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Injectable biological calcium salt compound bone cement and preparation method thereof

A technology of bone cement and biological calcium, used in tissue regeneration, medical science, prosthesis, etc., to achieve the effects of easy extrusion, convenient injection, and low cost

Active Publication Date: 2016-07-20
GUANGZHOU ANZE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the deficiencies of existing bone cement materials, the object of the present invention is to provide an injectable bio-calcium salt composite bone cement

Method used

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  • Injectable biological calcium salt compound bone cement and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Put 65 parts of pharmaceutical grade α-calcium sulfate hemihydrate, 8 parts of calcium phosphate and 2 parts of anhydrous calcium citrate enhancer in absolute ethanol, grind for 40 minutes at room temperature, and obtain component A after drying; 20 parts of powder Cancellous bone extracellular matrix (particle size: 0.1-0.2 mm) and 0.5 parts of calcium stearate are directly ground and blended in a dry state to obtain component B. When in use, first add component A to an appropriate amount of sterile water for injection (the solid-liquid ratio of components A and B to sterile water for injection is 2.5g / mL) under stirring, and stir continuously for 1-2 minutes to make a uniform paste shape, then add component B, stir for 30-60 seconds, and transfer to the bone cement delivery equipment for injection delivery and solidification.

Embodiment 2

[0043] Put 70 parts of pharmaceutical grade α-calcium sulfate hemihydrate, 10 parts of calcium phosphate and 1 part of anhydrous calcium tartrate enhancer in absolute ethanol, grind for 60 minutes at room temperature, and obtain component A after drying; 10 parts of powdered pine Bone extracellular matrix (particle size: 0.05-0.1 mm) and 0.1 part of magnesium stearate are directly ground and blended in a dry state to obtain component B. When in use, add component A into an appropriate amount of normal saline (the solid-to-liquid ratio of components A and B to normal saline is 2.0g / mL) under stirring, keep stirring for 1-2 minutes to make it into a uniform paste, and then Add component B, stir for 30-60 seconds, and transfer to the bone cement delivery equipment for injection delivery and solidification.

Embodiment 3

[0045] Put 60 parts of pharmaceutical grade α-calcium sulfate hemihydrate, 5 parts of calcium phosphate, and 5 parts of anhydrous calcium tartrate in absolute ethanol, grind for 50 minutes at room temperature, and obtain component A after drying; 30 parts of powdered cancellous bone The extracellular matrix (particle size: 0.1-0.25 mm) and 3 parts of calcium stearate are directly ground and blended in a dry state to obtain component B. When in use, add component A into an appropriate amount of sterilized PBS physiological buffer (the solid-liquid ratio of components A and B to the buffer is 3.0g / mL) under stirring, and stir continuously for 1min to make it into a uniform paste. Then add component B, stir for 30-60 seconds, and transfer to the bone cement delivery equipment, which can be injected, delivered and solidified.

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Abstract

The invention discloses injectable biological calcium salt compound bone cement and a preparation method thereof.The bone cement is composed of powder and liquid, the powder comprises a component A and a component B, and the component A is prepared from alpha-calcium sulfate hemihydrates, calcium phosphate and an enhancer.The component B is prepared from a bone extracellular matrix and a water-resistant lubricant.A calcium sulfate-calcium phosphate-powdery cancellous bone extracellular matrix basic system is adopted, but the amount of calcium phosphate in the system is further reduced, calcium phosphate is replaced with the calcium enhancer, the calcium enhancer can enhance the overall mechanical strength of the material like calcium phosphate, and the degradation and absorption capacity is superior to that of calcium phosphate.The water-resistant lubricant to which calcium ingredients are added can lubricate the whole material during stirring injection, injection is convenient, and the biological property, mechanical property and injectable performance of an existing calcium bone cement material can be improved.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an injectable bio-calcium salt composite bone cement and a preparation method thereof. Background technique [0002] Bone defects, ruptures, compression fractures, osteoporosis and other diseases caused by traffic accidents, industrial injuries, diseases, and aging have always plagued human health. The usual recommended treatment is instrumented reduction and bone grafting. However, for the thoracolumbar spine, the damage caused by open wound surgery is too high, and the risk is too high. If only the instrument is reset, it will take a very long time to rely on the body to repair. Through the injection of self-solidifying materials such as bone cement, combined with instrument reset, only a very small trauma is required to reinforce the defective bone. Compared with the commonly used acrylate bone cement, phosphate bone cement has the characteristics of promoting bone regene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/36A61L27/50
CPCA61L27/025A61L27/12A61L27/3633A61L27/365A61L27/50A61L2430/02
Inventor 别拓铭杨伟红官习鹏
Owner GUANGZHOU ANZE REGENERATIVE MEDICINE TECH CO LTD
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