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Hibiscus sabdariffa volatile oil, preparation method and application to preparation of anti-inflammatory drugs

A technology of roselle and volatile oil, applied in the directions of anti-inflammatory agents, drug combinations, antipyretics, etc., can solve the problem of whether roselle volatile oil is anti-inflammatory or not.

Active Publication Date: 2016-06-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no research on the anti-inflammatory effect of roselle volatile oil

Method used

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  • Hibiscus sabdariffa volatile oil, preparation method and application to preparation of anti-inflammatory drugs
  • Hibiscus sabdariffa volatile oil, preparation method and application to preparation of anti-inflammatory drugs
  • Hibiscus sabdariffa volatile oil, preparation method and application to preparation of anti-inflammatory drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0059] Embodiment 1 prepares Roselle volatile oil I from Roselle

[0060] (1) Crush roselle (Hibiscus sabdariffa) and sieve to obtain roselle coarse powder; weigh 100g of roselle coarse powder, add 2000mL of distilled water to a 5000mL round bottom flask, shake well and soak for 30min; obtain the extract ;

[0061] (2) Accurately connect the steam distillation device, place the extract obtained in step (1) in the steam distillation device, and add distilled water from top to bottom to the scale until it overflows ( Figure 14 ), using steam distillation to extract volatile oil: after boiling, keep at 100°C for 6 hours; stop heating and cool for 30 minutes to condense all the volatile oil in the condensing tube to reduce volatilization; release the distilled water in the scale section, and then use ether to distill the volatile oil in the condensing tube Transfer the volatile oil to the Erlenmeyer flask, add excess anhydrous sodium sulfate to remove water (slowly add anhydrous...

Embodiment 2

[0062] Embodiment 2 prepares Roselle volatile oil I from Roselle

[0063] (1) Crush roselle (Hibiscus sabdariffa) and sieve to obtain roselle coarse powder; weigh 100g of roselle coarse powder, add 3000mL of distilled water to a 5000mL round bottom flask, shake well and soak for 40min; obtain extract ;

[0064] (2) Accurately connect the steam distillation device, place the extract obtained in step (1) in the steam distillation device, and add distilled water from top to bottom to the scale until it overflows ( Figure 14 ), using steam distillation to extract volatile oil: after boiling, keep at 100°C for 5 hours; stop heating and cool for 20 minutes to condense all the volatile oil in the condensing tube to reduce volatilization; release the distilled water in the scale section, and then use ether to distill the volatile oil in the condensing tube Transfer the volatile oil to the Erlenmeyer flask, add excess anhydrous sodium sulfate to remove water (slowly add anhydrous sod...

Embodiment 3

[0065] Embodiment 3 prepares Roselle volatile oil I from Roselle

[0066] (1) Crush roselle (Hibiscus sabdariffa) and sieve to obtain roselle coarse powder; weigh 100g of roselle coarse powder, add 1000mL of distilled water to a 5000mL round bottom flask, shake well and soak for 1h; obtain the extract ;

[0067] (2) Accurately connect the steam distillation device, place the extract obtained in step (1) in the steam distillation device, and add distilled water from top to bottom to the scale until it overflows ( Figure 14 ), using steam distillation to extract volatile oil: after boiling, keep at 100°C for 8 hours; stop heating and cool for 40 minutes to condense all the volatile oil in the condensing tube to reduce volatilization; release the distilled water in the scale section, and then use ether to distill the volatile oil in the condensing tube Transfer the volatile oil to the Erlenmeyer flask, add excess anhydrous sodium sulfate to remove water (slowly add anhydrous so...

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Abstract

The invention belongs to the field of traditional Chinese medicine and particularly relates to hibiscus sabdariffa volatile oil, a preparation method and application to preparation of anti-inflammatory drugs. According to the hibiscus sabdariffa volatile oil, the preparation method and application to preparation of the anti-inflammatory drugs, the hibiscus sabdariffa volatile oil is extracted from hibiscus sabdariffa through a vapor distillation method. In addition, hibiscus sabdariffa volatile oil II and hibiscus sabdariffa volatile oil III are obtained through microwave treatment and ultrasonic treatment respectively. The three types of volatile oil can remarkably inhibit releasing of RAW264.7 macrophage NO induced by LPS in vitro, and by means of the volatile oil III, expression of RAW264.7 macrophage TNF-alpha, iNOS, IL-1, IL-6 and COX-2mRNA induced by LPS can be remarkably inhibited. By means of the hibiscus sabdariffa volatile oil III, expression of NF-kappaB and phosphorylated JNK and ERK1 / 2 protein can be lowered, and the hibiscus sabdariffa volatile oil can be applied to preparation of the anti-inflammatory drugs.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a roselle volatile oil, a preparation method and an application in preparation of anti-inflammatory drugs. Background technique [0002] The volatile oil of traditional Chinese medicine, also known as essential oil, is a kind of volatile oily component that is immiscible with water and can be obtained by steam distillation in plants, and often has a specific aromatic smell. In traditional Chinese medicine, many medicinal materials contain volatile oil components, which usually have strong pharmacological activity. For example, bupleurum volatile oil has a good antipyretic effect, peppermint oil has cooling and anti-inflammatory effects, garlic oil can treat bronchitis, pneumonia and fungal infection, ginger oil has antipyretic, analgesic and sedative effects, and Chuanxiong oil has the effect of expanding cerebral blood vessels , the volatile oils of fran...

Claims

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Application Information

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IPC IPC(8): C11B9/02A61K36/185A61P29/00
CPCA61K36/185C11B9/025C11B9/027
Inventor 姜建国张恬恬张文莉
Owner SOUTH CHINA UNIV OF TECH
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