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Lafutidine chewing tablet and preparation method thereof

A technology of lafutidine and chewable tablets, which is applied in the field of lafutidine chewable tablets and its preparation, can solve the problems of not being able to improve gastrointestinal digestion, not being able to control drug release well, and general therapeutic effects, etc., to achieve Prevention of ulcer recurrence, promotion of ulcer healing, and sustained effect of anti-gastric acid secretion

Inactive Publication Date: 2016-06-22
HEILONGJIANG ZHICHENG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the existing products on the market have mediocre therapeutic effect, great stimulation to the gastrointestinal tract, cannot improve gastrointestinal digestion well, and cannot control drug release well Not enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A lafutidine chewable tablet is characterized in that: it is made up of following raw materials: lafutidine, filler, flavoring agent, binding agent, coating agent, lubricant are made; By weight percentage, wherein Lafutidine Futidine 5-10%, filler 10-30%, flavoring agent 0.1-80%, binder 0.1-20%, coating agent 1-10%, lubricant 0.05-10%.

[0024] The filler is one or more of starch, dextrin and microcrystalline cellulose.

[0025] The flavoring agent is one or a mixture of aspartame, stevia, mannitol, sorbitol, lactose and sucrose.

[0026] The binder is one of povidone k30, hypromellose, syrup and starch slurry.

[0027] The coating agent is one or a mixture of povidone k30, hypromellose, ethyl cellulose and carboxymethyl cellulose.

[0028] The lubricant is one or more of magnesium stearate, silicon dioxide, talcum powder and sodium lauryl sulfate.

[0029] The concrete steps of its preparation method are:

[0030] Step 1, select lafutidine, filler, ...

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PUM

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Abstract

The present invention discloses a lafutidine chewing tablet and a preparation method thereof, the lafutidine chewing tablet is prepared from lafutidine, a filler, a flavoring agent, a binder, a coating agent and a lubricant; the lafutidine chewing tablet is a highly-efficient long-acting H2 receptor antagonist, has obvious inhibitory effect on gastric acid secretion, can inhibit gastric acid secretion caused by histamine, pentagastrin, food and the like, has gastric mucosal protective effect, has dose-dependent inhibition effect on the formation of a variety of experimental animal ulcer models, promotes ulcer healing, relieves symptoms and prevents ulcer recurrence. The lafutidine chewing tablet is easy to take, can promote drug dissolution and absorption in the body, even in a water deficiency state, can ensure medication on time, is especially suitable for the elderly, children, stroke patients, and patients with poor gastrointestinal functions and swallowing difficulties, and may reduce gastrointestinal tract drug burdens.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a lafutidine chewable tablet and a preparation method thereof. Background technique [0002] Lafutidine receptor antagonist, has a unique gastroprotective effect. It can reduce the basal secretion of gastric acid and inhibit the secretion of gastric acid stimulated by histamine, gastrin and urethane. Compared with similar drugs such as cimetidine and famotidine, it has a more effective and long-lasting blocking effect on H2 receptors, so it has the advantage of more sustained anti-gastric acid secretion. It is mainly used to treat gastric ulcer, duodenal ulcer and acute or chronic gastritis. [0003] At present, most of the existing products on the market have mediocre therapeutic effects, great stimulation to the gastrointestinal tract, inability to improve gastrointestinal digestion, and inability to control drug release well. Contents of the invention [0004] The obje...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4545A61P1/04
Inventor 张昕
Owner HEILONGJIANG ZHICHENG MEDICAL TECH
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