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Fully degradable vascular stent for treatment of vascular diseases and preparation method thereof

A vascular stent, fully degradable technology, applied in the field of three types of medical devices, can solve problems such as hindering the recovery of vascular function, and achieve the effects of convenient operation and use, stable performance and low production cost

Active Publication Date: 2019-02-26
乐普(深圳)国际发展中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, degradable biomaterials are beginning to be used to prepare vascular stents to improve the shortcomings of metal stents. For example, metal stents cause permanent retention in the human body and patients need to take medicine for a long time and metal stents will hinder the recovery of vascular function.

Method used

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  • Fully degradable vascular stent for treatment of vascular diseases and preparation method thereof
  • Fully degradable vascular stent for treatment of vascular diseases and preparation method thereof
  • Fully degradable vascular stent for treatment of vascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] A preparation method for a fully degradable vascular stent for treatment of vascular diseases, comprising the following steps:

[0067] 1) Raw material preparation:

[0068] Take polylactic acid as raw material A, and the number average molar molecular weight of polylactic acid is 100,000;

[0069] 2) Processing into pipes:

[0070] First heat the raw material A to a molten state, the heating temperature is 200 ° C, fill the molten material into the pipe forming mold, and then cool it naturally until the internal temperature of the material drops to room temperature, that is, it is processed into a cylindrical pipe; the processed cylinder Type pipe, its outer diameter is 2mm, and the pipe wall thickness is 0.5mm;

[0071] 3) Pipe reinforcement and toughening:

[0072] First place the cylindrical pipe in a constant temperature oven at 60°C for 10 hours to promote the orderly formation of the crystal nucleus of the original structure of the material to strengthen and t...

Embodiment 2

[0084] A preparation method for a fully degradable vascular stent for treatment of vascular diseases, comprising the following steps:

[0085] 1) Raw material preparation:

[0086] Put polylactic acid and polylactic acid-trimethylene carbonate copolymer into a twin-screw extruder at a mass ratio of 70:30 for blending and granulation to obtain raw material B; the blending and granulation temperature of the twin-screw extruder is 180℃, the speed is 20rpm;

[0087] Wherein, the number average molar molecular weight of polylactic acid is 400,000, and the number average molar molecular weight of polylactic acid-trimethylene carbonate copolymer is 50,000;

[0088] 2) Processing into pipes:

[0089] Put the raw material B in a plastic extruder, and heat the raw material to a molten state in the plastic extruder. When the internal temperature drops to room temperature, it is processed into a cylindrical pipe; the processed cylindrical pipe has an outer diameter of 2.5mm and a wall ...

Embodiment 3

[0103] A preparation method for a fully degradable vascular stent for treatment of vascular diseases, comprising the following steps:

[0104] 1) Raw material preparation:

[0105] Take polylactic acid as raw material A, and the number average molar molecular weight of polylactic acid is 100,000;

[0106] 2) Processing into pipes:

[0107] Raw material A and polylactic acid-trimethylene carbonate copolymer are respectively placed in two extrusion heads in the extruder, and these two kinds of materials are heated to molten state in these two extrusion heads respectively, its The heating temperature is 180°C; the extruded pipe has two layers, the material of the inner layer is polylactic acid, and the material of the outer layer is polylactic acid-trimethylene carbonate copolymer; finally, it is naturally cooled until the internal temperature of the material drops to room temperature. That is, it is processed into a cylindrical pipe; the processed cylindrical pipe has an outer...

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Abstract

The invention provides a full-degradable vascular stent for vascular disease treatment. The full-degradable vascular stent is consisted of a stent body which is shaped like a circular tube and coating covering the stent body; the surface of the stent body is of a hollow-out reticulate structure engraved by laser; image marking pieces are respectively arranged at two ends of the stent body, image marking holes are arranged in the image marking pieces, and imaging objects are arranged in the image marking holes. The production method of the full-degradable vascular stent includes the steps of 1), preparing raw materials; 2), processing the raw materials into tubular products; 3), strengthening and toughing the tubular products; 4), preparing the stent body; 5), pressing the imaging objects into the image marking holes; 6), producing the drug coating and top controlled-releasing layers. The stent body is produced by adopting full-degradable material, so that the stent body can be gradually and fully absorbed by a basal body after implantation, and the problem about long-term medication of patients is solved; the imaging objects are arranged at two ends of the stent body, so that tracing role of the imaging objects can be well played during interventional operation; 3), the production method is simple in production, low in production cost, and the vascular stent produced is stable in performance.

Description

technical field [0001] The invention belongs to the technical field of three types of medical devices, and in particular relates to a fully degradable vascular stent for treating vascular diseases and a preparation method thereof. Background technique [0002] Since the world's first successful coronary intervention (PCI) in 1977, percutaneous coronary intervention has achieved rapid development, laying a solid foundation for the treatment of human coronary heart disease. [0003] In the technical field of stent treatment of vascular diseases, three generations of technology have been experienced. The initial technical product is a simple bare metal stent system, which uses a stent system made of inert metal to implant into blood vessels to achieve the purpose of treatment, but its technical defects are irreplaceable. The result to be avoided is that the restenosis rate of blood vessels after implantation is relatively high. The second-generation technology is improved on th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/16A61L31/18A61L31/06A61L31/10
CPCA61L31/06A61L31/10A61L31/148A61L31/16A61L31/18A61L2300/216A61L2300/602A61L2300/606A61L2420/08C08L67/04
Inventor 王亮李文龙陈彦良王明利高户生李守宗
Owner 乐普(深圳)国际发展中心有限公司
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