Ultrasound contrast agent for uterine fallopian tube cavity and preparation method thereof

Abstract

The invention relates to an ultrasonic contrast agent of a uterus oviduct tract and a preparation method of the ultrasonic contrast agent. The ultrasonic contrast agent is prepared from the following components: a first component is a carrier and is composed of phospholipid, polyethylene glycol or a derivative thereof and polymerized phospholipid connected with a specific ligand at the weight ratio of (0.5 to 2):(0.005 to 0.02):(0.003 to 0.007); a second component is a phospholipid stabilizer; a third component is a biological solvent; a fourth component is a fluorocarbon gas; the weight percent ratio of the first component to the second component to the third component is (0.0005 to 0.002):(0.000005 to 0.00002):(0.5 to 2); the concentration of the fourth component which is gas is 10<8>-10<9> / mL.

Description

technical field [0001] The invention relates to a medical contrast agent, in particular to an injectable ultrasound-targeted contrast agent with air-filled microbubbles in an aqueous solution carrier, belonging to the field of medical ultrasound image diagnosis. Background technique [0002] Suspensions of gaseous microbubbles in a carrier liquid act as effective ultrasound reflectors and are well known in the art. With the application of ultrasound, although transvaginal ultrasound has a clearer image of female internal genitalia than the previous abdominal ultrasound, general real-time ultrasound still cannot fully display the course and shape of the fallopian tubes. Or ovarian lesions, can not be clearly displayed. At present, hysterosalpingosalpingography and laparoscopy are commonly used at home and abroad to check the patency of the fallopian tubes, but many patients often have allergic reactions to lipiodol, and the entry of lipiodol contrast agents into the abdomina...

AI Technical Summary

Problems solved by technology

This technology has achieved satisfactory results in diagnosing lesions in the ovary, intrauterine cavity, and fallopian tubes. However, there are some problems with the existing ultrasound contrast agents at home and abroad: for example, the ultrasonic microbubble membrane material has complex components, many materials, and synthetic preparation. In the process, chloroform, tert-butanol and other harmful solvents are used, so it is necessary to select the membrane material and its configuration ratio to prepare more economical, effective, safe and easy-to-prepare microbubbles; the synthesis process is complex and the steps are cumbersome , Ultrasonic cavitation method, mechanical formulation method, freeze-drying method, repeated freeze-thawing method, etc., either the preparation process is more complicated, or the particle size and distribution of the prepared microbubbles are not ideal enough, all of which need further improvement; Too many liposomes in the blood vessel or cavity can not release the gas in time, thus affecting the effect of ultrasound

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