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Toothpaste composition with strong antibacterial function

A technology of composition and toothpaste, which is applied in the direction of antibacterial drugs, drug combinations, dentistry, etc., can solve the problems such as the weakening of exogenous biological enzymes, achieve strong cleaning and decontamination capabilities, and reduce the amount of bacteria

Active Publication Date: 2018-11-06
ANHUI LEVEKING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral microorganisms can secrete enzymes to degrade exogenous biological enzymes and resist the decomposition of exogenous biological enzymes, which weakens the effectiveness of exogenous biological enzymes

Method used

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  • Toothpaste composition with strong antibacterial function
  • Toothpaste composition with strong antibacterial function
  • Toothpaste composition with strong antibacterial function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kg of toluene and 4.48 kg of linear octylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=8, n= 210), 0.52 kg of phthalic anhydride, stirred at a stirring speed of 150 rpm for 30 minutes to make linear octylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=8, n=210) and phthalic anhydride are fully dissolved in toluene; then add 0.05 kg of p-toluenesulfonic acid, and stir at a stirring speed of 150 rpm for 10 minutes, p-toluenesulfonic acid catalyzes linear octylphenol polyoxygen Ethyl ether (alkylphenol polyoxyethylene ether, R=8, n=210) undergoes an esterification reaction with phthalic anhydride; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; Finally remove the water in the water separator, utilize the vacuum pump to remove toluene, cool to room temperature, obtain the diester surfactant, and the diester surfactant ...

Embodiment 2

[0057] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kg of toluene and 4.92 kg of isooctylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=12, n=500 ), 0.08 kg of phthalic anhydride, and stirred at a stirring speed of 150 rpm for 30 minutes to make isooctylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=12, n=500) and o- Fully dissolve phthalic anhydride in toluene; add 0.003 kg of phosphoric acid, and stir for 10 minutes at a stirring speed of 150 rpm, phosphoric acid catalyzes isooctylphenol polyoxyethyl ether (alkylphenol polyoxyethylene ether, R=12 , n=500) and phthalic anhydride to undergo esterification reaction; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; finally remove the water in the water separator and use a vacuum pump to remove Toluene is cooled to room temperature to obtain the diester surfactant, and the diester surfactant structure is as follows:

...

Embodiment 3

[0061] In a 10-liter esterification reaction kettle with a condenser and a water separator, 5 kilograms of toluene and 4.85 kilograms of linear dodecylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=18, n=360), 0.15 kg of phthalic anhydride, stirred at a stirring speed of 150 rpm for 30 minutes to make linear dodecylphenol polyoxyethylene ether (alkylphenol polyoxyethylene ether, R=18, n=360) and phthalic anhydride are fully dissolved in toluene; then add 0.02 kg of benzenesulfonic acid, and stir at a stirring speed of 150 rpm for 10 minutes, benzenesulfonic acid catalyzes the linear dodecylphenol polyoxygen Ethyl ether (alkylphenol polyoxyethylene ether, R=18, n=360) undergoes an esterification reaction with phthalic anhydride; heat up to 110°C, stir at a stirring speed of 150 rpm, and reflux for 4 hours; Finally remove the water in the water separator, utilize the vacuum pump to remove toluene, cool to room temperature, obtain the diester surfactant, and t...

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Abstract

The invention discloses a toothpaste composition with a strong antibacterial function. The toothpaste composition comprises a grinding agent, a humectant, an adhesive, a diester type surfactant, compound enzymes, a sweetener, perfume, mannatide, and deionized water. Biological enzymes cooperatively decompose the extracellular polymers excreted by floras of dental plaque, cell walls and cell membranes; during the decomposition process, hydrogen peroxide and hydroperoxide are generated at the same time; hydrogen peroxide and hydroperoxide can oxidize and neutralize high level mercapto groups in the biological membranes of dental plaque, oxidize and kill cells of bacteria at the same time, and reduce the resistance of bacterium cells to exogenous biological enzymes; at the same time, the decomposition product of mannatide can cut off the glycan chain of cell walls of bacteria, and absorb the pathogenic bacteria to starve the pathogenic bacteria; the diester type surfactant has a strong cleaning and stain-removing ability, and is capable of strongly removing biological membranes of dental plague and bacterium residues; after the using of the toothpaste, the average colony-forming units are reduced by 84.6 to 88.3%, and the number of bacteria is obviously reduced.

Description

technical field [0001] The invention belongs to the technical field of daily necessities, in particular to an enzyme-containing toothpaste composition with strong antibacterial function. Background technique [0002] Dental plaque biofilm is an ecosystem composed of a variety of flora on the tooth surface or in the periodontal pocket. Bacteria grow, develop and die within. Its complex structure enables it to contain bacteria of varying sensitivity to oxygen embedded in a matrix composed of polysaccharides, proteins and minerals. The metabolic activities of bacteria in it affect the dynamic balance between bacteria and hosts or between bacterial genera. Plaque biofilms are present on almost all tooth surfaces and adhere so strongly to tooth surfaces that they are difficult to remove, even with vigorous brushing activity. After the plaque is formed on the teeth, if it is not removed promptly and effectively, the plaque will continue to expand and eventually lead to gingivit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/66A61K8/86A61Q11/00A61P1/02A61P31/04
Inventor 郭宏涛王剑英聂新华黄长龙林智
Owner ANHUI LEVEKING BIOTECH CO LTD
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