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Aminomethylbenzoic acid and injection composition and quality control method thereof

A technology of aminomethylbenzoic acid and injection, which is applied in the field of hemorrhage and can solve problems such as inability to block

Active Publication Date: 2016-09-07
HUNAN DONGTING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin

Method used

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  • Aminomethylbenzoic acid and injection composition and quality control method thereof
  • Aminomethylbenzoic acid and injection composition and quality control method thereof

Examples

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Embodiment Construction

[0081] The present invention can be further described by the following examples, however, the scope of the present invention is not limited to the following examples. Those skilled in the art can understand that various changes and modifications can be made in the present invention without departing from the spirit and scope of the present invention. The present invention provides general and / or specific descriptions of the materials and test methods used in the tests. While many of the materials and methods of manipulation which are employed for the purposes of the invention are well known in the art, the invention has been described here in as much detail as possible. The following examples further illustrate the invention without limiting it.

[0082] In the following examples, the pH adjuster used (ie, acid-base adjuster in the present invention), unless otherwise specified, is 1M sodium hydroxide solution or 1M hydrochloric acid solution. The various tests below are for...

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Abstract

The invention relates to an aminomethylbenzoic acid and injection composition and a quality control method thereof. Particularly, on one hand, the invention relates to a quality control method for an aminomethylbenzoic acid bulk drug or an aminomethylbenzoic acid injection. The method comprises the step of determining the contents of p-methyl benzoic acid and p-carboxyl benzyl chloride in a test sample by virtue of a high performance liquid chromatography. In another embodiment, the method further comprises the step of determining the content of aminomethylbenzoic acid in the test sample by virtue of the high performance liquid chromatography. On the other hand, the invention relates to aminomethylbenzoic acid as a pharmaceutical bulk drug and an injection including aminomethylbenzoic acid and injection water. Quality control on p-methyl benzoic acid and p-carboxyl benzyl chloride in the test sample is realized in a content determination manner by virtue of the high performance liquid chromatography. The method provided by the invention has excellent performances as shown in the specification.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a hemorrhage that can be used for hemorrhage caused by excessive primary fibrinolysis, including acute and chronic, localized or systemic hyperfibrinolytic hemorrhage, which is common in cancer, leukemia, Raw materials for obstetrical and gynecological accidents, severe hepatic hemorrhage, etc., and their injection pharmaceutical compositions, especially involving aminotoluic acid raw materials and injection pharmaceutical compositions containing aminotoluic acid. The present invention further relates to a method for quality control of the aminomethylbenzoic acid crude drug and aminomethylbenzoic acid injection composition. The method of the invention has excellent performance. Background technique [0002] Aminomethylbenzoic acid (Aminomethylbenzoic Acid), p-aminomethylbenzoic acid monohydrate, also known as anti-blood fibrinolytic aromatic acid, p-carboxybenzylamine, 4-(aminome...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06A61K9/08A61K31/195A61P7/04
CPCA61K9/0019A61K9/08A61K31/195G01N30/06G01N30/88
Inventor 侯奇伟朱姣刘勇
Owner HUNAN DONGTING PHARMA
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