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Application of salvianolic acid A in preparation of drugs for treating acute kidney injury

A technology of acute kidney injury and salvianolic acid, applied in the field of application of salvianolic acid A in the preparation of drugs for the treatment of acute kidney injury, to achieve the effect of reducing kidney tissue damage, promoting the outcome of kidney disease, and improving the degree of ischemia and hypoxia

Inactive Publication Date: 2016-11-09
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the treatment of AKI by salvianolic acid A at home and abroad. It is of great practical significance to conduct related research and develop drugs that have a positive preventive effect on AKI.

Method used

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  • Application of salvianolic acid A in preparation of drugs for treating acute kidney injury
  • Application of salvianolic acid A in preparation of drugs for treating acute kidney injury
  • Application of salvianolic acid A in preparation of drugs for treating acute kidney injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 salvianolic acid A

[0043] 300 grams of salvianolic acid salt was diluted with water to a concentration of 1.0% (calculated as salvia magnesium acetate), adjusted to pH 6.0 with trisodium citrate, converted for 4 hours at 125°C and 0.15MPa, cooled to room temperature, and adjusted with hydrochloric acid. When the pH reaches 2.0-3.0, the content of salvianolic acid A is determined according to the law; the sample solution is passed through the HPD100 resin column, eluted with water and 25% ethanol solution (discarded), and then eluted with 40% ethanol solution to collect salvianolic acid A, according to the law Determine the content of salvianolic acid A, concentrate under reduced pressure until the concentration of salvianolic acid A is about 15.0-30.0mg / ml; the concentrated solution is passed through a CG161 resin column, and eluted with 20% ethanol solution (discarded) successively, and then washed with 35% ethanol solution Collect sal...

Embodiment 2

[0044] Example 2 Protective effect of salvianolic acid A on acute kidney injury caused by renal ischemia-reperfusion

[0045] 1. Administration

[0046] Male SD rats (body weight 220-250g) were fed adaptively for one week, and were randomly divided into 6 groups: normal group, sham operation group, ischemia-reperfusion injury model group, salvianolic acid A administration group (2.5, 5. 10mg / kg), start administration after grouping, the normal group, the sham operation group and the ischemia-reperfusion injury group were injected with the same amount of glucose through the tail vein respectively, and each dose group of salvianolic acid A was injected with the corresponding dose through the tail vein respectively. Drug. Once a day, continuous administration for 5 days, the operation began 2 hours after the fifth administration.

[0047] 2. Establishment of renal ischemia-reperfusion model

[0048] Rats were fasted without water for 12 hours before the operation (fasted 10 ho...

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Abstract

The present invention discloses application of salvianolic acid A in the preparation of drugs for treating acute kidney injury and belongs to the technical field of uses of traditional Chinese medicine effective ingredients. It is proved via pharmacodynamic experiments that salvianolic acid A can effectively relieve renal tubular necrosis and renal tubular microvascular endothelial cell injury, improve expression of vascular endothelium growth factors, inhibit the decrease in microvascular density, improve ischemic anoxic extent and thereby relieve rat renal tissue injury due to acute renal injury. Therefore, the salvianolic acid A may be used to prepare drugs for treating acute renal injury, thereby developing new uses of the salvianolic acid A.

Description

technical field [0001] The invention relates to the application of salvianolic acid A in the preparation of medicines for treating acute kidney injury, and belongs to the technical field of application of active ingredients of traditional Chinese medicines. Background technique [0002] Acute kidney injury (AKI) is one of the most common clinical emergencies. AKI is closely related to the mortality of patients, the occurrence of chronic kidney disease (CKD) and the rate of maintenance dialysis. According to reports, in acute and critically ill patients, the incidence of AKI is as high as 25%, and the mortality rate is 15-60%. AKI will prolong the length of hospitalization, increase medical expenses, and affect long-term renal function, which has become a global public health problem [1][2] . In my country, the incidence of AKI in hospitalized adult patients is as high as 11.6%, which significantly increases hospital mortality [2] . At the same time, the unrecognized AKI...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P13/12
CPCA61K31/216A61K36/537
Inventor 范华英刘珂杨明艳张作凯高振芳王学凯郎跃武
Owner YANTAI UNIV
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