Film emulsifying device and emulsion preparation method

Abstract

The invention provides a film emulsifying device and an emulsion preparation method, and relates to the field of film emulsifying. The device comprises a stable pressurization device and a film emulsifier. The film emulsifier comprises a conventional film emulsifier and a high-throughput film emulsifier which are connected with the stable pressurization device through double valves respectively. The stable pressurization device is a liquid flow control device and comprises a flow meter, a dispersion phase feeding device and a constant-flow pump. Liquid flow control is used for replacing gas pressure control of an existing film emulsifying device, no nitrogen cylinder is adopted, equipment accessories are simplified, and instrument operation and conveying are convenient; film-cross pressure is accurately adjusted and controlled, film-cross pressure stability is improved, particle diameter uniformity and batch repeatability of liquid drops are ensured, standardized large-scale production can be conveniently carried out, the conditions of the preparation process are mild, and the film emulsifying device can be used for embedding and the like of bioactive substance or unstable medicine and is wide in application range.

Description

Technical field [0001] The invention provides a membrane emulsifier with accurate pressure control, stable pressure and simple operation and an emulsion preparation method, and relates to the field of membrane emulsification. Background technique [0002] Emulsification is an important unit operation in the fields of chemistry, chemical industry, light industry, food, medicine, and biochemistry. At present, emulsions and microspheres are generally prepared by mechanical stirring, homogenization, and ultrasound. Although the process conditions are simple, the particle size uniformity is poor, the particle size is difficult to control, and the experiment repeatability is poor. [0003] In order to prepare emulsions and nanospheres with uniform particle size, membrane emulsification technology has developed rapidly in recent years. This technology can not only control the particle size of the emulsion during the preparation process, but also has uniform particle size distribution, mi...

AI Technical Summary

Problems solved by technology

If the membrane pressure is too high, the dispersed phase will be sprayed into the continuous phase to form large-sized emulsion droplets; if the membrane pressure is too small, the membrane emulsification process will take too long, affecting production efficiency

Moreover, as the emulsification proceeds, the decrease in the liquid level of the dispersed phase will cause pressure fluctuations

At the same time, pressure control such as pressurization and pressure relief of the emulsifier are all manual operations, which can easily lead to unstable pressure

At the same time, the pressure required for the preparation of large particle size microspheres using a membrane emulsifier is very low, which requires high precision of the pressure gauge and pressure stability, which poses a great challenge to the instrument operator

[0005] Chinese patent document 200810223283.0 (notification number CN101683592) discloses a membrane emulsifier, including a membrane module, a dispersed phase feed tank, a constant pressure feed device and a continuous phase feed tank; The horizontal batch repeatability has effectively improved the quality of the emulsion, but the pressure supply device of the membrane emulsifier still adopts the gas supply pressure method, and the pressure is unstable. Generally, it is a device imported from abroad, the price is relatively expensive, which increases the cost of the instrument and makes it difficult to realize industrialization

[0006] The main disadvantage of the prior art is that the transmembrane pressure of the dispersed phase is derived from the gas pressure, its size is adjusted manually, and the accuracy and stability of the pressure are difficult to control, so that the particle size and batch repeatability of the microspheres are affected by the instrument operator. It is difficult to carry out standardized and large-scale production

Images