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Preparation method and application of novel nano hydrogel

A nano-hydrogel, distilled water technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulations, inorganic active ingredients, etc., can solve the problems of immature application of nano-drug carriers, and achieve high yield, system stability, and affinity. water-enhancing effect

Inactive Publication Date: 2016-08-17
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the application of nano-drug carriers is still immature, and the biological safety of nano-materials needs further demonstration and research.

Method used

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  • Preparation method and application of novel nano hydrogel
  • Preparation method and application of novel nano hydrogel
  • Preparation method and application of novel nano hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A nano hydrogel is composed of the following components in parts by weight:

[0027]

[0028] (1) Dissolve 3 parts of alginic acid in 80 parts of distilled water, add 0.2 parts of sodium periodate, react in the dark at 40°C for 6 hours, add 10 parts of ethylene glycol and 3 parts of NaCl and stir for 15 minutes to terminate the reaction, and use 10 parts of absolute ethanol Precipitation, washing, suction filtration, vacuum drying at 45°C, dialyzing the obtained solid powder in distilled water, changing the water continuously during the period, taking the dialysate and adding it to AgNO 3 solution, ensure that no precipitation occurs, and then freeze-dry the dialysate;

[0029] (2) At room temperature, add 4 parts of sucrose and 3 parts of cellulose into 4 parts of sodium hydroxide solution with a mass fraction of 20%, stir evenly, carry out alkalization treatment, add 15 parts of isopropanol, 0.8 part of tetramethylhydrogen Ammonium oxide, 16 parts of propylene oxi...

Embodiment 2

[0032] A nano hydrogel is composed of the following components in parts by weight:

[0033]

[0034] (1) Dissolve 3 parts of sodium alginate in 80 parts of distilled water, add 0.4 parts of potassium permanganate, react in the dark at 40°C for 6 hours, add 6 parts of ethylene glycol and 2 parts of NaCl and stir for 15 minutes to terminate the reaction, and use 12 parts of anhydrous Ethanol will precipitate, wash, filter, and vacuum dry at 45°C. The obtained solid powder is dialyzed in distilled water, and the water is changed continuously during the period. 3 solution, ensure that no precipitation occurs, and then freeze-dry the dialysate;

[0035] (2) At room temperature, add 3 parts of β-cyclodextrin and 5 parts of cellulose into 3 parts of sodium hydroxide solution with a mass fraction of 20%, stir evenly, carry out alkalization treatment, add 18 parts of isopropanol, 0.6 parts of Tetramethylammonium hydroxide, 10 parts of propylene oxide, reacted at room temperature fo...

Embodiment 3

[0038] A nano hydrogel is composed of the following components in parts by weight:

[0039]

[0040]

[0041] (1) Dissolve 1 part of alginic acid in 80 parts of distilled water, add 0.3 parts of potassium permanganate, react at 40°C in the dark for 6 hours, add 3 parts of ethylene glycol and 1 part of NaCl and stir for 15 minutes to terminate the reaction, and use 15 parts of absolute ethanol Precipitation, washing, suction filtration, vacuum drying at 45°C, dialyzing the obtained solid powder in distilled water, changing the water continuously during the period, taking the dialysate and adding it to AgNO 3solution, ensure that no precipitation occurs, and then freeze-dry the dialysate;

[0042] (2) Add 4 parts of sodium hydroxide solution with a mass fraction of 20% to 2 parts of chitosan and 2 parts of β-cyclodextrin at room temperature, stir evenly, carry out alkalization treatment, add 12 parts of isopropanol, 0.6 part of Tetramethylammonium hydroxide, 20 parts of p...

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Abstract

The invention relates to nano hydrogel and a preparation method thereof. The nano hydrogel comprises 1-5 parts of a reaction matrix, 1-5 parts of a saccharide compound, 3-20 parts of an alcohol compound, 0.1-0.5 part of an oxidizing agent, 1-5 parts of an alkaline solution, 1-5 parts of a pore-foaming agent, 0.2-1 part of a catalyst, 10-20 parts of an etherifying agent and 10-20 parts of a reaction medium. The nano hydrogel prepared through the preparation method is high in biocompatibility, stable in system, capable of improving the medicine effect of a nano hydrogel carrier and is extremely high in medicine carrying rate and biological antibacterial property.

Description

technical field [0001] The invention relates to the technical fields of polymer chemistry, biochemistry, pharmaceutical preparations and the like, and provides a novel nanometer hydrogel material, a preparation method and application thereof. Background technique [0002] In the 21st century, cardiovascular diseases, tumors and diabetes have become the three major diseases that endanger human health. At present, conventional pharmaceutical preparations used in clinical practice, such as solutions, suspensions or emulsions, have low bioavailability, poor stability, and targeting Due to limitations such as weak sex and certain toxic and side effects, it has gradually failed to meet the needs of clinical medication. The development of nanotechnology is expected to make a breakthrough in this respect. [0003] Compared with traditional drug preparations, nano-drug carriers have specific advantages, as follows: 1) Nano-drug carriers can enter capillaries through blood circulation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J9/26C08L5/04C08L1/28C08L5/16C08L5/08A61K47/36A61K9/00A61K47/40A61K47/38A61K47/26A61K47/10A61P31/04A61K31/635
CPCC08J3/075A61K9/00A61K33/38A61K47/10A61K47/26A61K47/36A61K47/38A61K47/40C08J9/26C08J2201/0446C08J2301/28C08J2305/04C08J2305/08C08J2401/28C08J2405/04C08L1/284C08L5/04C08L5/08C08L5/16C08L2205/03
Inventor 秦大伟袁晓彤
Owner QILU UNIV OF TECH
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