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Injectable nano-composite hydrogel having pH sensitive property

A sensitive characteristic and nano-composite technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., to achieve the effect of great social and economic benefits

Inactive Publication Date: 2015-12-09
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the circulation of nanoparticles in the body also brings certain risks.

Method used

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  • Injectable nano-composite hydrogel having pH sensitive property
  • Injectable nano-composite hydrogel having pH sensitive property
  • Injectable nano-composite hydrogel having pH sensitive property

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prepare a certain solubility of camptothecin / dimethyl sulfoxide solution, the final concentration is 5mg / mL; dissolve a certain mass of pH-sensitive cyclodextrin derivatives in dichloromethane to form a cyclodextrin / dichloromethane solution, the concentration 5% (w / v); the above two solutions were mixed into an oil phase according to a certain volume, and the ratio was 1:1; ultrasonically pulverized in a sealed ice bath for 2 minutes, and then added a certain concentration and volume of polyvinyl alcohol / PBS (pH = 7.5) Solution, the concentration is 1% (w / v); the water-oil ratio is 10:1; the sealed ultrasonic cell is pulverized for 3 minutes to form a primary emulsion, and then a certain concentration and volume of polyvinyl alcohol / PBS (pH=7.5) solution is added to obtain Mixed emulsion with a concentration of 0.3% (w / v); the ratio of primary emulsion to mixed emulsion is 1:2, stirred for 10 hours under a magnetic stirrer at 1300r / min, and the organic solvent is fully e...

Embodiment 2

[0043] Prepare a certain solubility of camptothecin / dimethyl sulfoxide solution, the final concentration is 5mg / mL; dissolve a certain mass of pH-sensitive cyclodextrin derivatives in dichloromethane to form a cyclodextrin / dichloromethane solution, the concentration 10% (w / v); the above two solutions were mixed into an oil phase according to a certain volume, and the ratio was 1:1; ultrasonically pulverized in a sealed ice bath for 2 minutes, and then added a certain concentration and volume of polyvinyl alcohol / PBS (pH = 7.5) Solution, the concentration is 1% (w / v); the water-oil ratio is 10:1; the sealed ultrasonic cell is pulverized for 3 minutes to form a primary emulsion, and then a certain concentration and volume of polyvinyl alcohol / PBS (pH=7.5) solution is added to obtain Mixed emulsion with a concentration of 0.3% (w / v); the ratio of primary emulsion to mixed emulsion is 1:2, stirred for 10 hours under a magnetic stirrer at 1300r / min, and the organic solvent is fully ...

Embodiment 3

[0047] Prepare a certain solubility of camptothecin / dimethyl sulfoxide solution, the final concentration is 1mg / mL; dissolve a certain mass of pH-sensitive cyclodextrin derivatives in dichloromethane to form a cyclodextrin / dichloromethane solution, the concentration 10% (w / v); the above two solutions were mixed into an oil phase according to a certain volume, and the ratio was 1:1; ultrasonically pulverized in a sealed ice bath for 2 minutes, and then added a certain concentration and volume of polyvinyl alcohol / PBS (pH = 7.5) Solution, the concentration is 1% (w / v); the water-oil ratio is 10:1; the sealed ultrasonic cell is pulverized for 3 minutes to form a primary emulsion, and then a certain concentration and volume of polyvinyl alcohol / PBS (pH=7.5) solution is added to obtain Mixed emulsion with a concentration of 0.3% (w / v); the ratio of primary emulsion to mixed emulsion is 1:2, stirred for 10 hours under a magnetic stirrer at 1300r / min, and the organic solvent is fully ...

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PUM

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Abstract

The invention discloses a preparation method of injectable nano-composite hydrogel having a pH sensitive property, wherein the preparation method comprises the following steps: 1. preparing materials: preparing lyophilized graphene oxide, and having cyclodextrin having a pH sensitive property; 2. preparing a cyclodextrin nanoparticle emulsion which contains antineoplastic drugs and has a pH sensitive property; and 3. preparing a composite hydrogel drug carrier. The injectable nano-composite hydrogel having the pH sensitive property prepared by the invention is applicable to a composite drug carrier for disease treatment and for drug controlled release. The product disclosed by the invention is consistent with basic requirements of the drug carrier in performance and is capable of controlling drug release; and the product is huge in social and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the preparation of a drug-loaded injectable composite hydrogel. Background technique [0002] Hydrogels are polymer networks formed by physical or chemical crosslinking of individual polymer chains, capable of absorbing large amounts of water and insoluble in water. The aqueous environment of hydrogel is more conducive to protecting cells and easily inactivated drugs such as peptides, proteins, oligonucleotides and DNA, and is also conducive to the transportation of nutrients and cell secretion products. It is an excellent tissue engineering scaffold and drug carrier materials. Since hydrogel can maintain a fluid state under certain conditions and form a body-shaped material with a certain shape and strength under external physical or chemical stimuli, this intelligence can be used to prepare injectable scaffolds, and play its role in repairing complex-shaped d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/04A61K47/40A61K45/00A61P35/00
Inventor 胡小红王昕陈频陈尚能
Owner JINLING INST OF TECH
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