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Medicine for treating ulcer diseases and preparation method of medicine

A technology for ulcer disease and medicine, which is applied in the field of traditional Chinese medicine and its preparation, can solve the problems of delayed treatment, dark medicine color, and low content of active ingredients, and achieve the effects of improving production efficiency, light liquid color, and high compliance

Inactive Publication Date: 2016-08-24
陈光健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the content of active ingredients such as small molecular peptides and amino acids in the medicine for treating ulcer disease is low in the preparation of the Periplaneta americana extract extracted by the existing Periplaneta americana extract preparation method, so the curative effect is poor, and the obtained medicine has a darker color and luster. The stench is strong, and some patients have resistance during use, and even experience nausea, vomiting and other gastrointestinal discomforts, resulting in inability to continue treatment and delaying the condition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 The preparation of medicine of the present invention

[0032] Prescription: Periplaneta americana 100kg, medicinal glycerin 150kg, sodium benzoate 3kg, ethylparaben 0.25kg, propylparaben 0.25kg

[0033] Adding the volume fraction of 8 times the amount of medicinal material dry weight in the weighed 100kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, and carries out the first reflux, and the reflux time is 2.5 hours; The 75% ethanol of 6 times of the amount of the dry weight of the medicinal material was refluxed for the second time, and the reflux time was 2 hours; the 75% ethanol of the 6 times of the amount of the original medicinal material dry weight was continued to be added in the medicinal residues to reflux for the third time, and the reflux time was 2 hours. Hours; the reflux temperature is controlled at 70-80°C, and the extracts obtained by reflux three times are combined, filtered through a 100-mesh screen to obtain t...

Embodiment 2

[0035] Example 2 The preparation of medicine of the present invention

[0036] Prescription: Periplaneta americana 50kg, medicinal glycerin 75kg, sodium benzoate 1.5kg, ethylparaben 0.1kg, propylparaben 0.1kg

[0037] Adding the volume fraction of 8 times the amount of medicinal material dry weight in the weighed 50kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, and carries out the first reflux, and the reflux time is 2.5 hours; The 75% ethanol of 4 times the dry weight of the medicinal material is refluxed for the second time, and the reflux time is 2 hours; the reflux temperature is controlled at 70-80°C, the extract obtained by the second reflux is combined, and the 100-mesh sieve is filtered to obtain the ethanol extraction. The liquid is slowly added into the double-effect concentrator for concentration without foaming. The setting conditions of the double-effect concentrator are that the vacuum degree of the first effect is -0.02~-0.04Mpa...

Embodiment 3

[0039] Example 3 The preparation of medicine of the present invention

[0040] Prescription: Periplaneta americana 150kg, glycerin 225kg, sodium benzoate 4.5kg, ethylparaben 0.375kg, propylparaben 0.375kg

[0041] Adding the volume fraction of 8 times the amount of medicinal material dry weight in the weighed 150kg American cockroach body is after 8 hours of ethanol cold soaking of 75%, and carries out the first reflux, and the reflux time is 2.5 hours, and then the medicinal residues are carried out Reflux extraction 3 times, add 75% ethanol of 4 times the dry weight of the original medicinal material to the dregs each time for reflux extraction, the reflux time is 2 hours, the reflux temperature is controlled at 70-80°C, and the extracts obtained by reflux four times are combined , filter the 100-mesh sieve to obtain the ethanol extract slowly without foaming, and then add it to the double-effect concentrator for concentration. ℃; the second-effect vacuum degree is -0.0...

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PUM

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Abstract

The invention provides a medicine for treating ulcer diseases and a preparation method of the medicine. The medicine consists of the following components in parts by weight: 50-150 parts of periplaneta americana, 75-225 parts of medicinal glycerol, 1.5-4.5 parts of sodium benzoate, 0.1-0.4 parts of ethyl hydroxybenzoate and 0.1-0.4 parts of propyl hydroxybenzoate. The preparation method comprises the following steps: soaking, extracting, concentrating and degreasing. The total effective rate of the medicine disclosed by the invention on treating ulcerative colitis can achieve 97.62%, and the total effective rate on treating gastric ulcer can achieve 100%. The preparation method of the invention can reduce cost and improve production efficiency.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and its preparation, in particular to a medicine for treating ulcer disease and a preparation method thereof. Background technique [0002] Peptic ulcers mainly refer to chronic ulcers that occur in the stomach and duodenum, but can also occur in the lower esophagus, around the gastrojejunostomy, and in MECKEL's diverticulum containing ectopic gastric mucosa. A large number of studies have fully proved that Helicobacter pylori infection is the main cause of peptic ulcer. Its clinical manifestation is epigastric pain, often presents dull pain, dull pain, distending pain, burning pain. The pain of gastric ulcer usually occurs within 1 hour after a meal, and gradually relieves after 1 to 2 hours, and the above rhythm reappears until the next meal. Some patients may be asymptomatic, or have complications such as bleeding and perforation as the first symptom. Ulcer disease is a chronic co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P1/04A61P1/02
Inventor 陈光健
Owner 陈光健
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