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Method for preparing chemical crosslinking and metal ion complexing type interpenetrating network hydrogel

A technology of interpenetrating networks and metal ions, applied in the field of polymers, can solve problems such as weak biocompatibility, poor mechanical properties, and limit the application prospects of new materials, and achieve the effect of improving degradability and improving electrical conductivity

Active Publication Date: 2016-01-20
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional hydrogels have disadvantages such as poor mechanical properties, weak biocompatibility, and slow response, which limit their application prospects as new materials.

Method used

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  • Method for preparing chemical crosslinking and metal ion complexing type interpenetrating network hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Synthesis of polyethylene glycol derivatives containing dopamine (PEG(DA))z: Accurately weigh 1.9g of dopamine hydrochloride and dissolve it in 6mL of pyridine solution, react at room temperature for 0.5h in a nitrogen atmosphere, and then accurately weigh 5 g of polyethylene glycol derivatives with epoxy groups at both ends (Mn=500) were added to the reaction system, and the temperature was raised to 60° C. for 10 days in a nitrogen atmosphere. After the completion of the reaction, the reactants were precipitated in ether for several times, quickly rinsed with distilled water, vacuum-dried overnight after suction filtration, and polyethylene glycol derivatives containing multiple dopamines with different molecular weights were obtained.

[0027] Synthesis of polyethylene glycol derivatives (PEG(C≡CH))x containing three or more polyalkyne groups: the two-terminal epoxy polyethylene glycol derivatives (Mn=500) and propargylamine Carry out amino-epoxy polymerization react...

Embodiment 2

[0035] The basic process is the same as in Example 1, the difference is that:

[0036] In step 1), the polyethylene glycol derivative (Mn=2000) of azido groups at both ends is 0.3g (0.15mmol), 0.15g (0.015mmol) polyalkyne polyethylene glycol derivative (Mn=10000) , 0.128g (0.03mmol) polyethylene glycol derivatives (Mn=4200) containing multiple dopamines were ultrasonically oscillated at 50°C until completely dissolved, and the catalyst cuprous chloride (0.03mg, 0.0003mmol) was added rapidly, and the ligand N,N,N',N",N"-pentamethyldiethylenetriamine ligand (0.0003 mmol).

[0037] In step 2), the reaction temperature is 80° C., and the reaction time is 3 hours to form a hydrophilic semi-interpenetrating network hydrogel.

[0038] In step 3), the hydrophilic semi-IPN hydrogel is soaked in 0.01 mol / L zinc chloride solution for 2 hours to obtain the hydrophilic interpenetrating network hydrogel.

[0039] The rest are completely consistent with Example 1.

Embodiment 3

[0041] The basic process is the same as in Example 1, the difference is that:

[0042] In step 1), the polyethylene glycol derivatives (Mn=2000) of azido groups at both ends are 0.30g (0.15mmol), 0.15g (0.0075mmol) polyalkyne polyethylene glycol derivatives (Mn=20000) , 0.0768g (0.018mmol) polyethylene glycol derivatives (Mn=4200) containing multiple dopamines were ultrasonically shaken at 60°C until completely dissolved, and the catalyst cuprous bromide (0.143mg, 0.001mmol) was added rapidly, and the ligand 1,1,4,7,10,10-Hexamethyltriethylenetetramine and tris(N,N-dimethylaminoethyl)amine (0.0003 mmol).

[0043] In step 2), the reaction temperature is 90° C., and the reaction time is 2 hours to form a hydrophilic semi-IPN hydrogel.

[0044] In step 3), the hydrophilic semi-IPN hydrogel is soaked in 0.01 mol / L copper chloride solution for 3 hours to obtain the hydrophilic interpenetrating network hydrogel.

[0045] The rest are completely consistent with Example 1.

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Abstract

The invention discloses a method for preparing chemical crosslinking and metal ion complexing type interpenetrating network hydrogel. The hydrogel is a multiphase continuous hydrogel formed through interpenetrating and entanglement of two networks. According to the method, the positions and number of polymer chain connection points are controlled through amido-epoxy polymerization reaction, and a first polymerized network structure is prepared by means of click chemical reaction. Dopamine is high in cytocompatibility, biocompatibility and other properties. A polymer is prepared through dopamine-epoxy polymerization reaction, and the interpenetrating network hydrogel with various excellent properties is prepared through combination of ion complex reaction of the phenolic hydroxyl group in dopamine and the first polymerized network structure. The method is easy, and the obtained interpenetrating network hydrogel has the advantages of being high in elasticity, intensity and conductivity and wide in application range.

Description

technical field [0001] The invention belongs to the field of macromolecules, and relates to a preparation method of an interpenetrating network hydrogel which utilizes click chemistry and metal ion complexation in combination with chemical crosslinking and metal ion complexation. Background technique [0002] Polymer hydrogel material refers to a material with a low cross-linking degree that can quickly absorb and maintain a large amount of water and is insoluble in water. It has the characteristics of a polymer electrolyte and a three-dimensional network structure. And the rapid development of functional polymer materials. The superior properties of polymer hydrogel materials (such as high similarity with human tissue, biocompatibility, and high permeability to nutrients and metabolites, etc.) have attracted great interest and attention from many researchers. , Its application has penetrated into various fields such as agriculture, forestry, animal husbandry, biomedicine, ...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08J9/28C08L71/00C08G65/333
Inventor 付国东董孟姣姚芳
Owner SOUTHEAST UNIV
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