Preparation method of glycyrrhetinic acid transdermal agent

A technology of glycyrrhetinic acid and transdermal agents, which is applied in the field of preparation of glycyrrhetinic acid transdermal agents, can solve the problems of inconvenient clinical administration and limited utilization of liquid preparations, so as to improve the body's immunity, relieve local symptoms, and achieve quick results Effect

Inactive Publication Date: 2016-10-19
TIANJIN PHARMACN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is used as a topical preparation, it is often limited due to the inconvenience of clinical administration of liquid preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A glycyrrhetinic acid transdermal agent mainly contains glycyrrhetinic acid, and the encapsulation rate is 86.79±1.68%.

[0029] The preparation method of the above-mentioned glycyrrhetinic acid transdermal agent, the specific preparation steps are as follows:

[0030] (1) Superfine glycyrrhetinic acid and pass through a 200-mesh sieve;

[0031] (2) Weigh 25g of glycyrrhetinic acid as raw material;

[0032] (3) Add glycyrrhetinic acid to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;

[0033] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;

[0034] (5) Dissolve 1 g of chitosan in 32 mL of 1% glacial acetic acid solution, stir and dissolve the chitosan glacial acetic acid solution, where the stirring temperature is 45-55°C, and the heating method is steam heating;

[0035] (6) Dissolve 32 mL of traditional Chinese medicine extract A in step (5) c...

Embodiment 2

[0044] A glycyrrhetinic acid transdermal agent mainly contains glycyrrhetinic acid, and the encapsulation rate is 84.89±1.79%.

[0045] The preparation method of the above-mentioned glycyrrhetinic acid transdermal agent, the specific preparation steps are as follows:

[0046] (1) Superfine glycyrrhetinic acid and pass through a 300 mesh sieve;

[0047] (2) Weigh 30g of glycyrrhetinic acid as raw material;

[0048] (3) Add glycyrrhetinic acid to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;

[0049] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;

[0050] (5) Dissolve 7.5 g of chitosan in 160 mL of 2% glacial acetic acid, stir to dissolve the chitosan glacial acetic acid solution, the stirring temperature is 45, and the heating method is steam heating at °C.

[0051] (6) Dissolve 160 mL of Chinese medicine extract A in step (5) Chitooligosaccharide gla...

Embodiment 3

[0060] A glycyrrhetinic acid transdermal agent mainly contains glycyrrhetinic acid, and the encapsulation rate is 81.89±1.33%.

[0061] The preparation method of the above-mentioned glycyrrhetinic acid transdermal agent, the specific preparation steps are as follows:

[0062] (1) Superfine glycyrrhetinic acid and pass through a 100-mesh sieve;

[0063] (2) Weigh 28g of glycyrrhetinic acid as raw material;

[0064] (3) Add glycyrrhetinic acid to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;

[0065] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;

[0066] (5) Dissolve 1.8 g of chitosan in 32 mL of 3% glacial acetic acid, and stir to dissolve the chitosan glacial acetic acid solution. The stirring temperature is 55, and the heating method is steam heating at °C.

[0067] (6) Dissolve 64 mL of Chinese medicine extract A in step (5) Chitooligosaccharide g...

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Abstract

A preparation method of a glycyrrhetinic acid transdermal agent comprises the following steps: (1) dissolving glycyrrhetinic acid in anhydrous ethanol and distilled water; (2) heating to prepare a chitosan acetic acid solution; (3) mixing the traditional Chinese medicine with the chitosan acetic acid solution; (4) adding the mixture to an emulsification system for emulsification; (5) conducting a cross-linking reaction on the emulsion products; (6) treating the crosslinking reaction products by washing, precipitation, centrifugation and drying to obtain a transdermal drug containing the traditional Chinese medicine. The preparation method is simple, and suitable for large-scale industrial production.

Description

Technical field [0001] The invention relates to a preparation method of a transdermal agent, in particular to a preparation method of a glycyrrhetinic acid transdermal agent. Background technique [0002] Licorice is a perennial herb, belonging to the legume genus Glycyrrhiza. It has the effects of replenishing qi and invigorating the spleen, clearing away heat and detoxification, relieving pain and reconciling various medicines. Glycyrrhetinic acid is the main active ingredient of licorice, which has obvious anti-inflammatory, antibacterial, antiviral, liver cell protection and immune regulation and other pharmacological activities. It has good effects on local inflammations such as phlebitis, and can also be used to treat chronic hepatitis and liver cancer, but its oral and intramuscular administration effects are poor. [0003] The transdermal agent is a spatial network water-filled cross-linked structure formed by mixing hydrophilic polymer materials, moisturizers, cross-linki...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/56A61K47/36A61P29/00A61P31/04A61P31/12A61P1/16A61P37/02A61P9/14A61P35/00A61K31/722
Inventor 田东奎何磊
Owner TIANJIN PHARMACN MEDICAL TECH
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