Dexmethylphenidate skeleton pattern transdermal patch containing vitiligo inhibitor and preparing method and application thereof

Abstract

The invention discloses a dexmethylphenidate skeleton pattern transdermal patch containing a vitiligo inhibitor and a preparing method thereof. The transdermal patch comprises a skeleton pattern adhesive layer, wherein the skeleton pattern adhesive layer comprises dexmethylphenidate or hydrochloride thereof, the vitiligo inhibitor and an adhesive, the vitiligo inhibitor contains one or more of titanium dioxide, tartaric acid, tretinoin, trichloroacetic acid, zinc oxide, hydroxyl dimethoxy phenylmalonate diethyl hexyl ester and ectoin, and the weight ratio of the vitiligo inhibitor is 5-15%. By the adoption of the transdermal patch, curative effect is guaranteed, and perpetual skin vitiligos are prevented from being generated; the efficacy of the preparation is improved, children clinical medication risks are reduced, and the safety of the preparation is fully guaranteed. The transdermal patch is simple in composition, the technology is simple and easy to apply, cost is low, and production is highly efficient.

Description

technical field [0001] The present invention relates to dexmethylphenidate skeleton type transdermal patch, preparation method and application thereof Background technique [0002] Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder in childhood, mainly manifested as obvious attentional disorientation and short attention span, hyperactivity, impulsive behavior accompanied by learning difficulties and conduct disorders. The incidence rate of children is higher, and the reported ADHD rate in my country is 1.3% to 13.4%. It not only affects children's life at school and at home, but also easily causes learning difficulties and behavioral problems, some of which persist for life. Some or even all of the symptoms of inattention and impulsivity may remain after adulthood, and there may be more social function problems, such as difficulty in work, poor interpersonal communication, low self-evaluation, impulsivity, irritability, etc.; obvious mental prob...

AI Technical Summary

Problems solved by technology

[0005] Chinese patents CN102160857A and US20000618626 disclose methylphenidate patches, which are superior in the stability of the drug in the patch and skin permeability, but the pharmacological activity of the L-isomer in methylphenidate is low, which affects the overall curative effect. , can cause permanent white spots on the skin

In addition, the polyisobutylene in the CN102160857A prescription needs to be used in combination with more harmful solvents such as toluene and gasoline, which is harmful to the environment and human health

Chinese patent CN101683342A discloses a freeze-dried powder preparation of dexmethylphenidate and its preparation process. The obtained preparation has good stability and rapid onset of action, but children have poor compliance with injection administration, high safety risks, and cannot achieve long-lasting Efficacy

Patent CN101933913A discloses a double-release preparation of dexmethylphenidate hydrochloride and its preparation method. Compared with common preparations, it reduces the number of daily doses, but the bioavailability of oral dexmethylphenidate is low and the side effects are more obvious

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