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A kind of green preparation method of modified chitosan-nanometer silver sol

A technology of nano-silver sol and chitosan, which is applied in metal processing equipment, transportation and packaging, etc., can solve the problems of poor water solubility and restrictions on the application of chitosan-nano-silver sol, and achieve strong antibacterial properties and stable dispersion , the effect of reducing cytotoxicity

Inactive Publication Date: 2017-08-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan has poor water solubility and can only play a stabilizing role in an acidic environment, while the environment of normal organisms is mostly neutral or weakly alkaline, which restricts the application of chitosan-nano silver sol in vivo

Method used

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  • A kind of green preparation method of modified chitosan-nanometer silver sol
  • A kind of green preparation method of modified chitosan-nanometer silver sol
  • A kind of green preparation method of modified chitosan-nanometer silver sol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Disperse the chitosan powder in deionized water, adjust the pH to 5.0, and prepare a chitosan aqueous solution with a mass concentration of 0.1%; add 3-(2,4-dihydroxy)phenyl in the chitosan aqueous solution Propionic acid (HCA), make its molar concentration be 30% of amino molar concentration in chitosan, then add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) As a catalyst, make its molar concentration 30% of the amino molar concentration in chitosan, react at 40°C for 12 hours to obtain an aqueous solution of modified chitosan, obtain modified chitosan after dialysis and freeze-drying;

[0026] 2) dissolving the modified chitosan obtained in the step 1) in deionized water, and being mixed with a modified chitosan aqueous solution whose mass concentration is 1%;

[0027] 3) dissolving silver nitrate in deionized water to prepare a silver nitrate aqueous solution with a mass concentration of 20%;

[0028] 4) Under dark conditions, take 1 mL of modi...

Embodiment 2

[0030] 1) Disperse the chitosan powder in deionized water, adjust the pH to 5.0, and prepare a chitosan aqueous solution with a mass concentration of 0.5%; add 3-(2,4-dihydroxy)phenyl in the chitosan aqueous solution Propionic acid (HCA), make its molar concentration be 40% of amino molar concentration in chitosan, then add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) As a catalyst, make its molar concentration 40% of the molar concentration of amino groups in chitosan, react at 40°C for 18 hours to obtain an aqueous solution of modified chitosan, obtain modified chitosan after dialysis and freeze-drying;

[0031] 2) the modified chitosan obtained in the step 1) is dissolved in deionized water, and is mixed with a modified chitosan aqueous solution whose mass concentration is 3%;

[0032] 3) dissolving silver nitrate in deionized water to prepare a silver nitrate aqueous solution with a mass concentration of 30%;

[0033] 4) Under the condition of avoiding...

Embodiment 3

[0035] 1) Disperse the chitosan powder in deionized water, adjust the pH to 5.0, and prepare a chitosan aqueous solution with a mass concentration of 1%; add 3-(2,4-dihydroxy)phenyl in the chitosan aqueous solution Propionic acid (HCA), make its molar concentration be 60% of amino molar concentration in chitosan, then add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) As a catalyst, make its molar concentration 60% of the molar concentration of amino groups in chitosan, react at 30°C for 24 hours to obtain an aqueous solution of modified chitosan, obtain modified chitosan after dialysis and freeze-drying;

[0036] 2) the modified chitosan obtained in the step 1) is dissolved in deionized water, and is mixed with a modified chitosan aqueous solution whose mass concentration is 5%;

[0037] 3) dissolving silver nitrate in deionized water to prepare a silver nitrate aqueous solution with a mass concentration of 50%;

[0038] 4) Under dark conditions, take 5 mL ...

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Abstract

The invention discloses a green preparation method of modified chitosan-nanometer silver sol. In the method, catechol groups are grafted onto chitosan through amidation reaction to prepare modified chitosan. Utilizing the reduction of catechol groups and the chelating effect of chitosan, the modified chitosan was used as a reducing agent and a stabilizer, and reacted with silver nitrate solution to prepare modified chitosan-nano-silver sol. The sol prepared by the invention has the advantages of narrow particle size distribution, difficult agglomeration, high stability and the like. The synergistic antibacterial effect of chitosan and nano-silver makes the composite nano-silver exhibit strong antibacterial properties. Due to the good biocompatibility of chitosan, the biological toxicity of the encapsulated nano-silver is greatly reduced, and it has great application prospects in the field of biomedicine. The preparation method does not need an external reducing agent, has wide source of raw materials, simple process, mild reaction, and meets the requirements of green chemistry.

Description

technical field [0001] The invention belongs to the field of preparation of nano-silver antibacterial composite materials, and relates to a preparation method of sol, in particular to a green preparation method of modified chitosan-nano-silver sol. Background technique [0002] Nanomaterials refer to particles with at least one dimension between 1 and 100nm in size. Due to their unique properties and potential application prospects, nanotechnology has also become a research hotspot, setting off a wave in various research fields. upsurge. Among many nanomaterials, nanosilver has become the focus of scientists' research because of its special physical and chemical properties, and its potential application value in the fields of antibacterial, catalysis, medicine, and biosensors. In the field of antibacterial materials, nano-silver has attracted the attention of researchers at home and abroad because of its high-efficiency bactericidal properties and broad-spectrum antibacteri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24
CPCB22F9/24B22F1/0545
Inventor 王征科黄晓飞胡巧玲
Owner ZHEJIANG UNIV
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