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Cyclophosphamide containing composition and application thereof in preparation of anti-breast-cancer drug

An anti-breast cancer and cyclophosphamide technology, which is applied in the field of medicine, can solve the problems of large genetic variation, long cycle, and unknown side effects of individual tumors, and achieve obvious tumor suppression effects, reduced toxic and side effects, and increased sensitivity

Inactive Publication Date: 2015-12-30
张德芳
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. characteristics, resulting in poor efficacy of many traditional antineoplastic drugs, as well as expensive new drugs with unknown side effects

Method used

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  • Cyclophosphamide containing composition and application thereof in preparation of anti-breast-cancer drug
  • Cyclophosphamide containing composition and application thereof in preparation of anti-breast-cancer drug

Examples

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Embodiment 1

[0016] Example 1: Study on the Curative Effect of Drugs on Breast Cancer Transplanted Tumors

[0017] BALB / c mice, female, with a body weight of 18-22 g. Take the 4T1 breast cancer tissue of mice inoculated with the 4T1 breast cancer tumor strain for 2 weeks and grow well, and grind it with normal saline to prepare 5×10 6 cells / ml suspension, inoculated under the fat pad of the second mammary of 32 female BALB / c mice with 0.1ml / only. One week after the inoculation, the mice were divided into 4 groups by body weight, 8 in every group, i.e. the model control group: intragastric administration of normal saline twice a day; Zolpidem group: intragastric administration of Zolpidem tartrate 1 mg / kg body weight every day, 2 Time / d; cyclophosphamide group: intragastric administration of cyclophosphamide 20mg / kg body weight every day, 2 times / d; combined treatment group: daily intragastric administration of zolpidem tartrate 0.5mg / kg+cyclophosphamide 10mg / kg body weight, 2 times / d. ...

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Abstract

The invention relates to cyclophosphamide containing pharmaceutical composition and application thereof in preparation of an anti-breast-cancer drug. The pharmaceutical composition can be in an oral preparation form such as a tablet, a capsule, a dry suspension, a drop pill or a granule and can also be in an injection preparation form such as an injection solution or a freeze-dried powder injection for injection. Cyclophosphamide and zolpidem tartrate are adopted as active components and have synergy and attenuation functions, sensitivity of cancer cells of a patient with estrogen receptor negative breast cancer to cyclophosphamide can be improved, and meanwhile, the toxic and side effects of the drug are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing cyclophosphamide and its application in the preparation of anti-breast cancer drugs. Background technique [0002] The female mammary gland is composed of skin, fibrous tissue, mammary glands and fat. Breast cancer is a malignant tumor that occurs in the mammary gland epithelial tissue. 99% of breast cancers occur in women and only 1% in men. The mammary gland is not an important organ to maintain human life activities, and breast cancer in situ is not fatal; but because breast cancer cells lose the characteristics of normal cells, the connections between cells are loose and easy to fall off. Once the cancer cells fall off, the free cancer cells can spread throughout the body with the blood or lymph fluid, forming metastasis, which is life-threatening. The global incidence of breast cancer has been on the rise since the lat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61P35/00A61K31/437
Inventor 张德芳刘伟
Owner 张德芳
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