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Preparation method of cellulose and fibroin composite small-caliber artificial blood vessel material

A technology of artificial blood vessels and cellulose, applied in the fields of medical formula, medical science, prosthesis, etc., can solve the problems of easy formation of thrombus, strong hydrophobicity, poor tissue compatibility, etc., and achieve the effect of expanding the range of raw materials and overcoming poor compliance

Inactive Publication Date: 2016-11-09
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are problems such as poor histocompatibility, strong hydrophobicity, and easy formation of thrombus, resulting in poor patency of artificial blood vessels, so it is not suitable for the preparation of small-caliber artificial blood vessels

Method used

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  • Preparation method of cellulose and fibroin composite small-caliber artificial blood vessel material
  • Preparation method of cellulose and fibroin composite small-caliber artificial blood vessel material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) After the bamboo pulp is dried, it is pulverized by a plant pulverizer and filtered through a 180-mesh screen to obtain the bamboo pulp powder with a particle size of 0.08 mm.

[0027] 2) Put the moso bamboo pulp powder obtained in step 1) under the action of mechanical stirring, and place it in a 1wt% cellulase solution at 60°C to react for 360 minutes. The mass ratio of the moso bamboo pulp powder to the cellulase solution is 1:1. 10 times the volume of the above-mentioned cellulase solution in distilled water to terminate the reaction, then centrifuged to wash away the residual enzyme, and at room temperature, the reacted mixture was packed into a dialysis bag with a molecular weight cut-off of 120k Da, and dialyzed in distilled water until the dialysis was Neutral solution, freeze-dried to obtain nano-microcrystalline cellulose.

[0028] 3) Dissolving the nano-microcrystalline cellulose obtained in step 2) in sodium hydroxide / urea solution, the mass fraction rati...

Embodiment 2

[0032] 1) After the bamboo pulp is dried, it is pulverized by a plant pulverizer and filtered through a 180-mesh screen to obtain the bamboo pulp powder with a particle size of 0.07 mm.

[0033] 2) Put the moso bamboo pulp powder obtained in step 1) under the action of mechanical stirring, and place it in 0.5wt% cellulase solution at 50°C to react for 450min, the mass ratio of moso bamboo pulp powder to cellulase solution is 1:1, Use room temperature distilled water 10 times the volume of the above-mentioned cellulase solution to terminate the reaction, then centrifuge to wash away the residual enzyme, and put the reacted mixture into a dialysis bag with a molecular weight cut-off of 120kDa at room temperature, and dialyze in distilled water until the dialysis It is a neutral solution and freeze-dried to obtain nanocrystalline cellulose.

[0034] 3) Dissolving the nano-microcrystalline cellulose obtained in step 2) in sodium hydroxide / urea solution, the mass fraction ratio of so...

Embodiment 3

[0038] 1) After the bamboo pulp is dried, it is pulverized by a plant pulverizer and filtered through a 180-mesh screen to obtain the bamboo pulp powder with a particle size of 0.06 mm.

[0039] 2) Put the moso bamboo pulp powder obtained in step 1) under the action of mechanical stirring, and place it in a 2wt% cellulase solution at 70°C to react for 270min. The mass ratio of the moso bamboo pulp powder to the cellulase solution is 1:2. Terminate the reaction with distilled water at room temperature 10 times the volume of the above enzyme solution, then centrifuge to wash away the residual enzyme, and put the reacted mixture into a dialysis bag with a molecular weight cut-off of 120k Da at room temperature, and dialyze in distilled water until the dialysis becomes neutral solution, freeze-dried to obtain nanocrystalline cellulose.

[0040] 3) Dissolving the nano-microcrystalline cellulose obtained in step 2) in sodium hydroxide / urea solution, the mass fraction ratio of sodium...

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Abstract

The invention discloses a preparation method of a cellulose and fibroin composite small-caliber artificial blood vessel material. The method is characterized by including the steps of hydrolyzing phyllostachys heterocycla pulp powder through cellulase, conducting oxidization through sodium periodate to prepare nanometer dialdehyde cellulose, and adding the nanometer dialdehyde cellulose to a fibroin solution for mixing reaction to establish the ideal small-caliber artificial blood vessel material. The blood vessel material comprehensively uses the high mechanical strength of nanocrystalline cellulose and the good adaptability and biocompatibility of silk fibroin and provides a data basis for finding a suitable small-caliber blood vessel substitute material. Meanwhile, silk and phyllostachys heterocycla resources in the province can be fully used for preparing a high-additional-value biological medical new material, and the method is expected to be an innovative concept for using silk and phyllostachys heterocycla resources in a high-valued mode, and conforms to the national development circular economy policy.

Description

technical field [0001] The invention belongs to the field of organic macromolecule materials, and in particular relates to a preparation method of a cellulose and silk fibroin composite small-diameter artificial blood vessel material. Background technique [0002] Cardiovascular disease has become the number one killer with the highest cause of death in human beings, and it is the "silent evil spirit" of people's health. One and more" features. For the treatment of cardiovascular diseases, in addition to drugs, blood vessel transplantation or vascular bypass surgery is required in severe cases. Numerous practices have shown that most autologous saphenous veins and internal mammary arteries cannot be ideal sources of blood vessels due to their own vascular lesions and the limitation of the number of blood vessels in the human body. Therefore, the demand for small-caliber artificial blood vessel materials in clinical medicine is increasing. [0003] An ideal vascular materi...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/20A61L27/22
CPCA61L27/20A61L27/227A61L27/50A61L27/507A61L2400/12C08L1/04C08L89/00
Inventor 张勇麻景淇姚菊明
Owner ZHEJIANG SCI-TECH UNIV
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