensitive materials, in particular to a preparation method of temperature-sensitive materials. Background technique [0002] Temperature-sensitive polymer materials refer to macromolecules that have reversible response characteristics to the external environment temperature, and are a very important smart material. Thermosensitive polymer materials have been widely used in biomedical fields such as controlled drug release, bioseparation, enzyme immobilization, and immunoassay. One of the most important physical parameters of temperature-sensitive polymer materials is the lowest critical solution temperature (LCST) or the highest critical solution temperature (UCST), that is, the temperature at which the polymer reversibly undergoes a significant phase change with temperature changes in aqueous solution. The practical application of temperature-sensitive polymer materials must involve two most...

Claims

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Application Information

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IPC IPC(8): C08G69/44
CPCC08G69/44
Inventor 邓奎林郑畅宋计花范智慧徐俊连杨震赵漫
Owner HEBEI UNIVERSITY
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