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Chlorpropamide drug composition and pharmaceutical application thereof

A technology of chlorpropamide and its composition, which is applied in the field of pharmaceutical composition of chlorpropamide, can solve the problems that have not yet been reported related to chlorpropamide cardiomyopathy, and achieve outstanding substantive characteristics, strong effect, and significant progressive effect

Inactive Publication Date: 2016-07-27
何华琼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between chlorpropamide and its pharmaceutical composition and diabetic cardiomyopathy

Method used

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  • Chlorpropamide drug composition and pharmaceutical application thereof
  • Chlorpropamide drug composition and pharmaceutical application thereof
  • Chlorpropamide drug composition and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Grind the dry root tuber (2kg) of Morinda officinalis, extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether ( 3L×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) The n-butanol extract in step (a) is removed with D101 type macroporous resin, first elutes 8 column volumes with 10% ethanol, then elutes 10 column volumes with 70% ethanol, collects 70% eluat...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] 40 Wistar rats aged 3 to 4 months, half male and half male, weighing 210 g to 250 g, were provided by the Experimental Animal Center of Jiamusi University. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0029] 1.2 Reagents and samples

[0030] Chlorpropamide was purchased from China National Institutes for Food and Drug Control. Compound (I) is self-made, and the preparation method is shown in Example 1. Streptozotocin (STZ) was purchased from Sigma Company of the United States; SOD, Coomassie Brilliant Blue protein assay kits were purchased from Nanjing Jiancheng Bioengineering Institute. Triglyceride kit was purchased from Changchun Huili Engineering Technology Development Center.

[0031] 1.3 Instruments ...

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Abstract

The invention discloses a chlorpropamide drug composition and pharmaceutical application thereof. The chlorpropamide drug composition provided by the invention contains chlorpropamide and a natural product compound (I) with a novel structure obtained from dried tubers of Morinda officinalis through separation, wherein the chlorpropamide and the compound (I) can protect the antioxidant enzyme activity of a rat, remove free radicals and inhibit lipid peroxidation, antioxidation prompting is one of mechanisms that the chlorpropamide and the compound (I) protect DM rat kidneys. After the chlorpropamide and the compound (I) are jointly used, the effect of regulating blood fat of the rat having diabetes type 2 and the effect of protecting the kidneys are further improved, early application can effectively delay the occurrence and development of kidney lesions caused by diabetes, a drug for treating the kidney lesions caused by diabetes can be developed, and as compared with the prior art, the invention has prominent substantive features and a notable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of chlorpropamide, in particular to a pharmaceutical composition of chlorpropamide and its medical application. Background technique [0002] The indication of chlorpropamide is suitable for mild and moderate type Ⅱ diabetes mellitus whose curative effect is not satisfied with diet alone. The patient's islet β cells have a certain function of secreting insulin, and there is no serious complication. This product can also be used for central diabetes insipidus. [0003] So far, there is no report on the correlation between chlorpropamide and its pharmaceutical composition and diabetic cardiomyopathy. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of chlorpropamide, which contains chlorpropamide and a natural product, and the chlorpropamide and the natural product can synergistically treat diabetic nephro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/64A61K31/357A61P3/10A61P13/12
CPCA61K31/357A61K31/64C07D493/08A61K2300/00
Inventor 何华琼
Owner 何华琼
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