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Application of c-Kit serving as drug addiction treatment target

A 1.c-kit, 2.c-kit technology, applied in the field of medicine, to achieve the effect of treating substance addiction, good treatment effect and preventing relapse

Active Publication Date: 2016-09-28
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, whether c-Kit plays an important role in addiction and whether it can be used as a target for detoxification drugs has not been reported

Method used

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  • Application of c-Kit serving as drug addiction treatment target
  • Application of c-Kit serving as drug addiction treatment target
  • Application of c-Kit serving as drug addiction treatment target

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] [Example 1] Effect of imatinib on the expression of morphine sensitization in rats

[0019] In this example, imatinib was selected as the anti-morphine-addicted high-incidence drug, and by establishing a morphine-sensitized rat model, the effect of c-Kit inhibitor imatinib on the high-incidence spontaneous activity induced by morphine in rats was explored. To improve the effect, the aim is to select a drug target for the high incidence of spontaneous activity caused by antipsychoactive substances with definite curative effect and low toxicity.

[0020] Materials and Methods

[0021] Drugs and reagents Morphine (Qinghai Pharmaceutical Factory); Imatinib (Novartis PharmaSteinAG);

[0022] Animals SPF grade SD male rats, weighing 220-250g. Provided by the Hubei Laboratory Animal Research Center, the animal certificate number is NO.42000600012344, and the production license number is SCXK (Hubei) 2015-2018. Rat feed was purchased from the Experimental Animal Center of Wu...

Embodiment 2

[0030] [Example 2] Nucleus localization of the nucleus accumbens. Administration of imatinib inhibits the craving for morphine addiction in rats

[0031] From the results of Example 1, it can be seen that imatinib can be used as an anti-morphine addiction drug, and it is an inhibitor of c-Kit. By establishing a morphine conditional place preference (conditioned place preference, CPP) model, study imatinib Neil localized the effect of microinjection into the nucleus accumbens of the nucleus accumbens on psychological craving after withdrawal from morphine dependence, and at the same time observed the activity changes of c-Kit, which is heavily expressed in brain regions related to addictive drug action (Katafuchi, 2000). The aim is to determine its role as a drug target in the screening of a drug addiction treatment drug with definite curative effect and low toxicity.

[0032] Materials and Methods

[0033] Drugs and reagents Morphine (Qinghai Pharmaceutical Factory); Imatinib...

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PUM

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Abstract

The invention discloses new application of c-Kit, and provides application of the c-Kit serving as a drug target in screening of drugs for treating drug addiction and application of the c-Kit in screening of drugs for treating substance dependence addiction psychological craving and excitability of addiction drugs. A classical rat sensitization and conditioned place preference animal model for evaluating addiction is adopted for observing influences of an inhibitor imatinib of the c-Kit on renewed behaviors after formation and withdrawal of rat sensitization behavior expression and conditioned place preferences respectively, the inhibiting effect of imatinib on morphine addiction and an anti-relapse effect after withdrawal of morphine addiction is achieved are evaluated, and application of an acting target c-Kit receptor serving as the drug treatment target of drug addiction is determined. The c-Kit is good in effect and is expected to fundamentally treat drug addiction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of c-Kit as a drug target in screening drugs for treating drug addiction. Background technique [0002] Drug abuse or addiction has become a worldwide medical and sociological problem. Drugs not only seriously endanger human health, but also bring a series of economic, social and political problems. According to the 2013 World Drug Report of the United Nations Office on Drugs and Crime, the international drug abuse population accounted for 0.3% to 0.9% of the total number of adults in the world in 2011, while the number of registered drug abusers in my country was 2.475 million. In recent years, the abuse of exogenous opioids (such as morphine and heroin) has become an increasingly serious social problem. It not only seriously destroys the physical and mental health of the abuser, but also brings disastrous consequences to the family and society. Be...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/48
CPCG01N33/48G01N33/68G01N33/6893G01N2333/435G01N2800/307
Inventor 李艳琴杨奇陈萍萍
Owner WUHAN UNIV
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