Biological protective covering

Abstract

The invention discloses a biological protective covering and a preparation method thereof. The biological protective covering is made of a substrate namely animal intestinal membranes, which have been crosslinked and fixed by a non-aldehyde fixing agent and subjected to an antigen removal treatment. An active modification layer, which contains fibronectin, laminin, or vitronectin that can adhere to cells, or an antibacterial sustained-release layer containing antibacterial drugs is arranged on the surface of the substrate. The biological protective covering is made of thin and tough animal intestinal membranes, and is light, soft, and user-friendly. The intestinal membranes are semi-permeable, gas and steam can penetrate the intestinal membranes, but bacteria cannot go through the intestinal membranes. Moreover, the intestinal membranes have been subjected to a multi-aspect antigen removal treatment to effectively remove the immunogenicity, the surface is subjected to active modification, the surface can aggregate epithelial cells and fibroblast to promote wound healing; the antibacterial drugs can be sustained-released, the anti-infection effect is enhanced, and the using performance and protective effect are better than those of dressing or protective covering made of pig skin.

Description

technical field [0001] The invention relates to a medical product used for wound protection in wound treatment, which belongs to the second-class medical device. Background technique [0002] Since the human body has a complete repair mechanism for wounds, many small and medium wounds can heal by themselves only by protecting the wound surface from infection. The primary measure of general trauma treatment is to clean and disinfect the wound surface, and protect the wound surface with a wound dressing to prevent subsequent infection. Therefore, in recent years, the development of wound-protecting dressings has been rapid, and various wound-protecting films have been launched from time to time. But most of them are synthetic material films, such as silicone rubber film, polyurethane film, nylon film, polyester film, polyethylene film, polypropylene film, etc. After a period of application, people gradually found that the tissue compatibility of synthetic materials is not goo...

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Problems solved by technology

But most of them are synthetic material films, such as silicone rubber film, polyurethane film, nylon film, polyester film, polyethylene film, polypropylene film, etc. After a period of application, people gradually found that the tissue compatibility of synthetic materials is not good, The treatment effect is unsatisfactory. Some people try to use natural biomaterials such as collagen to make wound protection membranes, but the mechanical properties of collagen are poor, and synthetic membranes must be used to strengthen them. Although this composite membrane of collagen synthetic materials can improve its tissue compatibility, But the thickness increases, the softness becomes worse, the air permeability is not good, and the performance is not good.

Some people also use chitosan and chitosan-collagen complex to make wound protection membranes, but the mechanical strength is poor, the toughness and softness are not good enough, and they have not been widely used. In recent years, some people have used pigskin as wound protection membranes, but only with the traditional Advanced glutaraldehyde fixation and chrome tanning treatment technology, no special antigen removal treatment, residual toxicity of aldehyde, weak rejection reaction if antigen removal is not complete, poor softness in dry state, enlarged pores after drying, and bacterial barrier properties Poor, use performance and treatment effect are not ideal, affecting its popularization and application

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