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A kind of preparation method of medical bio-based composite hemostatic dressing

A hemostatic dressing, bio-based technology, applied in medical science, bandages, etc., can solve problems such as unsatisfactory hemostasis, secondary injury, wound adhesion, etc., and achieve the effect of accelerating wound coagulation and hemostasis, facilitating absorption, and rapid hemostasis.

Active Publication Date: 2019-08-06
SHANDONG ZHUSHI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: Aiming at the problem that the existing hemostatic dressing has unsatisfactory hemostatic effect, is easy to adhere to the wound, and often causes secondary damage when withdrawing, a method for preparing a medical bio-based composite hemostatic dressing is provided. The invention made the treated stamen powder by ball milling, sieving, roasting and other processes, and then mixed xanthan gum, sodium alginate, deionized water and freeze-dried thrombin powder to obtain thrombin-coated powder. Composite gel, and then use pigskin collagen powder as raw material to make collagen solution, use glutaraldehyde solution as crosslinking agent and composite gel coated with thrombin to carry out crosslinking reaction, and the reactant is freeze-dried and ground After sieving, mix it with stamen powder to get a composite hemostatic dressing. The medical bio-based composite hemostatic dressing of the present invention has better hemostatic effect and certain antibacterial effect, and the prepared dressing is in powder form and can be directly sprinkled on the wound , there is no problem of adhesion with the wound, causing secondary damage, good biocompatibility with the wound, and can be applied on a large scale

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] First, weigh 50g of stamens, put them into a ball mill and mill them for 15 minutes, pass through a 220-mesh sieve to obtain stamens powder, put the stamens powder into a crucible, place it in a muffle furnace, and raise the temperature to 120 at a rate of 3°C / min. °C, 200 °C, 500 °C and 700 °C, and heat-preserve and roast for 20 minutes respectively. After the final roasting, the powder is immediately added to tap water and quenched to room temperature. After quenching, the precipitate is separated by centrifugation and put into a vacuum oven. Dry it for 8 hours, grind it after drying, pass through a 280-mesh sieve, and get the treated stamen powder for later use; then weigh 5g xanthan gum and 10g sodium alginate in turn and add them to a 1000mL beaker, and add 500mL deionized water, stir and mix for 3 hours, add thrombin freeze-dried powder at 15 mg / mL to the mixture after standing, put it in a water bath, stir and mix for 3 hours at 37°C, and coat after mixing Compos...

example 2

[0020] First, weigh 55g of stamens, put them into a ball mill and mill them for 18 minutes, and pass through a 230-mesh sieve to obtain stamens powder. Put the stamens powder into a crucible, place it in a muffle furnace, and raise the temperature to 135 at a rate of 4°C / min. °C, 250 °C, 550 °C and 750 °C, and heat-preserve and roast for 25 minutes respectively. After the final roasting, the powder is immediately added to tap water and quenched to room temperature. After quenching, the precipitate is separated by centrifugation and put into a vacuum oven. After drying for 9 hours, after drying, it was ground and passed through a 290-mesh sieve to obtain the treated stamen powder for later use; then weighed 8g of xanthan gum and 13g of sodium alginate and added them to a 1000mL beaker, and added 550mL of deionized water, stirred and mixed for 4 hours, then added thrombin freeze-dried powder at 18mg / mL to the mixed solution after standing, put it in a water bath, stirred and mixe...

example 3

[0023]First, weigh 60g of stamens, put them into a ball mill and mill them for 20 minutes and pass through a 240-mesh sieve to obtain stamens powder. Put the stamens powder into a crucible and place it in a muffle furnace, and raise the temperature to 150 at a rate of 5°C / min. °C, 300 °C, 600 °C and 800 °C, and heat-preserve and roast for 30 minutes respectively. After the final roasting, the powder was immediately added to tap water and quenched to room temperature. After quenching, the precipitate was separated by centrifugation and placed in a vacuum oven. Dry it for 10 hours, grind it after drying, and pass through a 300-mesh sieve to obtain the treated stamen powder for later use; then weigh 10g xanthan gum and 15g sodium alginate in turn and add them to a 1000mL beaker, and add 600mL deionized water, stir and mix for 5 hours, add thrombin freeze-dried powder at 20 mg / mL to the mixture after standing, put it in a water bath, stir and mix for 4 hours at 37°C, and coat after...

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Abstract

The invention discloses a preparation method of a medical bio-based compound hemostatic dressing, belonging to the technical field of dressing preparation. The preparation method is characterized by preparing treated ophicalcite powder by ball-milling, sieving and roasting ophicalcite, then stirring and mixing xanthan gum, sodium alginate, deionized water and lyophilized powder of thrombin to obtain thrombin coated compound gel, then preparing a collagen solution by using pigskin collagen powder as the raw material, subjecting a glutaraldehyde solution as a cross-linking agent to cross-linking reaction with the thrombin coated compound gel, freeze-drying, grinding and sieving a reactant and then mixing the powder with the ophicalcite powder, thus obtaining the compound hemostatic dressing. The medical bio-based compound hemostatic dressing has better hemostatic effects and certain antibacterial effects, is powdery, is directly scattered on wounds, avoids the problem that the dressing adheres to the wounds, thus causing secondary injuries, has good biocompatibility with the wounds and can be applied on a large scale.

Description

technical field [0001] The invention discloses a preparation method of a medical bio-based composite hemostatic dressing, which belongs to the technical field of dressing preparation. Background technique [0002] Blood loss is one of the most important reasons for the death of the wounded. It is generally divided into internal bleeding and external bleeding. Internal bleeding is mostly due to organ rupture, and external bleeding is basically due to arteriovenous injury. If the bleeding can be stopped in time and effectively, it is very important to save the life of the wounded, stabilize the injury, and create conditions for follow-up treatment. Dressing, as a hemostatic material, refers to a protective covering on the wound, which can help control bleeding, prevent infection and absorb secretions. Hemostatic dressings are of great significance for timely hemostasis. [0003] During surgical operations or when the human body is subjected to external trauma, it is often nec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0033A61L26/0047A61L26/0061A61L26/0066A61L2300/254A61L2300/418C08L89/00C08L5/00C08L5/04
Inventor 朱坤福祝蕾郭迎庆王统军薛蕾
Owner SHANDONG ZHUSHI PHARMA GRP CO LTD
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