Anticoagulation method for surface of medical polymer material or product

A technology of polymer materials and products, which is applied in the field of anticoagulation technology, can solve the problems that are not suitable for widespread promotion, short anticoagulation time, and difficult to produce, and achieve the effects of prolonging the curing time, firm adsorption, and easy operation

Active Publication Date: 2015-12-30
天津协和生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing heparinized anticoagulant materials, on the one hand, are complicated and difficult to produce, and the cost is high, so they are not suitable for widespread promotion; Coagulant materials can only be used for anticoagulant materials with short operation times such as plasma component collection and hemodialysis, but for situations that need to be left in the body for a long time, such as deep vein indwelling catheters for tumor chemotherapy, it cannot meet the needs, so it is necessary to explore the conditions , to prolong the anticoagulation time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0023] Embodiment 1: the anticoagulation method of medical polymer material or product surface, comprises the following steps:

[0024] (1) Preparation of heparin-benzalkonium bromide complex:

[0025] 1) Dissolve 0.1g of heparin sodium in 10ml of purified water or distilled water;

[0026] 2) the benzalkonium bromide solution is made into a concentration of 5% (ml / ml) with purified water;

[0027] 3) 5% benzalkonium bromide solution was gradually added dropwise to the above sodium heparin solution until white precipitated suspension appeared. Continue to react for 5 minutes to make it fully react and the white precipitate and solution layering are obvious.

[0028] 4) Filter again with a G2 funnel to obtain a white precipitate. The white precipitate is fully washed and soaked with purified water or distilled water, and washed repeatedly until the white precipitate begins to form agglomerates and no quaternary ammonium salt remains, and a white or light yellow heparin compl...

Embodiment 2

[0037] Embodiment 2: Coating and curing medical polycarbonate (PC) tube:

[0038] 1) Preparation of coating solution:

[0039] Dissolve 10 g of the heparin quaternary ammonium salt complex described in step (1) of Example 1 in 40 ml of methanol and 60 ml of dichloroethane solution, and obtain a colorless and transparent coating solution after fully dissolving.

[0040] 2) Coating:

[0041] Pour the prepared coating solution into a medical PC tube in a 100-level environment, soak for 3 hours to form a stable heparin coating on the surface, take it out, and let it dry naturally.

[0042] 3) Curing treatment:

[0043] ① Prepare the curing agent bifunctional group reagent glutaraldehyde with purified water to a concentration of 1% (ml / ml).

[0044] ②Soak the above-coated medical PC tube in the bifunctional group reagent, and cure it at 60°C for 100 minutes to form a cross-linked heparin polymer coating. Finally, the unreacted bifunctional group reagent was cleaned with purified ...

Embodiment 3

[0045] Embodiment 3: Coating and curing medical silicone rubber (SR) tube:

[0046] 1) Preparation of coating solution:

[0047] Dissolve 1 g of the heparin quaternary ammonium salt complex described in step (1) of Example 1 in 100 ml of chloroform solution, and obtain a colorless and transparent coating liquid after fully dissolving.

[0048] 2) Coating:

[0049] In a 100-level purification environment, apply the prepared coating solution on the surface of the medical SR tube by a combination of flow-through and immersion methods, take it out after 40 minutes, let it dry naturally or blow dry, and return it after 1 to 5 hours. Apply the same method again to form a stable heparin coating on the surface of the medical SR tube and let it dry naturally.

[0050] 3) Curing treatment:

[0051] ① Prepare the curing agent bifunctional group reagent glutaraldehyde with purified water to a concentration of 0.5% (ml / ml).

[0052] ②Soak the above-coated medical SR tube in the bifunct...

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PUM

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Abstract

The invention discloses an anticoagulation method for the surface of a medical polymer material or product. The method comprises the following steps of 1, preparing a heparin complex, 2, preparing a coating solution, 3, conducting coating and 4 conducting curing treatment. The method is characterized in that in the fourth step, the surface, making contact with blood, of the medical polymer material is soaked in a difunctional group curing agent to be cured at the temperature of 30-60 DEG C, and the curing time is 60-100 min. The process technology is simple to implement, environmentally friendly, safe, low in cost and suitable for amplification and large-scale production. After coating is performed through the technology, the physical and chemical properties of the coated material are not affected, and the anticoagulation performance of the surface of the obtained material is good and is kept stable.

Description

(1) Technical field: [0001] The invention relates to an anticoagulation technology on the surface of medical polymer materials or products. (two) background technology: [0002] Medical materials and devices in contact with blood, such as artificial blood vessels, artificial hearts, artificial lungs, guide wires for mediated therapy, stent catheters, catheters, shunt arteriovenous pressure measuring tubes, etc., have been widely used in modern medicine. These materials and devices are usually mainly made of polymer materials, which themselves do not have anticoagulant properties or the anticoagulant time has not yet been used. When the blood comes into contact with it, a series of physiological reactions will occur, such as the adsorption and activation of platelets, the activation of complement, the activation of the exogenous coagulation system, etc., which will eventually lead to the formation of microemboli or thrombus. Therefore, when using it, the whole body of the pa...

Claims

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Application Information

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IPC IPC(8): A61L33/10C08B37/10
Inventor 杨成民徐开云童衍传郭旭光刘国庆梁伟光李燊李凤娟
Owner 天津协和生物科技发展有限公司
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