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Coating capable of improving surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloy and preparing method of coating

A biocompatible, magnesium alloy technology, used in coatings, electrolytic coatings, medical science, etc., can solve the problems of inappropriate phosphating methods and poor degradability, and achieve tight arrangement, increased self-corrosion potential, and corrosion resistance. improved effect

Active Publication Date: 2016-05-25
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been some reports on the preparation of CaZn on substrates such as titanium and iron by means of phosphating treatment. 2 (PO 4 ) 2 2H 2 O coating, but the coating obtained by phosphating belongs to the stoichiometric ratio coating, and its degradability is poor. Since magnesium and magnesium alloys are mainly used as degradable implant materials, the coating should also be degradable, so phosphorus method does not apply

Method used

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  • Coating capable of improving surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloy and preparing method of coating
  • Coating capable of improving surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloy and preparing method of coating
  • Coating capable of improving surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloy and preparing method of coating

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Embodiment 1

[0029] A method for preparing a coating for improving the corrosion resistance and biocompatibility of medical magnesium and magnesium alloys, comprising the following steps:

[0030] (1) Pretreatment of the base material: Cut the Mg-Zn-Ca alloy to be treated into a rectangular block of 25mm×10mm×4mm, use it as the base material, and use 100#, 200#, 400#, 600# and 800# #Metallographic sandpaper mechanically polish the surface in turn, and perform ultrasonic cleaning (frequency 40kHz) for 10 minutes in a mixed solution of absolute ethanol / acetone with a volume ratio of 1:1 to remove surface stains, and then air dry naturally after taking it out;

[0031] (2) Configure the electrolyte: mix Ca(NO 3 ) 2 4H 2 O, Zn(NO 3 ) 2 ·6H 2 O, NH 4 h 2 PO 4 and NaNO 3 Dissolved in water to prepare electrolyte, and the concentration of each component in the electrolyte is: Ca(NO 3 ) 2 4H 2 O40mmol / L, Zn(NO 3 ) 2 ·6H 2 O2mmol / L, NH 4 h 2 PO 4 28mmol / L, NaNO 3 0.1mol / L;

[00...

Embodiment 2

[0038] A method for preparing a coating for improving the corrosion resistance and biocompatibility of medical magnesium and magnesium alloys, comprising the following steps:

[0039] (1) Pretreatment of the base material: Cut the Mg-Zn-Y-Nd alloy to be treated into a rectangular block of 25mm×10mm×4mm, use it as the base material, use 100#, 200#, 400#, 600# Mechanically polish the surface with 800# metallographic sandpaper in sequence, and perform ultrasonic cleaning (frequency 40kHz) for 10 minutes in a mixed solution of absolute ethanol / acetone with a volume ratio of 1:1 to remove surface stains, and then air dry naturally after taking it out;

[0040] (2) Configure the electrolyte: mix Ca(NO 3 ) 2 , Zn(H 2 PO 4 ) 2 2H 2 O, NaH 2 PO 4 and NaNO 3 Dissolved in water to prepare electrolyte, and the concentration of each component in the electrolyte is: anhydrous Ca(NO 3 ) 2 30mmol / L, Zn(H 2 PO 4 ) 2 2H 2 O0.8mmol / L, NaH 2 PO 4 15mmol / L, NaNO 3 0.1mol / L;

[00...

Embodiment 3

[0045] A method for preparing a coating for improving the corrosion resistance and biocompatibility of medical magnesium and magnesium alloys, comprising the following steps:

[0046] (1) Pretreatment of the substrate material: Cut the AZ31 alloy to be processed into a rectangular block of 25mm×10mm×4mm, use it as the substrate material, and use 100#, 200#, 400#, 600# and 800# metallographic sandpaper The surface is mechanically polished in turn, and ultrasonically cleaned (frequency 40kHz) for 10 minutes in a mixed solution of absolute ethanol / acetone with a volume ratio of 1:1 to remove surface stains, and then air-dried naturally after taking it out;

[0047] (2) Configure the electrolyte: mix Ca(NO 3 ) 2 4H 2 O, Zn(NO 3 ) 2 ·6H 2 O, NaH 2 PO 4 and NaNO 3 Dissolved in water to prepare electrolyte, and the concentration of each component in the electrolyte is: Ca(NO 3 ) 2 4H 2 O50mmol / L, Zn(NO 3 ) 2 ·6H 2 O8mmol / L, NaH 2 PO 4 27mmol / L, NaNO 3 0.5mol / L.

[0...

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Abstract

The invention provides a coating capable of improving the surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloy and a preparing method of the coating. An electrolyte is composed of an aqueous solution containing Zn2+ salt, Ca2+ salt, H2PO4- salt and NaNO3. The zinc-calcium-phosphate-containing coating good in coverage is prepared on the surfaces of magnesium and magnesium alloy with the electrolyte through an electrochemical deposition method. The coating belongs to non-stoichiometric CaZn2(PO4)2.2H2O coatings, and has the significant advantages that degradation can be achieved while the corrosion resistance of a magnesium matrix is improved, and the degradability of the matrix cannot be changed by the coating. Meanwhile, Zn2+ can be released in the degrading process of the coating, differentiation of osteoblast can be promoted, the activity of osteoclast can be restrained, and thus the biocompatibility of the matrix is also improved. Thus, the coating has good application prospects when applied to magnesium alloy bone implanting medical instruments.

Description

technical field [0001] The invention belongs to the technical field of surface treatment of biomedical magnesium alloys, and in particular relates to a coating for improving the corrosion resistance and biocompatibility of medical magnesium and magnesium alloys and a preparation method thereof. Background technique [0002] Magnesium alloys are considered to be a promising biodegradable material for medical bone implants due to their biodegradability and elastic modulus similar to that of human bone. [0003] However, magnesium and magnesium alloys corrode too fast in the physiological environment of the human body, which cannot meet the needs of implantation well, and too fast corrosion will lead to Mg 2+ A large amount of accumulation has a certain toxic effect on surrounding cells. Therefore, improving the problem of high corrosion rate is a hot spot in the research of medical magnesium alloys. [0004] Surface modification technology is a solution to the problem of too...

Claims

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Application Information

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IPC IPC(8): C25D9/12
CPCC25D5/18C25D9/12C25D5/617A61L27/047A61L27/32A61L27/58A61L2420/02A61L2430/02C25D3/22C25D5/42
Inventor 关绍康梅迪冯雅珊朱世杰王俊王利国王艳华
Owner ZHENGZHOU UNIV
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