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Anti-HIV pharmaceutical composition and preparation method thereof

A HIV/combination technology, applied in the field of anti-HIV pharmaceutical composition and its preparation, can solve the problems of obvious toxic and side effects, easy relapse of disease, inability to completely eliminate HIV, etc.

Inactive Publication Date: 2016-10-12
桂林淮安天然保健品开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this therapy cannot completely eliminate HIV. Once the drug is stopped, the disease is likely to recur, and the immune function will be reduced again.
In addition, the toxic and side effects of HAART therapy are obvious, such as hyperlactic acidemia, liver toxicity, hyperglycemia, abnormal fat distribution, rash, increased bleeding in hemophiliac patients, hyperlipidemia, osteoporosis, etc., which are prone to drug resistance sexual, and expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Recipe: 0.1 parts of bitter gourd, 2 parts of Ganoderma lucidum, 0.5 parts of black fungus and 5 parts of Luo Han Guo.

[0031] Preparation:

[0032] 1) Grind bitter gourd, ganoderma lucidum and black fungus in the formula, extract with 90v% ethanol as a solvent, the amount of ethanol is 8 times the weight of the mixed powder, reflux for 1 hour, filter the extract, and take the filter residue for later use;

[0033] 2) adding water to extract the filter residue in step 1), the amount of water added is 8 times the weight of the filter residue, reflux extraction for 1 hour, filtering the extract, and taking the filtrate for later use;

[0034] 3) Grinding the Luo Han Guo, extracting with 90v% ethanol as a solvent, the amount of ethanol is 8 times the weight of the Luo Han Guo powder, refluxing and extracting for 1 hour, filtering the extract, and taking the filter residue for later use;

[0035] 4) Extract the filter residue in step 3) with water, the amount of water add...

Embodiment 2

[0040] Recipe: 0.5 parts of bitter gourd, 4 parts of Ganoderma lucidum, 1 part of black fungus and 8 parts of Luo Han Guo.

[0041] Preparation:

[0042] 1) Grind bitter melon, ganoderma lucidum and black fungus in the formula, extract with 95v% ethanol as a solvent, the amount of ethanol is 10 times the weight of the mixed powder, reflux extraction 3 times, 3 hours each time, combine the extracts, filter, Take the filter residue for later use;

[0043] 2) Extract the filter residue in step 1) with water, the amount of water added is 10 times the weight of the filter residue, reflux extraction 3 times, 3 hours each time, combine the extracts, filter, and take the filtrate for later use;

[0044] 3) Grinding Luo Han Guo, extracting with 95v% ethanol as a solvent, the amount of ethanol is 10 times of the weight of Luo Han Guo powder, refluxing and extracting 3 times, 3 hours each time, combining the extracts, filtering, and taking the filter residue for later use;

[0045] 4) ...

Embodiment 3

[0050] Recipe: 0.2 parts of bitter gourd, 2.5 parts of Ganoderma lucidum, 0.6 parts of black fungus and 8 parts of Luo Han Guo.

[0051] Preparation:

[0052] 1) Grind bitter melon, ganoderma lucidum and black fungus in the formula, extract with 90v% ethanol as a solvent, the amount of ethanol is 9 times the weight of the mixed powder, reflux extraction twice, each time for 2h, combine the extracts, filter, Take the filter residue for later use;

[0053] 2) adding water to extract the filter residue in step 1), the amount of water added is 9 times the weight of the filter residue, reflux extraction 2 times, 2 hours each time, combining the extracts, filtering, and taking the filtrate for later use;

[0054] 3) Grinding Luo Han Guo, extracting with 95v% ethanol as a solvent, the amount of ethanol is 9 times the weight of Luo Han Guo powder, refluxing extraction twice, each time 2h, combining the extracts, filtering, and taking the filter residue for later use;

[0055] 4) add...

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PUM

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Abstract

The invention discloses an anti-HIV (human immunodeficiency virus) pharmaceutical composition and a preparation method thereof. The medicament comprises the following components by weight: 0.1-0.5 part of momordica charantia, 2-4 parts of Ganoderma lucidum, 0.5-1 part of black fungus, and 5-8 parts of Momordica grosvenori. The preparation method consists of: 1) firstly extracting momordica charantia, Ganoderma lucidum and black fungus with ethanol, then extracting the filter residue with water, and taking the filtrate for standby use; 2) extracting Momordica grosvenori firstly with ethanol, then adding water into the filter residue to perform extraction, and taking the filtrate for standby use; 3) passing the filtrate obtained in step 2) through a membrane filtration device with a molecular weight cutoff of 1000 Dalton, and collecting the effluent; 4) passing the filtrate obtained in step 1) through a membrane filtration device with a molecular weight cutoff of 15000 Dalton, and collecting the concentrated liquid; and 5) mixing the effluent with the concentrated liquid evenly, and carrying out concentration and drying, thus obtaining the product. The medicament provided by the invention can block HIV from entering target cells at multi-target points so as to achieve a synergistic anti HIV effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an anti-HIV pharmaceutical composition and a preparation method thereof. Background technique [0002] AIDS, Acquired Immunodeficiency Syndrome (AIDS), is a chronic infectious disease caused by Human Immunodeficiency Virus (HIV) infection. Under the direct or indirect effect of human immunodeficiency virus, T cell immunodeficiency and other immune cells are damaged to varying degrees, which promotes various serious opportunistic infections and tumors, leading to death. Specifically, HIV attacks the immune system of the human body and destroys the immune balance, thereby infecting the human body with other diseases, leading to various co-infections and death. After HIV virus infects host cells, it reproduces in large numbers and destroys CD 4 +T lymphocytes reduce the body's resistance, leading to various complex infections and death. Common infections such as: hepa...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61P31/18
CPCA61K36/42A61K36/07A61K36/074A61K2236/333A61K2300/00
Inventor 苏华
Owner 桂林淮安天然保健品开发有限公司
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