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Application of syringaldehyde in the preparation of protective drugs for intestinal damage caused by ionizing radiation

A technology of ionizing radiation and syringaldehyde is applied in the directions of drug combination, aldehyde active ingredients, digestive system, etc., which can solve the problems of low activity, high concentration, toxic and side effects, etc. Effect

Active Publication Date: 2018-08-21
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the research on protective drugs for intestinal damage caused by ionizing radiation is mostly in the preclinical stage. Although some drugs have protective effects, they have significant shortcomings, mainly including: high concentration, low activity, and obvious toxic and side effects, which limit clinical application. Finding non-toxic or low-toxic, highly effective protective drugs for intestinal damage caused by ionizing radiation has always been a hot pursuit in the medical field

Method used

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  • Application of syringaldehyde in the preparation of protective drugs for intestinal damage caused by ionizing radiation
  • Application of syringaldehyde in the preparation of protective drugs for intestinal damage caused by ionizing radiation
  • Application of syringaldehyde in the preparation of protective drugs for intestinal damage caused by ionizing radiation

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Effect test

Embodiment 1

[0028] Firstly, a mouse model of intestinal injury induced by radiation was established. C57BL / 6 mice aged 6-8 weeks, half male and half male (body weight 25±2g), were randomly divided into two groups: 8 mice in the irradiation group (10Gy) and syringaldehyde mice before irradiation. There were 8 mice in the administration group (10Gy+syringaldehyde); the whole body of the mice was uniformly irradiated with a single X-ray irradiation machine, and the absorbed dose of the mice was 10Gy. The syringaldehyde was dissolved in 0.5% sodium carboxymethylcellulose aqueous solution with a mass concentration of 0.5%, wherein the concentration of syringaldehyde was 5mg / ml, and the mice in the syringaldehyde administration group were administered by intragastric administration (dosage according to body weight: 100mg / kg) Irradiation was carried out 1 hour later, and the mice in the irradiation group were given an aqueous solution of 0.5% sodium carboxymethylcellulose in the same volume and m...

Embodiment 2

[0030] The rat intestinal epithelial cell IEC-6, which is more recognized in the research of intestinal injury in vitro, was selected as the model. Dissolve syringaldehyde in dimethyl sulfoxide, the concentration of the mother solution is 40mmol / L, and prepare and use syringaldehyde solutions with concentrations of 5, 10, 20, and 40μmol / L respectively by the method of serial dilution, and the dilution is for culturing cells DMEM medium. The control group was treated with an equal volume of DMSO in 40 μmol / L syringaldehyde solution. IEC-6 cells were seeded in a 96-well plate. When the cells were in the logarithmic growth phase, the above-mentioned different concentrations of syringaldehyde solution and dimethyl sulfoxide were added respectively. After 72 hours of treatment, CCK8 (purchased from Beyond Biotechnology Co., Ltd., operated The method followed the instructions) to detect cell growth. The results are attached figure 2 As shown, 40 μmol / L syringaldehyde still did n...

Embodiment 3

[0032] (1) Firstly, a mouse model of intestinal injury induced by cobalt-60γ-rays was established. Select 6-8 weeks old C57BL / 6 mice, half male and half male (body weight 25±2g), and randomly divide them into four groups: 6 mice in the blank group without irradiation treatment, 6 mice in the normal feeding group, 6 mice in the irradiation group, and syringaldehyde before irradiation. There were 6 rats in the drug group (irradiation + syringaldehyde), and 6 rats in the positive control flagellin administration group (irradiation + CBLB502) before irradiation. The mice were uniformly irradiated with a cobalt-60γ-ray source, and the absorbed dose of the mice was 9Gy. The syringaldehyde was dissolved in 1% sodium carboxymethyl cellulose aqueous solution in which the concentration of syringaldehyde was 10mg / ml, and the mice in the syringaldehyde administration group were administered by intragastric administration (dosage according to body weight: 100mg / kg) Irradiation was carried...

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Abstract

The present invention provides an application of syringaldehyde in the preparation of a drug for preventing intestinal injuries caused by ionizing radiation, a dosage form, and an administration mode. The drug for preventing intestinal injuries caused by ionizing radiation using syringaldehyde as an active ingredient has the advantages such as small toxic and side effect, remarkable treatment effect, and convenient and safe to use, is suitable for different people such as acute radiation syndrome patients, nuclear personnel, officers and soldiers, astronauts, and radiotherapy patients, and can be used before treatment or during task execution and work. Syringaldehyde shows unique performance in prevention of intestinal injuries caused by ionizing radiation, and has a wide application prospect in the medical field of China.

Description

technical field [0001] The invention relates to the application of syringaldehyde, in particular to the application of syringaldehyde in the preparation of protective medicine for intestinal damage caused by ionizing radiation. Background technique [0002] With the extensive development and utilization of nuclear energy in my country and the rapid development of nuclear medicine, the chances of people being exposed to ionizing radiation are increasing day by day. The Fukushima nuclear power plant accident in 2011 and the recent North Korean nuclear crisis once again remind us that nuclear threats still exist. [0003] The small intestine is very sensitive to ionizing radiation because of the extremely fast renewal of epithelial cells, and is the most important target organ of ionizing radiation. Intestinal damage caused by ionizing radiation is one of the important causes of early death in patients with acute radiation sickness. In addition, patients with malignant tumors ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61P1/00
CPCA61K31/11
Inventor 尚增甫谷蒙蒙周平坤肖倍倍李明薛培君卢双双
Owner SUZHOU UNIV
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