Human plasma with multiple functions and preparation method thereof

A technology of human plasma and blood plasma, which is applied in the field of plasma, can solve the problems of consuming a lot of time for patients and wasting blood transfusion equipment, and achieve the effects of saving blood transfusion time, increasing the scope of use, and rich and extensive sources of raw materials

Inactive Publication Date: 2016-08-10
杜祖英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main problem of the above method is: because the plasma and various blood components are output multiple times independently, on the one hand, it takes a lot of time for the patient; on the other hand, it also wastes blood transfusion equipment

Method used

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  • Human plasma with multiple functions and preparation method thereof
  • Human plasma with multiple functions and preparation method thereof
  • Human plasma with multiple functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0058] The general-purpose plasma provided in this example is liquid general-purpose fresh frozen plasma:

[0059] The volume parts of plasma of various blood types are:

[0060] Type A plasma: 5 parts by volume Type B plasma: 3 parts by volume

[0061] Type O plasma: 1 part Type AB plasma: 1 part by volume

[0062] The preparation method is:

[0063] The collected qualified plasma was quickly frozen at -30°C, and the four blood types plasma of A, B, O and AB were mixed according to the above volume ratio, and after the virus was inactivated, an appropriate amount of protective agents mannitol and glucose were added, and ultrafiltration was concentrated , Sterilized.

[0064] Universal plasma preparation method embodiment 3

[0065] The general-purpose plasma provided in this example is liquid general-purpose fresh frozen plasma:

[0066] The volume parts of plasma of various blood types are:

[0067] Type A plasma: 6 parts by volume Type B plasma: 3 parts by volume

[...

preparation Embodiment 2

[0115]Take 10ml of general-purpose fresh frozen plasma prepared in Example 2 of general-purpose plasma preparation, and keep the temperature of general-purpose fresh-frozen plasma at 20-24°C in a fully enclosed, sterile and pyrogen-free operating environment. Oscillation frequency per minute and amplitude of 10 mm make the general-purpose fresh frozen plasma oscillate. Under the oscillation, slowly add 3 million platelets and 100 mg of fibrinogen to the general-purpose fresh frozen plasma at a drop rate of 30 L / hr;

[0116] After the blood component additives are added, the final human plasma with multiple functions is prepared.

preparation Embodiment 3

[0118] Take 10ml of general-purpose fresh frozen plasma prepared in Example 3 of general-purpose plasma preparation, and keep the temperature of general-purpose fresh-frozen plasma at 20-24°C in a fully enclosed, sterile and pyrogen-free operating environment. At the same time, press 8 Oscillation frequency per minute and 7mm amplitude make the general-purpose fresh frozen plasma oscillate. Under the oscillation, slowly add coagulation factor II 0.1mg, coagulation factor V 10mg, Coagulation factor IX 0.03mg, coagulation factor XI 0.005mg, coagulation factor XIII 2mg and gamma globulin 30mg;

[0119] After the blood component additives are added, the final human plasma with multiple functions is prepared.

[0120] Example 4 of Multifunctional Human Plasma Preparation

[0121] Take 10ml of general-purpose fresh frozen plasma prepared in Example 4 of general-purpose plasma preparation, and keep the temperature of general-purpose fresh frozen plasma at 20-24°C in a fully enclosed...

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PUM

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Abstract

The invention provides a human plasma with multiple functions and a preparation method thereof, including general-purpose plasma and blood component additives; the general-purpose plasma is general-type fresh frozen plasma or general-purpose freeze-dried plasma; the blood component additive is selected from albumin, C Globulins, platelets, fibrinogen, factor II, factor V, factor VII, factor VIII, factor IX, factor X, factor XI, factor XII, factor XIII, and prothrombin complex any one or more of them. The advantages are: for patients who need to supplement plasma and at least one blood component additive at the same time, only the plasma including the corresponding blood component additive needs to be transfused, thereby increasing the scope and flexibility of use, saving the patient's blood transfusion time, and saving Blood transfusion equipment.

Description

technical field [0001] The invention relates to plasma, in particular to human plasma with multiple functions and a preparation method thereof. Background technique [0002] Over the past ten years, with the in-depth research on the physiology and pathology of blood transfusion and the accumulation of clinical experience, plasma, as a supplement of human blood, has been increasingly used clinically. Because there are four blood types A, B, O and AB in the human ABO blood group system. At present, for patients with four different blood types, the methods of plasma transfusion are as follows: first, plasma of four different blood types needs to be prepared, and the prepared plasma products must be stored separately, which is very inconvenient; Blood type identification and cross-matching, the process of using plasma is very cumbersome, resulting in delays in the rescue of emergency patients. [0003] In order to solve the above existing problems, a universal plasma is disclo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/16A61K38/38A61K38/39A61K35/19A61K38/36A61K38/37A61K38/48A61K39/395A61P7/08
Inventor 杜祖英
Owner 杜祖英
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