Polycaprolactone silk fibroin electrospun fiber membrane with continuous lamellar micro-nano structure on the surface and its preparation method and application

Abstract

The invention discloses a polycaprolactone and silk fibroin electrospun fibrous membrane with the surface of a continuous laminated micro-nano structure and a preparation method and application thereof. The preparation method comprises the steps that 1, silk fibroin and polycaprolactone are dissolved into hexafluoroisopropanol and are stirred and dissolved at room temperature to obtain a mixed solution; 2, electrostatic spinning is performed on the mixed solution to prepare a polycaprolactone and silk fibroin blended membrane; 3, vacuum drying is performed on the polycaprolactone and silk fibroin blended membrane, then, the polycaprolactone and silk fibroin blended membrane is subjected to a heating reaction with a PCL monomer and a stannous octoate catalyst under the nitrogen protection, and the polycaprolactone and silk fibroin electrospun fibrous membrane is obtained. The polycaprolactone and silk fibroin electrospun fibrous membrane obtained through the preparation method has the surface layer laminated micro-nano structure fiber morphology, the specific surface area and the fiber diameter are greatly increased, the probability that the hydrophobicity of the electrospun membrane is converted into hydrophile is increased, the fiber specific surface area is greatly increased, and the space maintaining capacity, the dynamic mechanics performance and the degradation performance are greatly improved.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a polycaprolactone silk fibroin electrospun fiber membrane with a continuous lamellar micro-nano structure on the surface, a preparation method and application thereof. Background technique [0002] After realizing the importance of guided tissue regeneration membrane technology, polytetrafluoroethylene membrane (ePTFE) was first used in the research field of guided bone regeneration, but there were a series of complications during the use of ePTFE membrane, and a second operation was required to remove it . The absorbable membrane can control the degradation rate, without the need for secondary surgery to remove it, which is convenient for the operator to operate, reduces the pain of the patient, shortens the healing period, and reduces complications such as membrane exposure and infection. A large number of animal experiments have studied the applicatio...

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Problems solved by technology

[0004] Although the polycaprolactone protein blended membrane has most of the advantages of absorbable membranes, due to the influence of the preparation process, the molecular weight is much lower than before the preparation, resulting in poor mechanical properties and degradation ability, which has become the largest biomedical application. hinder

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