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Metal oxide nanoparticle-based t1-t2 dual-mode magnetic resonance imaging contrast agent

A technology of T1-T2 and nanoparticles, which is applied in the fields of nuclear magnetic resonance/magnetic resonance imaging contrast agent, X-ray contrast agent preparation, manganese oxide/manganese hydroxide, etc., can solve the problem that the T1-T2 dual-mode MRI contrast agent has not been developed and other issues to achieve the effect of increasing image contrast enhancement

Active Publication Date: 2015-12-23
INTRON BIOTECHNOLOGY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

To date, no T1-T2 dual-mode MRI contrast agent suitable for clinical needs has been developed

Method used

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  • Metal oxide nanoparticle-based t1-t2 dual-mode magnetic resonance imaging contrast agent

Examples

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example 1

[0054] Example 1: Preparation of Manganese(II) Oxide Nanoparticles of Various Shapes

[0055] Preparation of octahedral manganese oxide nanoparticles

[0056] Octahedral manganese(II) oxide nanoparticles were synthesized by using a reported method (Chem. Mater. 18:1821, 2006) with some modifications. Briefly, manganese(II) formate (Mn(HCOO) 2 , 5mmol), oleic acid (13mmol) and trioctylamine (15mmol) were mixed in a 50ml round bottom flask. Under a strong flow of argon, the mixture was heated to 120° C. in an oil bath with magnetic stirring and kept at this temperature for 3 hours. The temperature was then increased to 330°C at a heating rate of 30°C per minute and the reaction was held at that temperature until a green color appeared. A green solid was obtained by cooling the reaction solution to room temperature, and washing with 1-propanol, followed by centrifugation (3 min, 3,500 rpm). The collected solid was washed again with ethanol several times and then dried ov...

example 2

[0063] Example 2: Preparation of iron oxide nanoparticles with a central MnO phase

[0064] Preparation of iron oxide nanoparticles with central MnO core using octahedral manganese oxide nanoparticles particles

[0065] 14.2 mg of octahedral MnO nanoparticles and 0.375 mmol of iron(III) acetylacetonate were added to a solution of oleic acid (0.05 mmol), oleylamine (1 mmol) and trioctylamine (2 ml) in a 100 ml Schlenk tube. The Schlenk tube was heated in an oil bath under argon at a heating rate of 10 °C / min to 210 °C under vigorous stirring and held at this temperature for 20 min. The reaction mixture was then heated at 310° C. for 30 min in a dry air environment (oxygen percentage 20%). The black solution was cooled to room temperature. After cooling to room temperature, with the addition of acetone and n-propanol, iron oxide nanoparticles with a central MnO phase core precipitated and were collected by centrifugation (3 min, 3,500 rpm). The obtained nanoparticles w...

example 3

[0071] Example 3: Preparation of pyrenyl polyethylene glycol (pyrenyl PEG)

[0072] By making heterofunctionalized polyethylene glycol (NH 2 -PEGCOOH, molecular weight: 5,000Da) combined with the n-hydroxysuccinimide (NHS) group of 1-pyrene butyric acid n-hydroxysuccinimide ester (Py-NHS, molecular weight: 385.41Da) to synthesize pyrene-based polymers. Ethylene glycol (pyrenyl PEG). In detail, 3 mmol of Py-NHS and 1 mmol of NH 2 -PEG-COOH was dissolved in 15 ml dimethylformamide, and then 200 μl triethylamine was added to the reaction mixture at room temperature. After reacting for 48 hours at room temperature under a nitrogen atmosphere, the resulting product was filtered and washed with excess ether. The precipitate was dried under vacuum and stored for later use.

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Abstract

The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly a metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent that can be used not only as a T1 MRI contrast agent but also as a T2 MRI contrast agent, and a method for producing the same. The metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent can provide more accurate and detailed information associated with disease than single MRI contrast agent by the beneficial contrast effects in both T1 imaging with high tissue resolution and T2 imaging with high feasibility on detection of a lesion.

Description

technical field [0001] The present invention relates to a magnetic resonance imaging (MRI) contrast agent, especially a T1-T2 dual-mode MRI contrast agent based on metal oxide nanoparticles, which can be used not only as a T1 MRI contrast agent but also as a T2 MRI contrast agent. Background technique [0002] Among the various molecular imaging techniques, magnetic resonance imaging (MRI) is one of the most powerful and non-invasive diagnostic tools because MRI provides images with excellent anatomical detail based on the interaction of protons with molecules surrounding the tissue. image. [0003] MRI contrast agents are a group of contrast agents used to improve the visibility of internal body structures by increasing the contrast between normal and abnormal tissue in an MRI. MRI contrast agents alter the T1 (longitudinal) and T2 (transverse) relaxation times of tissues and the body cavity in which they reside. Depending on image weighting, this can signal a rise or fal...

Claims

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Application Information

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IPC IPC(8): A61K49/06A61K49/04A61K47/02A61K9/16
CPCA61K49/1875C01G45/02C01P2002/72C01P2004/04C01P2004/38C01P2004/84C01P2004/90A61K49/186A61K49/06A61K39/395A61K47/30A61K49/1818B05D7/54
Inventor 李光烈金珉植金泽勋武玉潘
Owner INTRON BIOTECHNOLOGY INC
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