Method for screening early-stage lung tumor in assisting mode through bronchoalveolar lavage fluid
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A technology for bronchoalveolar lavage fluid and lungs, which is applied in the field of medical testing, can solve the problems of high cost, high cost and trauma, and achieve the effect of accurate screening and low cost.
Inactive Publication Date: 2016-10-12
SHANTOU CENT HOSPITAL
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[0006] In recent years, medical thoracoscopy has been carried out more and more. Although its diagnostic efficiency is relatively high, many primary hospitals currently do not have this technology. Compared with routine examinations, the examination costs are high and traumatic. It is not suitable for pat
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Embodiment 1
[0042] like figure 1 As shown, this method of using alveolar lavage fluid to assist in screening early lung tumors includes the following steps:
[0043] (1) Use a fiberoptic bronchoscope to extend into the patient's lungs, and perfuse 37°C sterilized saline into the patient's lungs through the fiberoptic bronchoscope;
[0044] (2) Allow normal saline to stay in the patient's lungs for 3 to 5 minutes;
[0045] (3) By applying negative pressure on the outer end of the fiberoptic bronchoscope for negative pressure suction, the physiological saline injected into the patient's lungs is drawn out to form alveolar lavage fluid;
[0046] (4) Filter the alveolar lavage fluid with double-layer sterile gauze to remove the mucus in the alveolar lavage fluid;
[0047] (5) Treat the alveolar lavage fluid with an anticoagulant containing edetic acid;
[0048] (6) At room temperature, use a centrifuge at a speed of 1500r / min to centrifuge the alveolar lavage fluid for 10 minutes to furthe...
Embodiment 2
[0056] On the basis of Example 1, in step (10), the concentration P of M2-PK is also compared with the metabolic level of carcinoembryonic antigen CEA, and the normal range value of the metabolic level of carcinoembryonic antigen CEA is <10ug / L, if The concentration P of M2-PK is greater than 10ug / L, and the specific comparison method adopts the following steps:
[0057] (10-1) Use Pearson correlation analysis to analyze the correlation between the concentration P of M2-PK and the metabolic level of carcinoembryonic antigen CEA;
[0058] (10-2) Calculate the sensitivity, specificity, positive predictive value, negative predictive value and correct rate of M2-PK and carcinoembryonic antigen CEA respectively, and conduct comprehensive index evaluation, so as to judge whether the patient has early lung tumor auxiliary basis.
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Abstract
The invention relates to a method for screening early-stage lung tumor in an assisting mode through bronchoalveolar lavage fluid. Prior-art constraints of conventional lung outside sampling specimens and operation sampling lung specimens are broken through, normal saline is poured into the lung of a patient through a fiber bronchoscope and drawn out to form the bronchoalveolar lavage fluid, M2-PK monoclonal antibodies and second M2-PK antibodies are added, and the concentration of M2-PK in the bronchoalveolar lavage fluid is measured with the enzyme-linked immunosorbent assay method and compared with a critical value 18.68 U/ml; as the fiber bronchoscope can go deep into the lung of the patient, the bronchoalveolar lavage fluid is formed in the mode that alveolus pulmonis of the patient is directly washed and comprises alveolus pulmonis secreta, the lesion characteristics of the lung of the patient can be most reflected, the bronchoalveolar lavage fluid serves as an assistant judgment basis of the early-stage lung tumor, screening of the early-stage lung tumor is more accurate, and in addition, operation is not required, trauma is not generated, the method is safer and more reliable, and cost is also low.
Description
technical field [0001] The invention relates to a medical detection method, in particular to a method for assisting screening of early lung tumors by using alveolar lavage fluid. Background technique [0002] The large group of smokers and laborers who work in harsh air environment for a long time are mostly suspicious objects of lung tumors. However, the diagnosis of lung tumors is difficult at present. If patients are not diagnosed and treated in time, they will continue to deteriorate , and even life-threatening serious consequences. [0003] At present, various methods for early lung tumor screening have considerable limitations. [0004] For example, although cytological examination of pleural effusion exfoliation is the simplest and most specific examination method, its positive rate is low, and many cases with cytological examination of pleural effusion are often misjudged as suspicious for malignancy. [0005] Another example is that the positive rate of percutaneo...
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