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Full-degradable vascular stent for vascular disease treatment and production method of full-degradable vascular stent

A technology for vascular stents and vascular diseases, which is applied in the field of fully degradable vascular stents and its preparation, can solve problems such as hindering the recovery of vascular functions, and achieve the effects of convenient operation and use, stable performance, and low production cost

Active Publication Date: 2016-10-26
乐普(深圳)国际发展中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, degradable biomaterials are beginning to be used to prepare vascular stents to improve the shortcomings of metal stents. For example, metal stents cause permanent retention in the human body and patients need to take medicine for a long time and metal stents will hinder the recovery of vascular function.

Method used

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  • Full-degradable vascular stent for vascular disease treatment and production method of full-degradable vascular stent
  • Full-degradable vascular stent for vascular disease treatment and production method of full-degradable vascular stent
  • Full-degradable vascular stent for vascular disease treatment and production method of full-degradable vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The preparation method of the fully degradable vascular stent for the treatment of vascular diseases, comprising the following steps:

[0067] 1) Raw material preparation:

[0068] Taking polylactic acid as raw material A, the number-average molar molecular weight of polylactic acid is 100,000;

[0069] 2) Processed into pipes:

[0070] First, heat the raw material A to a molten state, and the heating temperature is 200 ° C. Fill the molten material into the pipe forming mold, and then naturally cool until the internal temperature of the material drops to room temperature, that is, it is processed into a cylindrical pipe; the processed cylinder Profile pipe, its outer diameter is 2mm, and the thickness of the pipe wall is 0.5mm;

[0071] 3) Pipe reinforcement and toughening:

[0072] First place the cylindrical pipe in a constant temperature oven at 60°C for 10 hours to promote the orderly formation of the crystal nucleus of the original structure of the material to ...

Embodiment 2

[0084] The preparation method of the fully degradable vascular stent for the treatment of vascular diseases, comprising the following steps:

[0085] 1) Raw material preparation:

[0086] Put the polylactic acid and polylactic acid-trimethylene carbonate copolymer into the twin-screw extruder in a ratio of 70:30 in mass ratio for blending and granulation to obtain raw material B; the twin-screw extruder blending and pelletizing temperature is 180℃, the speed is 20rpm;

[0087] Wherein, the number-average molar molecular weight of polylactic acid is 400,000, and the number-average molar molecular weight of polylactic acid-trimethylene carbonate copolymer is 50,000;

[0088] 2) Processed into pipes:

[0089] The raw material B is placed in a plastic extruder, and the raw material is heated to a molten state in the plastic extruder, and its heating temperature is 210 ° C, then the melt is extruded from the pipe forming die, and finally cooled naturally until the material is Wh...

Embodiment 3

[0103] The preparation method of the fully degradable vascular stent for the treatment of vascular diseases, comprising the following steps:

[0104] 1) Raw material preparation:

[0105] Taking polylactic acid as raw material A, the number-average molar molecular weight of polylactic acid is 100,000;

[0106] 2) Processed into pipes:

[0107] The raw material A and the polylactic acid-trimethylene carbonate copolymer are placed in two extrusion heads in the extruder, respectively, and the two substances are heated to a molten state in the two extrusion heads, respectively. The heating temperature is 180°C; the extruded pipe has two layers, the material of the inner layer is polylactic acid, and the material of the outer layer is polylactic acid-trimethylene carbonate copolymer; finally cooled naturally until the internal temperature of the material drops to room temperature, That is, it is processed into a cylindrical pipe; the outer diameter of the processed cylindrical pi...

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Abstract

The invention provides a full-degradable vascular stent for vascular disease treatment. The full-degradable vascular stent is consisted of a stent body which is shaped like a circular tube and coating covering the stent body; the surface of the stent body is of a hollow-out reticulate structure engraved by laser; image marking pieces are respectively arranged at two ends of the stent body, image marking holes are arranged in the image marking pieces, and imaging objects are arranged in the image marking holes. The production method of the full-degradable vascular stent includes the steps of 1), preparing raw materials; 2), processing the raw materials into tubular products; 3), strengthening and toughing the tubular products; 4), preparing the stent body; 5), pressing the imaging objects into the image marking holes; 6), producing the drug coating and top controlled-releasing layers. The stent body is produced by adopting full-degradable material, so that the stent body can be gradually and fully absorbed by a basal body after implantation, and the problem about long-term medication of patients is solved; the imaging objects are arranged at two ends of the stent body, so that tracing role of the imaging objects can be well played during interventional operation; 3), the production method is simple in production, low in production cost, and the vascular stent produced is stable in performance.

Description

technical field [0001] The invention belongs to the technical field of three types of medical devices, and in particular relates to a fully degradable vascular stent for the treatment of vascular diseases and a preparation method thereof. Background technique [0002] Since the world's first successful coronary intervention (PCI) in 1977, percutaneous coronary angioplasty has achieved rapid development, laying a solid foundation for the treatment of human coronary heart disease. [0003] In the technical field of stent treatment of vascular diseases, it has experienced three generations of technology. The initial technical product is a pure metal bare stent system, which uses a stent system made of inert metal to implant the blood vessel to achieve the purpose of treatment, but its technical defects are inexhaustible. The avoided result is the high rate of vascular restenosis after implantation. The second-generation technology is improved on its basis, and a degradable drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/16A61L31/18A61L31/06A61L31/10
CPCA61L31/06A61L31/10A61L31/148A61L31/16A61L31/18A61L2300/216A61L2300/602A61L2300/606A61L2420/08C08L67/04
Inventor 王亮李文龙陈彦良王明利高户生李守宗
Owner 乐普(深圳)国际发展中心有限公司
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