Biological wound protecting film and preparation method thereof

Abstract

The invention discloses a biological wound protecting film and a preparation method thereof. The biological wound protecting film is formed by using animal goldbeater's skin subjected to cross-linking fixation by non-aldehyde fixing agents and antigen extraction treatment as a substrate. An active modification layer containing cell-attachable fibronectin, laminin or vitronectin or an antibacterial sustained release layer containing antibacterial medicine is arranged on the surface of the substrate. The biological wound protecting film is prepared from the thin and tough animal goldbeater's skin, so that the weight is light; softness is realized; and the use is convenient. The goldbeater's skin belongs to a semipermeable membrane, has small and dense micropores, good air permeability, good steam permeability and germ impermeability; through all-round antigen extraction treatment, the immunogenicity is effectively removed; through surface active modification, epithelial cells and fibroblasts can be enrolled to promote wound healing; or the antibacterial medicine can be slowly released, and the anti-infection effect is enhanced; and the use performance and the wound protection effects are better than those of dressing or a protection film made of pigskin.

Description

technical field [0001] The invention relates to a medical article for protecting wound surface in wound treatment, which belongs to the second-class medical device. Background technique [0002] Because the human body has a perfect repair mechanism for wounds, many small and medium wounds can heal by themselves only by protecting the wound surface so that it is not infected. The primary measures for general trauma treatment are to clean and disinfect the wound surface, and use wound dressings to protect the wound surface to prevent subsequent infection. Therefore, in recent years, the development of wound care dressings has been rapid, and various wound protection films have been launched from time to time. But most of them are synthetic material films, such as silicone rubber film, polyurethane film, nylon film, polyester film, polyethylene film, polypropylene film, etc. After a period of application, people gradually found that the histocompatibility of synthetic material...

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Problems solved by technology

But most of them are synthetic material films, such as silicone rubber film, polyurethane film, nylon film, polyester film, polyethylene film, polypropylene film, etc. After a period of application, people gradually found that the tissue compatibility of synthetic materials is not good, The treatment effect is unsatisfactory. Some people try to use natural biomaterials such as collagen to make wound protection membranes, but the mechanical properties of collagen are poor, and synthetic membranes must be used to strengthen them. Although this composite membrane of collagen synthetic materials can improve its tissue compatibility, But the thickness increases, the softness becomes worse, the air permeability is not good, and the performance is not good.

Some people also use chitosan and chitosan-collagen complex to make wound protection membranes, but the mechanical strength is poor, the toughness and softness are not good enough, and they have not been widely used. In recent years, some people have used pigskin as wound protection membranes, but only with the traditional Advanced glutaraldehyde fixation and chrome tanning treatment technology, no special antigen removal treatment, residual toxicity of aldehyde, weak rejection reaction if antigen removal is not complete, poor softness in dry state, enlarged pores after drying, and bacterial barrier properties Poor, use performance and treatment effect are not ideal, affecting its popularization and application

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