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Well-being rhinitis tablets and preparing method thereof

A technology for chronic rhinitis and allergic rhinitis, applied in the field of Kangle rhinitis tablet and its preparation, can solve the problems of slow disintegration, unsatisfactory curative effect, low curative effect and the like

Inactive Publication Date: 2016-02-24
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the composition and process of Kangle Biyan Tablets, the curative effect is not ideal. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Well-being rhinitis tablets and preparing method thereof
  • Well-being rhinitis tablets and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 280g of Tribulus terrestris, 198g of Gansong, 56g of Gallus gallus domesticus, 750g of cocklebur, 280g of Angelica dahurica, 250g of Ephedra, Andrographis 780g, scutellaria 280g, 395g of parsnip, 500g of patchouli, crushed into 60 mesh coarse powder, using supercritical carbon dioxide extraction Method extraction, extraction pressure 20Mpa, extraction temperature 21°C, separator pressure 12Mpa, separator temperature 36°C, separation time 1.7 hours, carbon dioxide flow rate 22L per hour, to obtain the extract; take the extract to 65°C and dry under reduced pressure to obtain a dry paste ; Take the dry paste and add 80g of citric acid, use high-energy nano-impact mill to crush into a mixed dry paste powder with a particle size of 200 ~ 300nm; take the mixed dry paste powder, microcrystalline cellulose 35g, hydroxypropyl cellulose 35g, croscarmellose Base cellulose sodium 35g, magnesium aluminum silicate 15g, sodium chloride 5g, mannitol 4g, maltodextrin 4g, mix well, u...

specific Embodiment 2

[0034] Take 280g of Tribulus terrestris, 198g of Gansong, 56g of Gallus gallus domesticus, 750g of cocklebur, 280g of Angelica dahurica, 250g of Ephedra, Andrographis 780g, scutellaria 280g, 395g of parsnip, 500g of patchouli, crushed into 60 mesh coarse powder, using supercritical carbon dioxide extraction Method extraction, extraction pressure 42Mpa, extraction temperature 45°C, separator pressure 19Mpa, separator temperature 53°C, separation time 3.6 hours, carbon dioxide flow rate 37L per hour, to obtain the extract; take the extract to 79°C and dry under reduced pressure to obtain a dry paste ; Take the dry paste and add 120g of citric acid, use high-energy nano impact mill to crush into a mixed dry paste powder with a particle size of 200 ~ 300nm; take the mixed dry paste powder, microcrystalline cellulose 45g, hydroxypropyl cellulose 45g, croscarmellose Base cellulose sodium 45g, magnesium aluminum silicate 25g, sodium chloride 15g, mannitol 6g, maltodextrin 6g, mix well,...

Embodiment 3

[0036] Take 280g of Tribulus terrestris, 198g of Gansong, 56g of Gallus gallus domesticus, 750g of cocklebur, 280g of Angelica dahurica, 250g of Ephedra, Andrographis 780g, scutellaria 280g, 395g of parsnip, 500g of patchouli, crushed into 60 mesh coarse powder, using supercritical carbon dioxide extraction Extraction method, extraction pressure 31Mpa, extraction temperature 33°C, separator pressure 16Mpa, separator temperature 45°C, separation time 2.7 hours, carbon dioxide flow rate 30L per hour, to obtain an extract; take the extract to 72°C and dry under reduced pressure to obtain a dry paste ; Take the dry paste and add 100g of citric acid, use high-energy nano impact mill to pulverize into a mixed dry paste powder with a particle size of 200 ~ 300nm; take the mixed dry paste powder, microcrystalline cellulose 40g, hydroxypropyl cellulose 40g, croscarmellose Base cellulose sodium 40g, magnesium aluminum silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix we...

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Abstract

The invention discloses well-being rhinitis tablets and a preparing method thereof. The well-being rhinitis tablets and the preparing method thereof are characterized in that 280 g of caltrop, 198 g of rhizoma nardostachyos, 56 g of endothelium corneum gigeriae galli, 750 g of cocklebur fruits, 280 g of radix angelicae, 250 g of ephedra, 780 g of common andrographis herb, 280 g of scutellaria baicalensis, 395 g of saposhnicovia divaricata and 500 g of pogostemon cablin are taken, extracted through a carbon dioxide supercritical fluid extraction method, dried under reduced pressure, and ground by a high-energy nanometer impact mill to obtain nanometer dry paste, and the nanometer dry paste is added with functional auxiliary materials to be prepared into the well-being rhinitis tablets. The disintegration time is obviously shortened, the curative effect is much better than that of well-being rhinitis tablets sold in the market, and positive effects are achieved.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Kangle rhinitis tablet and a preparation method thereof. Background technique [0002] Kangle Rhinitis Tablets disperses wind and heat, promotes blood circulation and removes blood stasis, dispels dampness and relieves orifices. It is used for cold and nasal congestion, nasal choking, allergic rhinitis, rhinitis (acute and chronic rhinitis, allergic rhinitis, sinusitis) caused by exogenous wind evil, gall bladder stagnation heat, spleen and stomach damp heat. The commercially available Kangle rhinitis tablets have poor curative effect due to the composition and process. The preparations are prepared by traditional techniques, which have the disadvantages of slow disintegration and low curative effect. Summary of the invention [0003] To overcome the above shortcomings, the present invention provides a Kangle rhinitis tablet with fast disintegration speed and high curativ...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61P11/02A61P37/08A61K35/57
CPCA61K36/185A61K9/2009A61K9/2013A61K9/2018A61K9/205A61K9/2054A61K9/2059A61K35/57A61K36/17A61K36/19A61K36/232A61K36/238A61K36/28A61K36/53A61K36/539A61K2236/37A61K2236/51
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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