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Cellulose acetate/chitosan blood dialysis membrane and preparation method thereof

A technology of cellulose acetate and hemodialysis, which is applied in semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of poor compactness, reduced passing rate of small molecular substances, and troubles in use, and achieves high passing rate. , good biocompatibility and biofunctionality, providing the effect of biocompatibility

Inactive Publication Date: 2015-12-16
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cellulose acetate is a porous membrane material and one of the earliest materials used in hemodialysis membranes. It can meet the requirements for the permeability of urea and water, but its compactness is poor. When used under high pressure, it will be The diameter of the dialysis material guide membrane becomes smaller, and the passage rate of small molecular substances in the blood is reduced. Therefore, its use can also cause trouble

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A cellulose acetate / chitosan hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.4μm, the pore size is 3.5μm, and the wall thickness is 70μm;

[0021] The dialysis membrane is prepared from the following parts by mass: 33 parts of cellulose acetate, 12 parts of chitosan, 5 parts of phosphoric acid, 3 parts of polyvinyl alcohol, 12 parts of tetrahydrofuran and 8 parts of dimethylacetamide.

[0022] A preparation method of cellulose acetate / chitosan hemodialysis membrane, the preparation steps are as follows:

[0023] (1) Spinning solution preparation: Add cellulose acetate, chitosan, phosphoric acid and polyvinyl alcohol to the mixed solution of tetrahydrofuran and dimethylacetamide, heat and dissolve in a 37℃ water bath, and ultrasonically shake for 5 minutes to obtain spinning Solution

[0024] (2) Electrospinning: Electrospin the spinning solution to prepare cellulose acetate / chitosan hemodialysis membrane;

[0025] Am...

Embodiment 2

[0029] A cellulose acetate / chitosan hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.4μm, the pore size is 3.5μm, and the wall thickness is 70μm;

[0030] The dialysis membrane is prepared from the following parts by mass: 56 parts of cellulose acetate, 18 parts of chitosan, 10 parts of phosphoric acid, 10 parts of polyvinyl alcohol, 22 parts of tetrahydrofuran and 16 parts of dimethylacetamide.

[0031] A preparation method of cellulose acetate / chitosan hemodialysis membrane, the preparation steps are as follows:

[0032] (1) Spinning solution preparation: Add cellulose acetate, chitosan, phosphoric acid and polyvinyl alcohol to the mixed solution of tetrahydrofuran and dimethylacetamide, heat and dissolve in a 37℃ water bath, and ultrasonically shake for 5 minutes to obtain spinning Solution

[0033] (2) Electrospinning: Electrospin the spinning solution to prepare cellulose acetate / chitosan hemodialysis membrane;

[0034]...

Embodiment 3

[0037] A cellulose acetate / chitosan hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.4μm, the pore size is 3.5μm, and the wall thickness is 70μm;

[0038] The dialysis membrane is prepared from the following parts by mass: 40 parts of cellulose acetate, 13 parts of chitosan, 6 parts of phosphoric acid, 5 parts of polyvinyl alcohol, 15 parts of tetrahydrofuran and 10 parts of dimethylacetamide.

[0039] A preparation method of cellulose acetate / chitosan hemodialysis membrane, the preparation steps are as follows:

[0040] (1) Spinning solution preparation: Add cellulose acetate, chitosan, phosphoric acid and polyvinyl alcohol to the mixed solution of tetrahydrofuran and dimethylacetamide, heat and dissolve in a 37℃ water bath, and ultrasonically shake for 5 minutes to obtain spinning Solution

[0041] (2) Electrospinning: Electrospin the spinning solution to prepare cellulose acetate / chitosan hemodialysis membrane;

[0042] A...

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Abstract

The invention discloses a cellulose acetate / chitosan blood dialysis membrane and a preparation method thereof, and relates to the field of biomaterials. The cellulose acetate / chitosan blood dialysis membrane is a hollow fiber film with hollow fiber diameter of 0.4-4 microns, aperture sizes of 2.2-4.8 microns and wall thickness of 40-80 microns. The dialysis membrane is prepared from 33-56 parts by mass of cellulose acetate, 12-18 parts by mass of chitosan, 5-10 parts by mass of phosphoric acid, 3-10 parts by mass of polyvinyl alcohol, 12-22 parts by mass of tetrahydrofuran and 8-16 parts by mass of dimethyl acetamide. The preparation method comprises 1, spinning liquid preparation and 2, electrostatic spinning. The cellulose acetate / chitosan blood dialysis membrane has good biocompatibility and good biofunctionability, has a high macromolecular protein retention rate and a high urea and water passing rate, and is an ideal dialysis membrane material.

Description

Technical field [0001] The invention belongs to the field of biological materials, and particularly relates to a cellulose acetate / chitosan hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] The hemodialysis membrane uses the principle of a semi-permeable membrane, with the help of solute gradients, osmotic gradients and water pressure gradients on both sides of the membrane to eliminate toxins and excessive water retention in the body, while replenishing the substances needed in the body, and maintaining electrolytes and electrolytes. The purpose of acid-base balance. [0003] Therefore, hemodialysis membrane materials should have the following requirements: (1) Biocompatibility; (2) Biofunctionality, that is, good dialysis performance; (3) Minimal host reactions, including allergies and coagulation reactions ; (4) Spinnability. [0004] There are two types of existing hemodialysis membrane materials: one is a cellulose aceta...

Claims

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Application Information

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IPC IPC(8): B01D69/08B01D71/16B01D67/00
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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