Dimetridazole soluble powder and preparation method thereof

Abstract

The invention belongs to the technical field of veterinary chemical medicinal preparations, and particularly relates to a dimetridazole soluble powder and a preparation method thereof. The dimetridazole soluble powder is prepared from the following components in parts by weight: 18-22 parts of dimetridazole and 10-15 parts of hydrophilic carrier, and the balance of glucosum anhydricum or lactose anhydrous supplemented to 100 percent, wherein the hydrophilic carrier is one or more of PVP K30, poloxamer 188 and sodium lauryl sulfate. According to the dimetridazole soluble powder, the specific surface area of an insoluble medicine can be improved, and the wetting property can be increased, so that solubility of dimetridazole can be improved, the dissolving time is shortened, and the aim of clinical drinking water administration can be achieved. The dimetridazole has good bioavailability and good medicinal effect.

Description

technical field [0001] The invention belongs to the technical field of veterinary chemical drug preparations, and more specifically relates to a soluble powder of dimetridazole and a preparation method thereof. Background technique [0002] Dimenidazole is a broad-spectrum anti-anaerobic bacteria and antiprotozoal drug, which can effectively prevent and control poultry diseases such as histomoniasis in chickens, trichomoniasis in pigeons, treponema dysentery in swine, and trichomoniasis in bovines. Dimenidazole is an off-white or light yellow powder, which is difficult to dissolve in water. Dimenidazole for livestock and poultry currently on the market is basically a premix that is insoluble in water and can only be administered with mixing materials. However, the current administration method for large-scale poultry farming is mainly based on drinking water administration, so the clinical use of this product is greatly limited. Patents CN103432136A and CN103690940A both de...

AI Technical Summary

Problems solved by technology

Dimenidazole is off-white or slightly yellow powder, which is difficult to dissolve in water. Dimenidazole for livestock and poultry currently on the market is basically a premix that cannot be dissolved in water, and can only be mixed with ingredients for administration.

However, the current administration methods for large-scale poultry farming are mainly based on drinking water administration, so the clinical use of this product is greatly restricted

Both patents CN103432136A and CN103690940A describe the compound Dimenidazole product using anhydrous glucose as a carrier, but the simple mixing process of anhydrous glucose and Dimenidazole cannot increase the solubility of Dimenidazole

Patent CN102988363A describes a product in which Dimenidazole and β-cyclodextrin are co-ground through a 100-mesh sieve, and then mixed with raw and auxiliary materials such as polyvinylpyrrolidone and anhydrous glucose. The solubility of β-cyclodextrin in this prescription is low (1.8g / 100ml), easy to precipitate crystals from water, simple co-grinding of Dimenidazole and β-cyclodextrin through a 100-mesh sieve can not effectively improve the solubility of Dimenidazole, so it does not solve the problem of Dimenidazole water soluble problem

[0003] Dimenidazole is a chemical drug that is difficult to dissolve in water. The current marketed veterinary Dimenidazole product is a premix used for mixing materials and cannot be administered through drinking water.

The original Dimenidazole premix product can only be used as a mixing material and cannot be administered in drinking water; some original Dimenidazole and water-soluble anhydrous glucose simply mixed products need to dissolve 0.2g of the active ingredient in 1L of water More than 3 hours, can not meet the needs of large-scale breeding drinking water administration