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A kind of preparation method of double-layer structure corneal repair material

A repair material and a double-layer structure technology, applied in the fields of medical devices, cosmetics, and biomedical materials, can solve problems such as poor mechanical properties, difficulty in shaping, and inability to support tissue reconstruction, and achieve high production efficiency, simple preparation process, and good The effect of light transmission

Active Publication Date: 2019-03-05
GUANGZHOU PUDAO LIANXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pure collagen matrix has the advantages of good biocompatibility, easy processing, and the ability to promote cell proliferation and differentiation, but it also has defects such as poor mechanical properties, difficulty in shaping when it contains water, and inability to support tissue reconstruction.

Method used

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  • A kind of preparation method of double-layer structure corneal repair material
  • A kind of preparation method of double-layer structure corneal repair material
  • A kind of preparation method of double-layer structure corneal repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1 g of PVA with a molecular weight of 13000-23000 was added to 10 ml of deionized water, and stirred in a constant temperature oil bath at 95° C. for 2 hours to obtain a PVA solution. Leave to stand at room temperature, pour into a glass mold, and dry naturally to form a film at room temperature. Use 0.3wt% acetic acid solution to prepare 100ml of 0.5wt% collagen solution; after fully stirring, spread the collagen solution evenly, dry and shape to obtain a PVA / collagen double-layer film. The material of the mold is glass mold, and the surface of the prepared composite film is relatively rough ( figure 1 Middle a).

Embodiment 2

[0031] Add 0.5 g of PVA with a molecular weight of 13,000-23,000 into 10 ml of deionized water, and stir in a constant temperature oil bath at 95° C. for 2 hours to obtain a PVA solution. Leave to stand at room temperature, pour into a polytetrafluoroethylene mold, and dry naturally to form a film at room temperature. Use 0.3wt% acetic acid solution to prepare 10ml of 0.5wt% collagen solution; after fully stirring, spread the collagen solution evenly on the surface of the PVA film, dry and form it to obtain a PVA / collagen double-layer film. The surface of the composite membrane made by using the polytetrafluoroethylene mold is relatively flat and smooth ( figure 1 Middle b), and the corneal repair effect of animal experiments is good ( Figure 4 ).

Embodiment 3

[0033] 1 g of PVA with a molecular weight of 13000-23000 was added to 10 ml of deionized water, and stirred in a constant temperature oil bath at 95° C. for 2 hours to obtain a PVA solution. Leave to stand at room temperature, pour into a mold made of PMMA material, and dry naturally to form a film at room temperature. Use 0.3wt% acetic acid solution to prepare 10ml of 0.5wt% collagen solution; after fully stirring, spread the collagen solution evenly on the surface of the PVA film, dry and form it to obtain a PVA / collagen double-layer film. The composite film surface that uses PMMA mold to make is all different from above-mentioned glass mold and polytetrafluoroethylene mold ( figure 1 Middle c).

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Abstract

The invention discloses a preparation method of a cornea repair material of a double-layer structure, and relates to the related fields of biomedical materials, medical apparatuses and instruments, cosmetics and the like. The method includes the following steps of dissolving collagen in weak acid to obtain a collagen solution of a certain concentration, preparing polyvinyl alcohol (PVA) into a solution, pouring the solution into a mold, conducting drying forming to obtain a polyvinyl alcohol film, laying the collagen solution on the surface of the polyvinyl alcohol membrane flat, and conducting drying to obtain a collagen compound membrane. The obtained compound membrane solves the problem that an existing collagen material is not enough in mechanical strength, and can promote adherency and proliferation of cells, and a new way is provided for application of collagen. The preparation method is simple in preparation process, high in repeatability and suitable for industrialized large-scale production of modified collagen compound films with different requirements.

Description

technical field [0001] The invention relates to the related fields of biomedical materials, medical devices and cosmetics, in particular to a preparation method of a polyvinyl alcohol-reinforced collagen composite film, which is used in the fields of promoting epithelialization of corneal tissue, soft tissue patches, wound dressings and facial masks. Background technique [0002] Collagen is the main component of the extracellular matrix, which accounts for about 25-35% of the total body protein in the human body. It mainly exists in connective tissue and is the most abundant structural protein in the human body. High collagen content can provide a good growth environment for cells and promote cell proliferation and differentiation. Collagen has good biocompatibility, nutrition, moisture retention and degradability, and is widely used in functional products such as biomedical materials, cosmetics and food. [0003] The eye is the window to the soul. It is a rather complex n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/32A61L27/16A61L27/22A61L27/26A61K8/02A61Q19/00
CPCA61K8/02A61L15/24A61L15/325A61L27/16A61L27/222A61L27/26A61L2430/16A61Q19/00C08L29/04
Inventor 任力李卫昌王迎军
Owner GUANGZHOU PUDAO LIANXIN BIOTECH CO LTD
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