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Assistant hypoglycemic momordica grosvenori preparation and preparation method thereof

A Luo Han Guo, hypoglycemic technology, applied in the field of medicine, achieves the effects of inhibiting the rise of blood sugar, overcoming the trouble of suffering, and being convenient for transportation

Inactive Publication Date: 2016-05-25
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, there are no reports on the use of immature Luo Han Guo as a raw material to extract the total saponins of Luo Han Guo, and to prepare the total saponins to assist in lowering blood sugar.

Method used

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  • Assistant hypoglycemic momordica grosvenori preparation and preparation method thereof
  • Assistant hypoglycemic momordica grosvenori preparation and preparation method thereof
  • Assistant hypoglycemic momordica grosvenori preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of Luo Han Guo Oral Liquid for Auxiliary Hypoglycemia:

[0049] The Luo Han Guo oral liquid that assists in lowering blood sugar is first extracted from the dried immature Luo Han Guo fruit with a growth period of 30 days to obtain a dry powder with a total saponin weight content of 60% to 90%, and then the dry powder is made into an oral liquid. The following is the specific preparation method of the oral liquid.

[0050] The extraction method of the dry powder with a total saponin weight content of 60% to 90% is as follows: take the dried immature Luo Han Guo fruit with a growth period of 30 days, pulverize it, add pure water at a ratio of 1:1 by the weight of the medicinal material, until the sample is completely submerged So far, extract 1 time, extract time 10h, keep temperature at 40°C, combine filtrate and concentrate; after filtrate is extracted by n-butanol, add 1 times of filtrate volume n-butanol to filtrate and extract 3 times, use D101 macroporo...

Embodiment 2

[0055] Preparation of Luo Han Guo Oral Liquid for Auxiliary Hypoglycemia:

[0056] The Luo Han Guo oral liquid that assists in lowering blood sugar is first extracted from the dried immature Luo Han Guo fruit with a growth period of 60 days to obtain a dry powder with a total saponin weight content of 60% to 90%, and then the dry powder is made into an oral liquid. The following is the specific preparation method of the oral liquid.

[0057] The extraction method of the dry powder with a total saponin weight content of 60% to 90% is as follows: take the dried immature Luo Han Guo fruit with a growth period of 60 days, pulverize it, add pure water according to the weight of the medicinal material 1:8 times, until the sample is completely submerged So far, extract 2 times, 6h each time, keep the temperature at 60°C, combine the filtrate and concentrate; after the filtrate is extracted with n-butanol, add n-butanol twice the volume of the filtrate to the filtrate to extract twice...

Embodiment 3

[0062] Preparation of Luo Han Guo Oral Liquid for Auxiliary Hypoglycemia:

[0063] The Luo Han Guo oral liquid that assists in lowering blood sugar is first extracted from the dried immature Luo Han Guo fruit with a growth period of 80 days to obtain a dry powder with a total saponin weight content of 60% to 90%, and then the dry powder is made into an oral liquid. The following is the specific preparation method of the oral liquid.

[0064] The extraction method of the dry powder with a total saponin weight content of 60% to 90% is as follows: take the dried immature Luo Han Guo fruit with a growth period of 80 days, pulverize it, and add pure water at a ratio of 1:9 times the weight of the medicinal material until the sample is completely submerged. So far, extract 3 times, each extraction 2h, the temperature is kept at 90 ° C, the filtrate is combined and concentrated; after the filtrate is extracted with n-butanol, add n-butanol twice the volume of the filtrate to the filt...

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Abstract

The invention relates to an assistant hypoglycemic momordica grosvenori preparation, and particularly provides dry powder which is extracted from immature momordica grosvenori with a growing period of 30-80 days and of which the total saponin content is 60%-90%, and a preparation method of the dry powder in preparation of assistant hypoglycemic oral liquid, particle, capsule and tablet. The assistant hypoglycemic momordica grosvenori preparation is capable of reducing fasting blood-glucose of patients with impaired glucose tolerance and the patients with type 2 diabetes mellitus, and simultaneously is capable of obviously inhibiting blood glucose rise after the meal and relieving the degree of insulin resistance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Luo Han Guo preparation for assisting in lowering blood sugar and a preparation method thereof. Background technique [0002] Diabetes is a common and frequently-occurring disease, and its incidence has been on the rise in recent years. Due to the impact of persistent high levels of blood sugar, diabetic patients have various types of complications and eventually lead to death. At present, there are many kinds of oral hypoglycemic drugs for the treatment of diabetes, but the adverse reactions of most oral hypoglycemic drugs are more obvious after long-term use, and they cannot take into account the control of postprandial blood sugar and fasting basal blood sugar levels. Insulin sensitizers represented by thiazolidinones can significantly improve insulin resistance, but have no good control effect on the obvious increase in postprandial blood glucose levels, while ...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61P3/10
CPCA61K9/0053A61K9/08A61K9/1623A61K9/2059A61K9/4858A61K36/42A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 夏星王勤李宇清王志萍梁明坤
Owner GUANGXI UNIV OF CHINESE MEDICINE
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