A kind of membrane emulsifier and emulsion preparation method

Abstract

The invention provides a membrane emulsifier and an emulsion preparation method, which relate to the field of membrane emulsification. The device includes: a stable pressure supply device and a membrane emulsification device. The membrane emulsification device includes a conventional membrane emulsification device and a high-flux membrane emulsification device. The conventional membrane emulsification device The high-flux membrane emulsification device is connected to the stable pressure supply device through double valves, the stable pressure supply device is a liquid flow control device, and the stable pressure supply device includes a flow meter, a dispersed phase feed device and a constant flow pump. The invention replaces the gas pressure control of the existing membrane emulsifier with liquid flow control, avoids the use of nitrogen bottles, simplifies equipment accessories, and facilitates the operation and transportation of the instrument; realizes precise regulation of the transmembrane pressure and improves the stability of the transmembrane pressure , to ensure the particle size uniformity and batch repeatability of the droplets, which is conducive to standardized and large-scale production, the preparation process has mild conditions, and can be used for the embedding of biologically active substances or unstable drugs, etc., with a wide range of applications.

Description

technical field [0001] The invention provides a membrane emulsifier and emulsion preparation method with precise controllable pressure, stable pressure and easy operation, and relates to the field of membrane emulsification. Background technique [0002] Emulsification is an important unit operation in the fields of chemistry, chemical industry, light industry, food, medicine, biochemistry and so on. At present, methods such as mechanical stirring, homogenization, and ultrasound are generally used to prepare emulsions and microspheres. Although the process conditions are simple, the particle size uniformity is poor, the particle size is difficult to control, and the experiment repeatability is poor. [0003] In order to prepare emulsions and nanosphere products with uniform particle size, membrane emulsification technology has developed rapidly in recent years. This technology can not only control the particle size of the emulsion during the preparation process, but also ha...

AI Technical Summary

Problems solved by technology

If the membrane pressure is too high, the dispersed phase will be sprayed into the continuous phase to form large-sized emulsion droplets; if the membrane pressure is too small, the membrane emulsification process will take too long, affecting production efficiency

Moreover, as the emulsification proceeds, the decrease in the liquid level of the dispersed phase will cause pressure fluctuations

At the same time, pressure control such as pressurization and pressure relief of the emulsifier are all manual operations, which can easily lead to unstable pressure

At the same time, the pressure required for the preparation of large particle size microspheres using a membrane emulsifier is very low, which requires high precision of the pressure gauge and pressure stability, which poses a great challenge to the instrument operator

[0005] Chinese patent document 200810223283.0 (notification number CN101683592) discloses a membrane emulsifier, including a membrane module, a dispersed phase feed tank, a constant pressure feed device and a continuous phase feed tank; The horizontal batch repeatability has effectively improved the quality of the emulsion, but the pressure supply device of the membrane emulsifier still adopts the gas supply pressure method, and the pressure is unstable. Generally, it is a device imported from abroad, the price is relatively expensive, which increases the cost of the instrument and makes it difficult to realize industrialization

[0006] The main disadvantage of the prior art is that the transmembrane pressure of the dispersed phase is derived from the gas pressure, its size is adjusted manually, and the accuracy and stability of the pressure are difficult to control, so that the particle size and batch repeatability of the microspheres are affected by the instrument operator. It is difficult to carry out standardized and large-scale production

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