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Preparation method of moso bamboo cellulose based nano oral drug carrier

A cellulose-based, cellulose-based technology that is applied in pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as not seen, reduce toxic side effects, and improve medication compliance Sex, the effect of expanding the range of raw materials

Inactive Publication Date: 2016-08-31
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, there has been no related technology for the preparation of bamboo cellulose-based nano oral drug carriers using moso bamboo cellulose as the source of drug carriers.

Method used

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  • Preparation method of moso bamboo cellulose based nano oral drug carrier
  • Preparation method of moso bamboo cellulose based nano oral drug carrier
  • Preparation method of moso bamboo cellulose based nano oral drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Preparation of Moso bamboo cellulose-based nano-oral drug carrier

[0038] 1) After pulverizing the moso bamboo pulp board, filter it through a 100-mesh sieve to obtain moso bamboo pulp powder with a particle size less than or equal to 0.15 mm.

[0039] 2) Place the moso bamboo pulp powder obtained in step 1) at 45° C. and react in 60 wt % sulfuric acid solution for 180 min. The mass ratio of moso bamboo pulp powder to sulfuric acid solution is 1:15, and distilled water at room temperature with 10 times the volume of the above sulfuric acid solution is used Terminate the reaction, centrifuge and wash the residual acid with distilled water, and put the reacted mixture into a dialysis bag with a molecular weight cut-off of 120 kDa at room temperature, place it in distilled water and dialyze to neutrality, and freeze-dry to obtain the nanocrystalline cellulose of Moso bamboo.

[0040] 3) the bamboo nano-microcrystalline cellulose obtained in step 2) is dissolved in sodi...

Embodiment 2

[0046] 1. Preparation of Moso bamboo cellulose-based nano-oral drug carrier

[0047] 1) with embodiment 1.

[0048] 2) Place the moso bamboo pulp powder obtained in step 1) at 55° C. and react in 65 wt% sulfuric acid solution for 90 minutes. The mass ratio of moso bamboo pulp powder to sulfuric acid solution is 1:10, and distilled water at room temperature with 10 times the volume of the above sulfuric acid solution is used. Terminate the reaction, centrifuge and wash the residual acid with distilled water, and put the reacted mixture into a dialysis bag with a molecular weight cut-off of 130 kDa at room temperature, dialyze in distilled water until neutral, and freeze-dry to obtain Moso bamboo nanocrystalline cellulose.

[0049] 3) the bamboo nano-microcrystalline cellulose obtained in step 2) is dissolved in sodium hydroxide / urea solution, the mass fraction ratio of sodium hydroxide / urea solution is 6:4, and the moso bamboo nano-microcrystalline cellulose and sodium hydroxid...

Embodiment 3

[0055] 1. Preparation of Moso bamboo cellulose-based nano-oral drug carrier

[0056] 1) with embodiment 1.

[0057] 2) Place the moso bamboo pulp powder obtained in step 1) at 35°C and react in 55wt% sulfuric acid solution for 270min, the mass ratio of moso bamboo pulp powder to sulfuric acid solution is 1:20, and use room temperature distilled water with 10 times the volume of the above sulfuric acid solution Terminate the reaction, wash the residual acid by centrifugation with distilled water, and put the reacted mixture into a dialysis bag with a molecular weight cut-off of 140 kDa at room temperature, place it in distilled water and dialyze to neutrality, freeze-dry to obtain Moso bamboo nanocrystalline cellulose.

[0058] 3) the bamboo nano-microcrystalline cellulose obtained in step 2) is dissolved in sodium hydroxide / urea solution, the mass fraction ratio of sodium hydroxide / urea solution is 6:4, and the moso bamboo nano-microcrystalline cellulose and sodium hydroxide ...

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Abstract

The invention discloses a preparation method of a moso bamboo cellulose based nano oral drug carrier. The preparation method is characterized by including: using moso bamboo cellulose as a basic raw material; subjecting a moso bamboo pulp plate to acidolysis through sulfuric acid to obtain moso bamboo nano microcrystalline cellulose; chemically modifying the moso bamboo nano microcrystalline cellulose to obtain the moso bamboo cellulose based nano oral drug carrier. By using the drug carrier, medication compliance can be improved, toxic and side effect of conventional carriers can be reduced, and drug administration efficiency can be improved. In addition, a brand-new path is opened up for recycling moso bamboo to prepare high-added-value nano new materials.

Description

technical field [0001] The invention belongs to the field of organic polymer materials, and relates to a preparation method of a nanometer oral drug carrier, in particular to a preparation method of a moso bamboo cellulose-based nanometer oral drug carrier. Background technique [0002] At present, conventional pharmaceutical preparations used in clinical practice, such as solutions, suspensions, and emulsions, have many limitations, such as first-pass effect, low drug utilization, and toxic and side effects, which can no longer meet the needs of clinical medication. Nano-drug carriers are expected to make a breakthrough in this regard. [0003] Compared with traditional drug carriers, nano-drug carriers have many specific advantages, as follows: (1) Nano-drug carriers can enter capillaries through blood circulation, and can also enter lesions through the gap between endothelial cells and be pinocytized by cells. (2) Nano-carriers have small particle size and high specific ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K31/192A61K31/18C08B15/00
CPCA61K47/38A61K31/18A61K31/192C08B15/00
Inventor 张勇张潇姚菊明麻景淇陈可忻
Owner ZHEJIANG SCI-TECH UNIV
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