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Application of dendrobium officinale polysaccharides to preparation of antidepressant medicines and antidepressant healthcare products

A Dendrobium officinale polysaccharide, technology of Dendrobium officinale, applied in the field of medicine, to achieve good anti-depressant effect, widen the source, and high safety effect

Active Publication Date: 2016-09-28
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no related literature report that Dendrobium officinale has antidepressant effect

Method used

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  • Application of dendrobium officinale polysaccharides to preparation of antidepressant medicines and antidepressant healthcare products
  • Application of dendrobium officinale polysaccharides to preparation of antidepressant medicines and antidepressant healthcare products
  • Application of dendrobium officinale polysaccharides to preparation of antidepressant medicines and antidepressant healthcare products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Water Extraction and Alcohol Precipitation Method to Extract Dendrobium officinale Polysaccharide

[0031] 1.1 Cut Dendrobium candidum into 3mm long sections, weigh 100g of Dendrobium candidum, add 2L of water to decoct each time after washing, decoct three times, each time for two hours, to obtain Dendrobium candidum medicinal liquid; After the Dendrobium officinale medicinal liquid was filtered, the Dendrobium officinale medicinal liquid obtained by merging decoction for three times was concentrated under reduced pressure to obtain the extractum; after five times of precipitation with 95% ethanol, add 200ml of water to dissolve, add Sevage reagent (n-butanol: chloroform is 1:4) 100ml, deproteinized, and repeated the operation 3 times; finally added 95% ethanol for precipitation, and vacuum dried to obtain the polysaccharide of Dendrobium officinale, and the polysaccharide yield of Dendrobium officinale was 13.78%.

Embodiment 2

[0032] Embodiment 2 mouse forced swimming test

[0033] 2.1 Experimental animals Male ICR mice were purchased from the Experimental Animal Center of Fujian University of Traditional Chinese Medicine, weighing 22-26g, and the license number is SCXK (Fujian) 2010-0001; the animals were placed in cages of 320×180×160cm, with 8 mice per cage , the mice acclimatized to the environment for one week; during the whole experiment, the mice were given free access to water and food, the ambient temperature was 22±2°C, the relative humidity was 55±5%, and the light was 12 hours a day (7:00 am to 7:00 pm).

[0034]2.2 Drug preparation The positive drug fluoxetine hydrochloride was prepared into a 15mg / 10ml liquid medicine with 0.1% Tween-80 as a solvent; Dendrobium officinale polysaccharide was prepared into three doses of liquid medicines of 150mg / ml, 300mg / ml, and 600mg / ml.

[0035] 2.3 Animal grouping and administration method 40 mice were divided into 5 groups, 8 in each group, respect...

Embodiment 3

[0039] Embodiment 3 mouse tail suspension test

[0040] 3.1 Experimental animals Male ICR mice were purchased from the Experimental Animal Center of Fujian University of Traditional Chinese Medicine, weighing 22-26g, and the license number is SCXK (Fujian) 2010-0001; the animals were placed in cages of 320×180×160cm, 8 per cage , the mice acclimatized to the environment for one week; during the whole experiment, the mice were given free access to water and food, the ambient temperature was 22±2°C, the relative humidity was 55±5%, and the light was 12 hours a day (7:00 am to 7:00 pm).

[0041] 3.2 Drug preparation The positive drug fluoxetine hydrochloride was prepared into a 15mg / 10ml liquid medicine with 0.1% Tween-80 as a solvent; Dendrobium officinale polysaccharide was prepared into three doses of liquid medicines of 150mg / ml, 300mg / ml, and 600mg / ml.

[0042] 3.3 Animal grouping and administration method 40 mice were divided into 5 groups, 8 in each group, respectively mod...

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Abstract

The invention belongs to the technical field of medicines and provides application of dendrobium officinale polysaccharides to preparation of antidepressant medicines and antidepressant healthcare products. Dendrobium officinale is used as a natural medicine and food for a long time and high in safety when serving as a medicine and a healthcare product. The dendrobium officinale polysaccharides have an excellent antidepressant effect, thereby being used for pharmaceutical production or healthcare product production as antidepressant medicines and antidepressant healthcare products. Further, sources of the antidepressant natural medicines and antidepressant healthcare products are broadened.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of dendrobium officinale polysaccharide in the preparation of antidepressant medicine and antidepressant health products. Background technique [0002] Dendrobium officinale Kimura et Migo is a perennial herb of the genus Dendrobium orchidaceae. It mostly grows in humid, warm, half-shady and half-yang environments. It is distributed in Fujian, Guangxi, Yunnan and other places. It has the functions of nourishing stomach, promoting body fluid and nourishing yin Heat-clearing function. [0003] Depression is a kind of mental disease of mood disorder, which is persistent depression caused by external environment and psychological quality, accompanied by clinical symptoms such as loss of interest, loss of energy, slow movement, loss of appetite or weight. [0004] Since the 1950s, the advent of antidepressant drugs has replaced traditional electroconvulsive therapy a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P25/24A23L33/00A61K36/8984
CPCA23V2002/00A61K31/715A61K36/8984A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2200/322A23V2250/21
Inventor 易立涛方金镇刘青
Owner HUAQIAO UNIVERSITY
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