Surface-enhanced Raman substrate material and preparation method thereof

A surface-enhanced Raman and substrate material technology, applied in the analysis of materials, Raman scattering, material excitation analysis, etc., can solve the problems of limitations, gold nanoparticles are easy to agglomerate, and it is difficult to obtain uniform morphology, so as to achieve high Raman The effect of enhanced activity, simple construction method, and good stability

Inactive Publication Date: 2016-08-03
SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of this technology is that sodium borohydride has strong reducing performance, and it is difficult to obtain carbon-based quantum dots / nano-silver composites with controllable morphology and good reproducibility, thus limiting its application.
The Chinese patent (publication number 104999088A) proposes to use polyethyleneimine and polyacrylic acid as polyelectrolytes, and use the charge and reduction properties of the electrolyte to prepare gold nanoparticles-reduced graphene oxide multilayer film composites. The disadvantage of this technology is that the original electrolyte The gold nanoparticles obtained by site reduction are easy to agglomerate, and it is difficult to obtain composite graphene-based nanomaterials with uniform and controllable morphology.

Method used

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  • Surface-enhanced Raman substrate material and preparation method thereof
  • Surface-enhanced Raman substrate material and preparation method thereof
  • Surface-enhanced Raman substrate material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] 1) Add 1g flake graphite to a 200mL beaker in a low-temperature ice bath, then add 60mL of 98% concentrated sulfuric acid, and slowly add 6g of potassium permanganate (completely added in about 30min) under magnetic stirring for 30min of reaction. The above beaker was placed in a water bath at 35° C. to react for 2 hours, and the entire solution system would become viscous as the medium temperature time was further prolonged. After the reaction is over, take out the beaker and put it in a high temperature 85°C oil bath, slowly add 20mL of water with a burette (after 40 minutes, if the addition rate is too fast, the reaction temperature is not easy to control), and react for 20 minutes (prolong the high temperature time, the solution It will gradually turn yellow or bright yellow, you don't need to add hydrogen peroxide), add 10mL of hydrogen peroxide. Centrifugation was performed four times at room temperature, the precipitate was washed with double distilled water, and...

Embodiment 2

[0035] 1) Dissolve the above 1mg of graphene oxide and 400mg of cysteine ​​in 10mL of twice distilled water, make it react in a phosphate (PBS) buffer system, stir at room temperature for 24 hours, and perform 3 times of high-speed Centrifuge to remove excess cysteine, wash the precipitate with twice distilled water, and redissolve the precipitate in 5 mL of phosphate (PBS) buffer.

[0036] 2) Centrifuge 8 mL of the synthesized nano-silver sol (concentration is about 1 mg / mL) into step 1, and stir and react for 12 hours at room temperature. The obtained reaction solution is subjected to high-speed centrifugation twice to remove excess nano-silver particles, and the obtained precipitate is dissolved in water again. The desired surface-enhanced Raman substrate material can be obtained.

[0037] 3) get 1mL composite material in embodiment 2, add the gradient concentration solution (10 -3 , 10 -4 ,10 -5 ,10 -6 ,10 -7 ,10 -8 , 10 -9 mol / L Figure 4 middle from top to botto...

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Abstract

The invention discloses a surface-enhanced Raman substrate material and a preparation method thereof. By using graphene oxide as a template and carrier, cysteine modification and nano silver particle self-assembly are performed on the surface of the graphene oxide. The preparation method comprises the following steps: 1) dissolving graphene oxide and cysteine in redistilled water, carrying out reaction in a PBS (phosphate buffer solution) system under room temperature conditions, carrying out centrifugal separation after the reaction finishes, washing the obtained precipitate, and dissolving the washed precipitate in a PBS buffer solution to obtain a first solution; and 2) adding a nano silver colloidal solution into the first solution, reacting at room temperature, carrying out centrifugal separation, and dissolving the obtained precipitate in water, thereby obtaining the surface-enhanced Raman substrate material. The surface-enhanced Raman substrate material has the characteristics of small environmental pollution, low cost and the like, is simple to operate, and has favorable surface enhancement effects on organic molecule Raman detection.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a surface-enhanced Raman base material and a preparation method thereof. Background technique [0002] Surface-enhanced Raman scattering (SERS) refers to the phenomenon that the Raman signal of the target molecule can be greatly enhanced when the target molecule is adsorbed on the surface of some metal (such as gold, silver, copper, etc.) particles. SERS technology has extremely high detection sensitivity and selectivity for the molecules to be detected. It can observe the chemical structure and composition of various substances at the interface in real time at the molecular level, and promote the breakthrough development of Raman technology. [0003] Since the discovery of the SERS phenomenon, people have been studying the enhancement mechanism of SERS. However, due to the complexity of the SERS system, decades have passed, and people have not been able to clearly e...

Claims

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Application Information

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IPC IPC(8): C01B31/04G01N21/65B22F9/24
CPCB22F9/24C01P2002/82C01P2004/04G01N21/658
Inventor 贾少杰李丹徐虎李东杜晗王宇红
Owner SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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