New application of caesalpinia minax in preparation of medicines for treating alzheimer's disease

A new use, the technology of the rhododendron, which is applied in the preparation of the drug for the treatment of Alzheimer's disease, the new usage field of the alcohol extract of the rhododendron, and achieves the effects of simple process, low comprehensive cost and high safety.

Inactive Publication Date: 2016-05-04
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the treatment of Alzheimer's disease

Method used

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  • New application of caesalpinia minax in preparation of medicines for treating alzheimer's disease
  • New application of caesalpinia minax in preparation of medicines for treating alzheimer's disease
  • New application of caesalpinia minax in preparation of medicines for treating alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 10kg of Bougainvillea fruticosa and pulverize it, add 30% ethanol to extract twice, add 30% ethanol 15 times the weight of the medicinal material for the first time, soak for 30 minutes, heat and reflux for 2 hours, and add 30% ethanol 8 times the weight of the medicinal material for the second time Extract with % ethanol for 1 hour, combine the extracts, filter, concentrate the filtrate, and dry in vacuum to obtain the alcohol extract of Bougainvillea.

Embodiment 2

[0027] Take 10kg of Bougainvillea fruticosa and pulverize, add 50% ethanol to extract twice, first add 50% ethanol 8 times the weight of the medicinal material, soak for 30 minutes, heat and reflux for 2 hours, add 50% ethanol 6 times the weight of the medicinal material for the second time Extract with % ethanol for 1 hour, combine the extracts, filter, concentrate the filtrate, and dry in vacuum to obtain the ethanol extract.

Embodiment 3

[0029] Take 10kg of Bougainvillea fruticosa, grind it, add concentration and be 70% ethanol to extract twice, add 70% ethanol 10 times the weight of the medicinal material for the first time, soak for 30 minutes, heat and reflux for 1 hour, add 70% ethanol 8 times the weight of the medicinal material for the second time Extract with % ethanol for 1 hour, combine the extracts, filter, concentrate the filtrate, and dry in vacuum to obtain the alcohol extract of Bougainvillea.

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PUM

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Abstract

The invention relates to a new application of caesalpinia minax, namely a new application of caesalpinia minax in preparation of medicines for treating an alzheimer's disease, in particular to a new application of a caesalpinia minax extract in preparation of medicines for treating the alzheimer's disease. The learning ability and the memory of dementia mice treated by the caesalpinia minax extract are obviously improved; the clearance rate of oxygen radicals in the brain tissue is improved; and beta-starch amyloid protein is reduced. The caesalpinia minax has a protecting effect on nerve injuries of AD mice and has positive reference for development and research and clinical treatment of medicines for clinical treatment of elder diseases of the alzheimer's disease and the like.

Description

technical field [0001] The present invention relates to the new application of Bollia chinensis, especially the new application of the alcohol extract of Bollia chinensis, that is, the new application in the preparation of drugs for treating Alzheimer's disease. technical background [0002] Alzheimer's disease (AD) occurs in old age and pre-senile age, and is one of the most common types of senile dementia. It is a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and behavioral damage. For brain volume reduction and brain weight loss, brain sulcus deepening, widening, brain gyrus atrophy, temporal lobe especially hippocampus atrophy. Clinical manifestations include memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial abilities, impairment of abstract thinking and calculation, and changes in personality and behavior. The disease progresses slowly, symptoms of the pyramidal system and extrapyramidal sys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P25/28
CPCA61K36/48A61K2236/333A61K2236/39
Inventor 陈露刘冠萍吕林艳朱小凤
Owner GUANGXI WUZHOU PHARMA GRP
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