A method for non-invasive detection of ultraviolet light-induced skin damage in vivo and its detection equipment

A detection equipment, a technology for skin damage, applied in the directions of diagnostic recording/measurement, analysis using fluorescence emission, medical science, etc., can solve the problems of inaccuracy, clarity, poor sensitivity, no application, etc. Prevalence, widely used effects

Active Publication Date: 2019-08-30
JIANGSU KUNHUI BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, such instruments have poor clarity and sensitivity, cannot detect early skin damage caused by ultraviolet light, have no guiding significance for early detection and prevention of skin damage and further skin diseases, and have almost no clinical application
In particular, for dermatology clinics, it is often only possible to make a qualitative assessment of the skin's UV sensitivity using a phototest, in which UV light is irradiated on a non-lighted skin area, such as a patch of skin on the back, and then passed The area of ​​erythema that appears on this skin is used to evaluate the patient's skin UV sensitivity, which is neither accurate nor a direct detection of damage.

Method used

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  • A method for non-invasive detection of ultraviolet light-induced skin damage in vivo and its detection equipment
  • A method for non-invasive detection of ultraviolet light-induced skin damage in vivo and its detection equipment
  • A method for non-invasive detection of ultraviolet light-induced skin damage in vivo and its detection equipment

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Embodiment Construction

[0045] The present invention will be further illustrated by specific description below.

[0046] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0047] The term "ultraviolet light" used in the present invention means electromagnetic radiation with a wavelength in the range of 100-400nm, including naturally occurring light, such as UVA, UVB, UVC, etc. in sunlight, and artificially generated wavelengths. range of light. The ultraviolet light referred to in the present invention includes continuous electromagnetic radiation, pulsed electromagnetic radiation and modulated electromagnetic radiation, etc., and its intensity is not particularly limited.

[0048] The term "ultraviolet light-induced skin damage" used in the present invention means skin tanning, sunburn, skin photoaging, skin allergic reaction, skin cancer and other damages caused...

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Abstract

The invention provides a method for non-invasive detection of skin damage induced by ultraviolet light in a living body and a detection device thereof. After the skin is irradiated with ultraviolet light, the subcutaneous autofluorescence with a wavelength of 490-640nm will be generated under the excitation of the excitation light with a wavelength of 440-510nm. This change in autofluorescence with a wavelength of 490-640nm is positively correlated with skin damage.

Description

technical field [0001] The invention relates to a detection method and detection equipment for the autofluorescence of organisms. Specifically, it relates to a method for in vivo non-invasive detection of skin damage induced by ultraviolet light and a detection device thereof. Background technique [0002] The ultraviolet light in the sun is the main reason for the damage of human skin by ultraviolet radiation. Ultraviolet radiation will cause various pathological effects on the skin, such as skin redness, peeling, inflammation, ulceration, and various skin diseases, etc., and will cause A large number of active oxides can cause DNA damage in subcutaneous cells and accelerate skin aging. In fact, 90% of human skin aging is due to ultraviolet light exposure, and the most serious disease induced by ultraviolet light is skin cancer. Studies have proved that more than 90% of skin cancers are caused by ultraviolet light exposure in sunlight . Skin cancer patients account for 4...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
CPCA61B5/0071A61B5/0064A61B5/441A61B2503/40A61B2503/42A61B5/445A61B5/00A61B5/0062
Inventor 殷卫海贺号张铭超张洁
Owner JIANGSU KUNHUI BIOTECH CO LTD
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