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Preparation method of high-flexibility amphoteric ionic hydrogel

A zwitterionic and hydrogel technology, applied in the field of highly flexible zwitterionic hydrogel, can solve the problems of not being widely used, poor mechanical properties, complicated methods, etc., and achieve easy promotion, good flexibility, and preparation The effect of simple method

Active Publication Date: 2016-02-03
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, under normal circumstances, the prepared zwitterionic hydrogels often have poor mechanical properties and are brittle due to their superhydrophilic properties leading to excessive water content, which limits the application of this material in some medical materials that require certain mechanical requirements. Applications, such as artificial joints, artificial organs, artificial blood vessels and other orthopedic and vascular and cardiac tissue engineering
[0003] Therefore, many research groups improve the mechanical properties of zwitterionic hydrogels by changing the skeleton structure of zwitterionic monomers, changing the structure of crosslinking agents, or introducing some monomers with strong mechanical properties. However, these methods are relatively complicated and therefore not widely used

Method used

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  • Preparation method of high-flexibility amphoteric ionic hydrogel
  • Preparation method of high-flexibility amphoteric ionic hydrogel
  • Preparation method of high-flexibility amphoteric ionic hydrogel

Examples

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example 1

[0017] Example 1: At room temperature (preferably 25°C), the monomer [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) 1.4g Add 0.0014g of polyethylene glycol dimethacrylate (PEGDMA, molecular weight 550, 0.1% relative to the mass ratio of monomer SBMA) into a 5ml centrifuge tube, and dissolve the monomer and crosslinker with 1ml of deionized water Finally, add 0.014g of photoinitiator 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure2959, the quality of the initiator is 1% of the monomer) and wrap it with tin foil to avoid light deal with. The mixed solution containing monomer, crosslinking agent and initiator was injected into the sealed mold, and the mold was irradiated in a UV curing light box (RSV-2000, Tianjin Ruisent Ultraviolet Equipment Co., Ltd.) for 10 minutes to fully initiate free radical polymerization. Then the mold was repeatedly rinsed with deionized water several times. For the first three days, the water was changed ev...

example 2

[0018] Example 2: At room temperature (preferably 25°C), the monomer [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) 1.4g Add cross-linking agent polyethylene glycol dimethacrylate 0.0007 (PEGDMA, molecular weight 330, relative monomer mass ratio 0.05%, sigma) into a 5ml centrifuge tube, dissolve monomer and cross-linking agent with 1ml deionized water Finally, 0.014 g of photoinitiator 2-hydroxyl-4'-(2-hydroxyethoxyl)-2-methylpropiophenone was added, wrapped with tin foil and protected from light. The mixed solution containing monomer, crosslinking agent and initiator was injected into the sealed mold, and the mold was irradiated for 30 minutes in a UV curing light box (RSV-2000 from Tianjin Ruisent Ultraviolet Equipment Co., Ltd.) to fully initiate free radical polymerization. Then the mold was repeatedly rinsed with deionized water several times. For the first three days, the water was changed every 3-5 hours, soaked for 8 days, and the above dei...

example 3

[0019] Example 3: At room temperature (preferably 25°C), the monomer [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) (1.4 g, sigma company) and cross-linking agent polyethylene glycol dimethacrylate 0.007g (PEGDMA, molecular weight 2000, relative monomer mass ratio 0.5%, sigma) were added to a 5ml centrifuge tube and dissolved in 1ml deionized water After monomer and linking agent, add photoinitiator 2-hydroxyl-4 '-(2-hydroxyethoxy)-2-methyl propiophenone 0.014g (Irgacure2959, sigma, the quality of initiator is the monomer quality 1%) wrapped in tin foil to avoid light. The mixed solution containing monomer, crosslinking agent and initiator was injected into the sealed mold, and the mold was irradiated for 30 minutes in a UV curing light box (RSV-2000 from Tianjin Ruisent Ultraviolet Equipment Co., Ltd.) to fully initiate free radical polymerization. Then the mold was repeatedly rinsed with deionized water several times. For the first three days, t...

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Abstract

The invention discloses a preparation method of high-flexibility amphoteric ionic hydrogel. By changing the concentration of [2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide monomers, cross-linking agents and initiators, the high-flexibility amphoteric ionic SBMA hydrogel is obtained. The SBMA hydrogel prepared through the method has good mechanical property, protein adsorption resistance and cell adsorption performance through interaction of a large number of positive and negative charges of SB units, and meanwhile thermosensitivity and saline ion responding performance and self-restoration performance are achieved. Application of hydrogel based on amphoteric ions in the field of biomedical tissue engineering can be further expanded, and particularly in the fields, where certain mechanical strength is needed, such as artificial joints, blood vessels and the like. At the same time, the preparation method avoids the situation that traditionally, an amphoteric ionic SBMA main chain is modified through grafting, operation is easier, and industrialization of the whole process is easy.

Description

technical field [0001] The invention relates to a highly flexible zwitterionic hydrogel which is used for biomedical materials and has anti-protein non-specific adsorption and a preparation method thereof. Background technique [0002] A very important challenge in the field of biomaterials is the problem of nonspecific protein adsorption on material surfaces. In most cases, non-specific adsorption of proteins initiates many undesirable biological cascades. For example, for blood-contact materials, when blood first contacts foreign substances, plasma proteins will be adsorbed to the surface of the material in a short time, forming a layer of biomolecular adsorption layer, which will cause the adsorption of a large number of platelets, and the adsorption of platelets has no effect on the thrombus. Formation plays a decisive role, ultimately leading to a reduction in the hemocompatibility of the material. Therefore, the use of anti-protein non-specific adsorption materials f...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F228/02C08F220/28C08F2/48
Inventor 吴疆陈圣福肖健张宏宇李校堃肖泽聪何超超刘彦隆
Owner WENZHOU MEDICAL UNIV
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